PFDN5 and BRMS1

Number of citations of the paper that reports this interaction (PMID 16919237)
26

Data Source:
HPRD (in vivo, two hybrid)

		PFDN5	BRMS1
Gene Name		prefoldin subunit 5	breast cancer metastasis suppressor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Prefoldin Complex	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Unfolded Protein Binding	Histone Deacetylase Activity Protein Binding Histone Deacetylase Binding NF-kappaB Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Folding Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated 'de Novo' Posttranslational Protein Folding Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Apoptotic Process Histone Deacetylation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Deacetylation Positive Regulation Of Anoikis
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Chromatin modifying enzymes Chromatin organization HDACs deacetylate histones
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		13 interactors: BRMS1 CALCOCO2 GLRX3 IKBKG IKZF3 ITSN1 MYC PFDN6 PSME3 TP73 TRIM28 TUBA1B TUBA3C	36 interactors: APP ARID4A BRMS1L CEP70 DNAJB1 DNAJB6 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 ING1 KPNA5 LINC00152 LRIF1 NMI PFDN5 RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNX6 SPOP SUDS3 TAF1 UBE2D1
Entrez ID		5204	25855
HPRD ID		05359	05879
Ensembl ID		ENSG00000123349	ENSG00000174744
Uniprot IDs		Q99471	G5E9I4 Q9HCU9
PDB IDs			2XUS 4AUV
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding Regulation Of Apoptotic Process 'de Novo' Protein Folding Regulation Of Cell Death Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Neuron Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Gamma Radiation Regulation Of Neuron Death Protein Folding Cellular Response To UV Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Transcription, DNA-templated Cellular Protein Complex Assembly Cellular Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catalytic Activity RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Protein Modification Process Negative Regulation Of DNA Demethylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Fibroblast Apoptotic Process Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Mitotic DNA Damage Checkpoint Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Chromatin Organization Chromatin Modification Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Protein Deacetylation Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Chromosome Organization Negative Regulation Of Biosynthetic Process Histone Modification Negative Regulation Of Cellular Metabolic Process Organelle Organization Negative Regulation Of Gene Expression, Epigenetic Histone H4 Deacetylation Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Histone H3 Deacetylation Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Gene Expression Cellular Response To Heat Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromatin Remodeling Positive Regulation Of Macromolecule Biosynthetic Process Response To Heat Positive Regulation Of Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process ATP-dependent Chromatin Remodeling Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process
Tagcloud ?		auf1 autonomous becomes bidirectional cdc25c ddb1 deregulated deregulation grpr hspd1 hyperparathyroidism hyperplastic irreversible mandatory naca nodular oasl oligonucleotide parathyroid physiologic polb prdx2 repressed responds subtraction taldo1 tpd52 vil2 xrcc1	adh6 aflatoxin areca arecoline bard1 betel ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Difference) ?		auf1 autonomous becomes bidirectional cdc25c ddb1 deregulated deregulation grpr hspd1 hyperparathyroidism hyperplastic irreversible mandatory naca nodular oasl oligonucleotide parathyroid physiologic polb prdx2 repressed responds subtraction taldo1 tpd52 vil2 xrcc1	adh6 aflatoxin areca arecoline bard1 betel ccnd2 cdk2ap1 cdkn1a cdkn2b chewing exonic fermented fgfr4 flnc gas1 hras il12b il8 indels msh6 nbl1 nitrosamines northeast nut quid rassf1 tobacco toxogenomic
Tagcloud (Intersection) ?