BRMS1 and SNX6

Number of citations of the paper that reports this interaction (PubMedID 20830743)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		BRMS1	SNX6
Description		BRMS1 transcriptional repressor and anoikis regulator	sorting nexin 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Nucleus Cytoplasm Lysosome Endosome Early Endosome Cytosol Membrane Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Tubular Endosome Postsynaptic Early Endosome Glutamatergic Synapse
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	Protein Binding Lipid Binding Dynactin Binding Type I Transforming Growth Factor Beta Receptor Binding Phosphatidylinositol Binding Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis	Intracellular Protein Transport Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Transport Regulation Of Macroautophagy Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Retrograde Transport, Endosome To Golgi Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of DNA-templated Transcription Cellular Response To Epidermal Growth Factor Stimulus Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Regulation Of Histamine Secretion By Mast Cell Cellular Response To Amyloid-beta
Pathways		HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Atrial fibrillation ( 29892015) Celiac disease ( 23936387) Diastolic blood pressure ( 30224653) Normal facial asymmetry (angle of surface orientation score) ( 30631343)
Interacting Genes		50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1	29 interacting genes: ACVR2B ACVRL1 BMPR1B BRCA1 BRMS1 CALM1 COIL CSNK2A2 CUL3 DISC1 EGFR ESR1 INSR ITSN1 LEPR NDEL1 NRP1 OGT OPTN PDGFRA PIM1 SNX1 SNX2 SNX4 TEX11 TGFBR1 TGFBR2 TNIK TPT1
Entrez ID		25855	58533
HPRD ID		05879	12086
Ensembl ID		ENSG00000174744	ENSG00000129515
Uniprot IDs		G5E9I4 Q9HCU9	A0A0A0MRI2 Q9UNH7
PDB IDs		2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex	Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Cell Communication Regulation Of Signal Transduction Receptor Complex Regulation Of Signaling Regulation Of Developmental Process Protein Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Multicellular Organismal Process Activin Binding Kinase Activity Anatomical Structure Morphogenesis Regulation Of Intracellular Signal Transduction Retina Vasculature Development In Camera-type Eye Positive Regulation Of Developmental Process Positive Regulation Of Signal Transduction Developmental Process Positive Regulation Of Cell Population Proliferation Leptin Receptor Binding Cellular Response To Growth Factor Stimulus Positive Regulation Of Multicellular Organismal Process Animal Organ Development Cell Surface Receptor Signaling Pathway Signal Transduction Transforming Growth Factor Beta Receptor Activity, Type I Response To Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Activin Receptor Complex Activin Receptor Activity, Type I Animal Organ Morphogenesis Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Activity Protein Serine/threonine Kinase Activity Transferase Activity Multicellular Organism Development Protein-containing Complex Regulation Of Programmed Cell Death System Development Transferrin Receptor Binding Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation SMAD Binding Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Vasculature Development Identical Protein Binding
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