BRMS1 and PSMC3IP

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		BRMS1	PSMC3IP
Description		BRMS1 transcriptional repressor and anoikis regulator	PSMC3 interacting protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Condensed Nuclear Chromosome Nucleus Nucleoplasm DNA Recombinase Auxiliary Factor Complex
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	DNA Binding Double-stranded DNA Binding Transcription Coactivator Activity Protein Binding Recombinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis	Meiotic Joint Molecule Formation DNA Recombination Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Meiotic Strand Invasion Involved In Reciprocal Meiotic Recombination Positive Regulation Of DNA-templated Transcription Meiotic Cell Cycle
Pathways		HDACs deacetylate histones Potential therapeutics for SARS	Meiotic recombination
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Colorectal or endometrial cancer ( 26621817) White blood cell count ( 32888494)
Interacting Genes		50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1	20 interacting genes: AR AURKA BCAR3 BRMS1 CASP8 CHEK2 ERBB2 ESR1 ESR2 FGFR4 FZR1 NOTCH2 NR3C1 PIK3CA PSMC3 RB1CC1 RXRA TGFB1 THRB XRCC3
Entrez ID		25855	29893
HPRD ID		05879	16362
Ensembl ID		ENSG00000174744	ENSG00000131470
Uniprot IDs		G5E9I4 Q9HCU9	A0A158RUX1 K7ERB6 Q9P2W1
PDB IDs		2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex	Nuclear Receptor Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Estrogen Response Element Binding Positive Regulation Of Metabolic Process Nuclear Receptor-mediated Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Nuclear Steroid Receptor Activity Hormone-mediated Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cell Death Programmed Cell Death Steroid Binding Regulation Of MiRNA Metabolic Process Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Response To Lipid Liver Development Intracellular Receptor Signaling Pathway Enzyme Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Population Proliferation Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of DNA-templated Transcription Positive Regulation Of MiRNA Transcription Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gland Development Myeloid Leukocyte Differentiation Positive Regulation Of Biosynthetic Process Positive Regulation Of MiRNA Metabolic Process Animal Organ Development Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Positive Regulation Of Protein Metabolic Process
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