PFDN5 and SCNM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFDN5	SCNM1
Description		prefoldin subunit 5	sodium channel modifier 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding	Protein Binding Zinc Ion Binding Enzyme Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Protein Folding Negative Regulation Of DNA-templated Transcription Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly RNA Polymerase III Assembly	Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS
Interacting Genes		113 interacting genes: ABI2 ANKRD55 ATOSB BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C22orf39 CALCOCO2 CCDC198 CEBPA CIMIP1 CSPP1 DMRT3 DOK4 DOK5 EEIG1 ELK3 ESPNL FAAP20 FAM110A FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SAXO4 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 SPMIP2 SPMIP4 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VEZF1 VGLL1 WDR25 WHR1 YPEL5 ZC2HC1C ZNF148	179 interacting genes: ADAMTSL4 AKAP9 AVPI1 AXIN2 BACH2 BEND7 BLZF1 CALCOCO2 CARD10 CARD9 CBY2 CCDC136 CCDC28B CCDC33 CCDC74B CCDC85B CDR2 CDR2L CEP44 CEP70 CEP76 CHIC2 CIB3 COG6 CTDSP1 CYSRT1 CYTIP DRC4 DVL2 EZHIP FAM161A FAM228A FANCL FHL2 FHL5 FNDC11 FRS3 FSD2 GIGYF1 GOLGA2 GOLGA6L9 GPRASP3 HAP1 HMBOX1 HMG20A HOMER3 HOMEZ HOOK2 HSF2BP IKZF1 IKZF3 INCA1 IRAK1BP1 JAKMIP1 KANK2 KATNBL1 KIFC3 KLF15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT38 KRT39 KRT40 KRT75 KRTAP1-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP5-9 LCN2 LDOC1 LHX1 LHX3 LIMS1 LNX1 LNX2 LRP2BP LZTS1 LZTS2 MCM6 MDFI MEOX2 MID2 MIPOL1 MKRN3 MORN3 MRPL28 MSS51 MTUS2 MYLIP MYO1F NAB2 NAP1L2 NBPF19 NDUFB7 NFKBID NOTCH2NLA NUTM1 PBX4 PDE4DIP PDLIM7 PFDN5 PIBF1 PICK1 PIH1D1 PLSCR1 PNMA1 PNMA2 PPP1R16A PPP1R16B PRDM14 PRNP PRR5L PSTPIP1 RBAK RBM11 RBM48 RDM1 REL RHOH RINT1 RORB RPGRIP1 RPH3AL SMARCD1 SORBS3 SSX2IP STX11 STX19 SYCE1 TAX1BP1 TFIP11 TLE5 TNNI1 TP53BP2 TRAF1 TRAF2 TRIB3 TRIM10 TRIM23 TRIM27 TRIM37 TRIM42 TRIM54 TTC23L UBXN11 USH1G USHBP1 VIM VMAC VPS52 VWC2 ZBTB1 ZBTB14 ZDHHC17 ZGPAT ZIM2 ZMAT1 ZMYND12 ZNF135 ZNF19 ZNF20 ZNF202 ZNF438 ZNF511 ZNF526 ZNF547 ZNF552 ZNF641 ZNF688 ZNF76 ZNF774 ZNF829 ZRANB1
Entrez ID		5204	79005
HPRD ID		05359	12162
Ensembl ID		ENSG00000123349	ENSG00000163156
Uniprot IDs		Q99471	Q9BWG6
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7	7DVQ 8Y7E
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Pattern Specification Process MRF Binding Regionalization Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Axonemal A Tubule Inner Sheath	Protein Binding Keratin Filament Intermediate Filament Zinc Ion Binding Intermediate Filament Organization Structural Constituent Of Skin Epidermis Identical Protein Binding Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Microtubule Binding Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Supramolecular Fiber Organization Centrosome TORC1 Complex Assembly Structural Molecule Activity Regulation Of Transcription By RNA Polymerase II DNA Binding Cytoskeleton Organization Ubiquitin Protein Ligase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade
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