PFDN5 and NEUROG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFDN5	NEUROG2
Description		prefoldin subunit 5	neurogenin 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex Intermediate Filament Cytoskeleton	Chromatin Nucleus
	Molecular Function	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Protein Folding Negative Regulation Of DNA-templated Transcription Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly RNA Polymerase III Assembly	Nervous System Development Sensory Organ Development Cell Differentiation Forebrain Development Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Meat-related diet ( 32066663) Neuroblastoma (pediatric) ( 32599975) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		113 interacting genes: ABI2 ANKRD55 ATOSB BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C22orf39 CALCOCO2 CCDC198 CEBPA CIMIP1 CSPP1 DMRT3 DOK4 DOK5 EEIG1 ELK3 ESPNL FAAP20 FAM110A FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SAXO4 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 SPMIP2 SPMIP4 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VEZF1 VGLL1 WDR25 WHR1 YPEL5 ZC2HC1C ZNF148	2 interacting genes: ASCL1 PFDN5
Entrez ID		5204	63973
HPRD ID		05359	06976
Ensembl ID		ENSG00000123349	ENSG00000178403
Uniprot IDs		Q99471	Q9H2A3
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Pattern Specification Process MRF Binding Regionalization Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Axonemal A Tubule Inner Sheath	Oligodendrocyte Cell Fate Commitment Regulation Of Timing Of Subpallium Neuron Differentiation Carotid Body Glomus Cell Differentiation Noradrenergic Neuron Fate Commitment Cellular Response To Magnetism Subpallium Neuron Fate Commitment Lung Neuroendocrine Cell Differentiation Neuroblast Fate Determination RNA Polymerase III Assembly RNA Polymerase I Assembly Response To Magnetism Musculoskeletal Movement, Spinal Reflex Action Adrenal Chromaffin Cell Differentiation Vestibular Nucleus Development RNA Polymerase II Core Complex Assembly Ventral Spinal Cord Interneuron Fate Commitment Regulation Of Timing Of Neuron Differentiation Spinal Cord Oligodendrocyte Cell Fate Specification Olfactory Pit Development Stomach Neuroendocrine Cell Differentiation Oligodendrocyte Cell Fate Specification Cerebral Cortex GABAergic Interneuron Differentiation Noradrenergic Neuron Development Spinal Cord Oligodendrocyte Cell Differentiation Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Glial Cell Fate Specification Prefoldin Complex Forebrain Neuron Fate Commitment Glial Cell Fate Commitment Sympathetic Ganglion Development Response To Folic Acid Spinal Cord Association Neuron Differentiation Peripheral Nervous System Neuron Development GABAergic Neuron Differentiation Musculoskeletal Movement Regulation Of Timing Of Cell Differentiation Regulation Of Development, Heterochronic Motor Neuron Migration Negative Regulation Of Amyloid Fibril Formation Enteroendocrine Cell Differentiation Ganglion Development Sympathetic Nervous System Development Regulation Of Amyloid Fibril Formation Reflex Neuroendocrine Cell Differentiation Generation Of Neurons Cerebral Cortex Neuron Differentiation Glandular Epithelial Cell Differentiation Lung Epithelial Cell Differentiation Oligodendrocyte Development
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