PFDN5 and MYOT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFDN5	MYOT
Description		prefoldin subunit 5	myotilin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex Intermediate Filament Cytoskeleton	Cytoplasm Cytoskeleton Plasma Membrane Actin Cytoskeleton Membrane Z Disc Axon Sarcolemma Neuronal Cell Body
	Molecular Function	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding	Actin Binding Protein Binding Axon Guidance Receptor Activity Structural Constituent Of Muscle Alpha-actinin Binding
	Biological Process	Regulation Of DNA-templated Transcription Protein Folding Negative Regulation Of DNA-templated Transcription Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly RNA Polymerase III Assembly	Muscle Contraction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Synapse Organization
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases			Myofibrillar myopathies (MFM), including: Desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Myotilinopathy (MFM3); Zaspopathy (MFM4); Filaminopathy (MFM5); Bag3opathy Limb-girdle muscular dystrophy (LGMD) Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS			Atrial fibrillation ( 30061737) Heart rate ( 23583979) Severe malaria ( 29381699) Severe malaria (adjusted for sickle cell variant rs334) ( 29381699)
Interacting Genes		113 interacting genes: ABI2 ANKRD55 ATOSB BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C22orf39 CALCOCO2 CCDC198 CEBPA CIMIP1 CSPP1 DMRT3 DOK4 DOK5 EEIG1 ELK3 ESPNL FAAP20 FAM110A FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SAXO4 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 SPMIP2 SPMIP4 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VEZF1 VGLL1 WDR25 WHR1 YPEL5 ZC2HC1C ZNF148	17 interacting genes: ACTN1 ACTN2 ACTN3 APP AXIN1 DOCK9 FLNA FLNC GPRASP2 LRP12 NME7 PDLIM3 PFDN5 ST7 TFG TRIM55 TRIM63
Entrez ID		5204	9499
HPRD ID		05359	04981
Ensembl ID		ENSG00000123349	ENSG00000120729
Uniprot IDs		Q99471	A0A0C4DFM5 B4DT68 Q9UBF9
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7	2KDG 2KKQ
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Pattern Specification Process MRF Binding Regionalization Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Axonemal A Tubule Inner Sheath	Z Disc Integrin Binding Cytoskeletal Protein Binding Pseudopodium Actin Cytoskeleton Organization Actin Filament Binding Actin Binding Actin Filament Actin Filament-based Process Muscle Cell Development Focal Adhesion Assembly Actin Cytoskeleton Cell-substrate Junction Assembly Transmembrane Transporter Binding Cell-substrate Junction Organization Skeletal Muscle Atrophy Structural Constituent Of Muscle Cell Development Cortical Actin Cytoskeleton Cellular Component Assembly Regulation Of Glycolytic Process Skeletal Muscle Adaptation Striated Muscle Atrophy Sarcomere Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Platelet Alpha Granule Lumen Muscle Atrophy Regulation Of Carbohydrate Catabolic Process Focal Adhesion G Protein-coupled Receptor Binding Regulation Of ATP Metabolic Process Titin Binding Regulation Of Purine Nucleotide Metabolic Process Supramolecular Fiber Organization Identical Protein Binding Regulation Of Amyloid Fibril Formation Cytosol Negative Regulation Of Glycolytic Process Protein Serine/threonine Kinase Binding Organelle Organization Negative Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Potassium Ion Transport Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Negative Regulation Of Wnt Signaling Pathway Sarcomere Organization Dendritic Shaft
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