PGR and APEX2

Number of citations of the paper that reports this interaction (PMID 12650714)
8

Data Source:
HPRD (in vitro, two hybrid)

		PGR	APEX2
Gene Name		progesterone receptor	APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Mitochondrial Outer Membrane	Nucleus Nucleolus Mitochondrial Inner Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Receptor Binding Steroid Binding Protein Binding Zinc Ion Binding Enzyme Binding	DNA Binding DNA-(apurinic Or Apyrimidinic Site) Lyase Activity Zinc Ion Binding Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity
	Biological Process	Ovulation From Ovarian Follicle Epithelial Cell Maturation Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Cell-cell Signaling Gene Expression Negative Regulation Of Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial Cell Proliferation Progesterone Receptor Signaling Pathway Tertiary Branching Involved In Mammary Gland Duct Morphogenesis	DNA Catabolic Process, Endonucleolytic DNA Catabolic Process, Exonucleolytic Base-excision Repair DNA Recombination Cell Cycle
Pathways		Nuclear signaling by ERBB4 Generic Transcription Pathway Nuclear Receptor transcription pathway Signaling by ERBB4
Drugs		Etonogestrel Desogestrel Megestrol Levonorgestrel Dydrogesterone Progesterone Fluticasone Propionate Medroxyprogesterone Norethindrone Ethynodiol Diacetate Mifepristone Norgestimate Drospirenone Danazol Allylestrenol Methyltrienolone Tanaproget Norelgestromin
Diseases
GWAS
Protein-Protein Interactions		49 interactors: ANP32A APEX2 ARID1A BATF3 BCAS2 BRCA1 CCNA1 CCNA2 CDC25B CDK2 COPS5 CSNK2A1 CUEDC2 DAP3 DDX54 ESR1 FKBP5 HMGB1 HMGB2 JDP2 KAT2B KLF9 NCOA1 NCOA3 NR0B1 PIAS1 PIAS2 PIAS3 POU2F1 POU2F2 PRKDC PRMT2 RBM23 RBM39 RELA RNF4 SMARCD1 SMARCE1 SNW1 SORBS1 SRC TAF1B TDG TRIM24 UBE3A UBR5 XRCC5 XRCC6 ZBTB17	11 interactors: APP CALCOCO2 CCDC85B EFEMP2 HOOK2 NEDD4L NINL PCNA PGR TRAF2 TRIM37
Entrez ID		5241	27301
HPRD ID		07077	06442
Ensembl ID		ENSG00000082175
Uniprot IDs		P06401 Q8TDS3	B4DWI9 B7ZA71 E5KN95 Q9UBZ4
PDB IDs		1A28 1E3K 1SQN 1SR7 1ZUC 2C7A 2OVH 2OVM 2W8Y 3D90 3G8O 3HQ5 3KBA 3ZR7 3ZRA 3ZRB 4A2J 4APU
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Receptor Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Nitrogen Compound Metabolic Process RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Androgen Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Hormone Chromosome Organization Regulation Of Cellular Process Chromatin Modification Cellular Response To Stimulus Response To Stimulus Chromatin Organization Cellular Response To Hormone Stimulus Regulation Of Cell Cycle Response To Steroid Hormone Organelle Organization Cellular Response To Organic Substance Intracellular Estrogen Receptor Signaling Pathway	Protein Monoubiquitination Protein Autoubiquitination Positive Regulation Of Deoxyribonuclease Activity Regulation Of Transcription From RNA Polymerase II Promoter Leading Strand Elongation Synaptic Growth At Neuromuscular Junction Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Caveolin-mediated Endocytosis Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Collateral Sprouting In Absence Of Injury Histone H2A-K119 Monoubiquitination Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Ubiquitination Regulation Of Protein Binding Positive Regulation Of Peptidase Activity Cell Maturation Response To Stress Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Gene Expression Regulation Of Gene Expression Protein Modification By Small Protein Conjugation Regulation Of Nitrogen Compound Metabolic Process Progesterone Receptor Signaling Pathway Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Negative Regulation Of Centriole Replication Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Caveolin-mediated Endocytosis Transcription Initiation From RNA Polymerase II Promoter Protein Polyubiquitination Axon Choice Point Recognition Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Glial Cell Apoptotic Process Cellular Homeostasis Response To Organic Substance Intracellular Receptor Signaling Pathway Negative Regulation Of Protein Localization To Cell Surface Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Tight Junction Assembly Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Neuron Remodeling Positive Regulation Of Protein Homodimerization Activity Mammary Gland Branching Involved In Pregnancy DNA-templated Transcription, Initiation Negative Regulation Of Sodium Ion Transport Translesion Synthesis
Tagcloud ?		antiperoxidase automatic automatically bauds computerized cutting dab get haemathoxyline immunocytochemistry immunoquantification immunoscore isc obtaining pixel plot recurrences reproducible robustness scene segmentation semilogarithmic simplicity sum summarizes telemedicine telequantification thresholds videophones	applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast
Tagcloud (Difference) ?		antiperoxidase automatic automatically bauds computerized cutting dab get haemathoxyline immunocytochemistry immunoquantification immunoscore isc obtaining pixel plot recurrences reproducible robustness scene segmentation semilogarithmic simplicity sum summarizes telemedicine telequantification thresholds videophones	applications catalytic display efficiency electron enabling endoplasmic engineered enrichment evolution far labeling live localization microscopy micu1 permits peroxidase precludes promiscuous proteomics requiring resolve reticulum submitochondrial superior tag yeast
Tagcloud (Intersection) ?