BRMS1 and MRC2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		BRMS1	MRC2
Description		BRMS1 transcriptional repressor and anoikis regulator	mannose receptor C-type 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Focal Adhesion Membrane
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	Protein Binding Collagen Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis	Osteoblast Differentiation Endocytosis Collagen Catabolic Process
Pathways		HDACs deacetylate histones Potential therapeutics for SARS	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)	Diastolic blood pressure ( 28135244 30578418) Heel bone mineral density ( 30598549) Pulse pressure ( 28135244 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1	14 interacting genes: AKT1 BAG4 BRMS1 ESR2 MTDH NDEL1 PALB2 PAX2 PPM1D PTPN1 RAF1 RB1CC1 SLC26A4-AS1 XRCC3
Entrez ID		25855	9902
HPRD ID		05879	10094
Ensembl ID		ENSG00000174744	ENSG00000011028
Uniprot IDs		G5E9I4 Q9HCU9	Q9UBG0
PDB IDs		2XUS 4AUV	5AO5 5AO6 5E4K 5E4L 5EW6
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex	Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibroblast Migration Inner Cell Mass Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Stem Cell Population Maintenance Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Negative Regulation Of Macromolecule Metabolic Process NF-kappaB Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Carbohydrate Homeostasis Apoptotic Process Negative Regulation Of Metabolic Process Glucose Homeostasis Regulation Of Fibroblast Migration Negative Regulation Of RNA Metabolic Process Response To Fluid Shear Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Programmed Cell Death Cell Death Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TRNA Methylation Response To Epidermal Growth Factor
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