BRMS1 and RBBP4

Number of citations of the paper that reports this interaction (PubMedID 15451426)
0

Data Source:
HPRD (in vivo)

		BRMS1	RBBP4
Description		BRMS1 transcriptional repressor and anoikis regulator	RB binding protein 4, chromatin remodeling factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Histone Deacetylase Complex Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Cytosol NuRD Complex NURF Complex Protein-containing Complex CAF-1 Complex ESC/E(Z) Complex Sin3-type Complex ATPase Complex
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding ATP-dependent Activity, Acting On DNA Nucleosomal DNA Binding Histone Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Brain Development Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation
Pathways		HDACs deacetylate histones Potential therapeutics for SARS	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 Polo-like kinase mediated events PRC2 methylates histones and DNA Oxidative Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Activation of anterior HOX genes in hindbrain development during early embryogenesis Deposition of new CENPA-containing nucleosomes at the centromere Regulation of TP53 Activity through Acetylation Cyclin E associated events during G1/S transition G1/S-Specific Transcription Cyclin A:Cdk2-associated events at S phase entry RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Potential therapeutics for SARS Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)
Interacting Genes		50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1	59 interacting genes: AEBP2 ANXA7 ARMC12 BRCA1 BRMS1 BRMS1L CDKN1A CHAF1B CREB1 CREBBP CYTOR DDB1 DHX30 ESR1 EXOSC8 FOXK2 H1-1 H2AC20 H3-4 H3C1 H3C14 H4C14 H4C16 HDAC1 HDAC2 HDAC3 HDAC4 HMOX2 ING1 KPNA5 LIN9 LMNA MBD2 MBD3 MTA1 MTA2 NR2E3 PRDM16 RB1 RBBP7 RBP1 RPN1 RPN2 RYBP SALL4 SAP30 SIN3A SMN1 SNCA SP1 SP3 SPEN STAT5B SUMO2 SUV39H1 TK1 TSSK3 USP7 XRCC6
Entrez ID		25855	5928
HPRD ID		05879	04232
Ensembl ID		ENSG00000174744	ENSG00000162521
Uniprot IDs		G5E9I4 Q9HCU9	Q09028
PDB IDs		2XUS 4AUV	2XU7 3GFC 4PBY 4PBZ 4PC0 4R7A 5FXY 5VTB 5WAI 5WAK 5XWR 5XXQ 5Y1U 6BW3 6BW4 6C23 6C24 6G16 6NQ3 6WKR 6ZRC 6ZRD 7AOA 7KSO 7KSR 7KTP 7M40 7N40 7R1D 7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 8EQV 8FYH 8IQF 8IQG 8T9G 8TAS 8TB9 8TX8 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex	Chromatin Remodeling Chromatin Organization Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Epigenetic Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Nucleus Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Heterochromatin Formation Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance DNA Binding Histone Deacetylase Complex NuRD Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Repressor Complex Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Rhythmic Process Chromatin Binding Positive Regulation Of Stem Cell Population Maintenance Regulation Of Macromolecule Metabolic Process Protein-containing Complex Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Fate Specification Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Developmental Process Chromatin Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Chromosome
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