PFDN5 and RSRC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PFDN5	RSRC2
Description		prefoldin subunit 5	arginine and serine rich coiled-coil 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Prefoldin Complex Protein-containing Complex Intermediate Filament Cytoskeleton
	Molecular Function	Amyloid-beta Binding Transcription Corepressor Activity Protein Binding Unfolded Protein Binding	RNA Binding Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Protein Folding Negative Regulation Of DNA-templated Transcription Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Amyloid Fibril Formation RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly RNA Polymerase III Assembly
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC
Drugs
Diseases
GWAS			Hip circumference adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		113 interacting genes: ABI2 ANKRD55 ATOSB BCAS2 BCL6 BHLHE40 BRMS1 C10orf55 C10orf62 C22orf39 CALCOCO2 CCDC198 CEBPA CIMIP1 CSPP1 DMRT3 DOK4 DOK5 EEIG1 ELK3 ESPNL FAAP20 FAM110A FAM221A FAM222B FAM90A1 GLRX3 GLYCTK GPANK1 GSTO2 GUCD1 HAPLN2 HHEX HOXB9 HOXC8 IKBKG IKZF3 IL16 INCA1 IRX2 IRX6 ITSN1 KCTD9 KDM1A KLHL38 KLHL42 LARP4 LNX1 MAP2K5 METTL21A MISP MRPL45 MYC MYOT MYOZ1 NEUROG2 NOXA1 NTAQ1 PATZ1 PAX9 PFDN6 PHF1 PHF24 PILRA PITX1 PITX2 POGZ PRKAB2 PRPF18 PRR35 PSMB4 PSMB8 PSME3 RIBC1 RIPPLY1 RSRC2 RUSC1 SAXO1 SAXO4 SCNM1 SDCBP SHISA6 SLAIN1 SMAP1 SMG9 SNAI1 SNRNP25 SNRPB SOHLH1 SPAG8 SPG21 SPMIP2 SPMIP4 SYCE1L SYT17 TAF6L TBX3 TCF19 TFG TLE5 TP73 TRAPPC6A TRIM28 TUBA1B TUBA3C VAX2 VEZF1 VGLL1 WDR25 WHR1 YPEL5 ZC2HC1C ZNF148	21 interacting genes: AKAP9 APP CMTM5 CTAG1A CTAG1B GOLGA2 KASH5 NAV1 OGT PFDN5 PNMA1 RINT1 SAMD4B SRPK1 SRPK2 TRIM23 TRIM54 UBQLN1 UBQLN2 UBQLN4 UPF2
Entrez ID		5204	65117
HPRD ID		05359	13342
Ensembl ID		ENSG00000123349	ENSG00000111011
Uniprot IDs		Q99471	Q7L4I2
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Protein Binding Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Sequence-specific Double-stranded DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process Pattern Specification Process MRF Binding Regionalization Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Axonemal A Tubule Inner Sheath	Cytoplasm Positive Regulation Of Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Response To Stress Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Autophagy Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Identical Protein Binding Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Amyloid Fibril Formation Positive Regulation Of ERAD Pathway Regulation Of Protein Metabolic Process Macromolecule Metabolic Process TRNA Threonylcarbamoyladenosine Metabolic Process Microtubule-based Process Autophagy Regulation Of ERAD Pathway Microtubule Nucleation Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Innate Immune Response Growth Cone Lamellipodium Protein-containing Complex Organization Regulation Of Response To Calcium Ion Amylin Binding Cellular Component Assembly Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Defense Response RNA Polymerase III Assembly RNA Polymerase I Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Store-operated Calcium Channel Activity Negative Regulation Of Cellular Component Organization Organelle Assembly Cis-Golgi Network Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication Regulation Of Macroautophagy Defense Response To Symbiont Regulation Of Glycolytic Process Defense Response To Other Organism Protein-containing Complex Nucleic Acid Metabolic Process Microtubule Cytoskeleton Organization Positive Regulation Of Protein Catabolic Process
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