BRMS1 and KLK9

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		BRMS1	KLK9
Description		BRMS1 transcriptional repressor and anoikis regulator	kallikrein related peptidase 9
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Sin3-type Complex	Extracellular Region Extracellular Space Secretory Granule
	Molecular Function	Protein Binding Histone Deacetylase Binding NF-kappaB Binding	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Protein Deacetylation Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Anoikis	Proteolysis Protein Maturation
Pathways		HDACs deacetylate histones Potential therapeutics for SARS
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756)
Interacting Genes		50 interacting genes: ANGPTL4 APP ARID4A BEX2 BRMS1L CEP70 CSNK2A1 CYTOR DIRAS3 DNAJB1 DNAJB6 E2F1 EEF1A1 EP300 GOLGB1 HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HSP90AA1 HSPA4 IL13RA2 ING1 KLK9 KPNA5 LRIF1 LYPD3 MCRS1 MRC2 NMI PFDN5 PSMC3IP RBBP4 RBBP7 RBP1 RELA SAP30 SIN3A SMARCE1 SMTN SNAI1 SNX6 SPOP SRC SUDS3 TAF1 THRSP UBE2D1	11 interacting genes: APP BAG4 BRMS1 CASP8 CCND1 CHEK2 ESR1 ESR2 PAX2 PTPRJ TGFB1
Entrez ID		25855	284366
HPRD ID		05879	05692
Ensembl ID		ENSG00000174744	ENSG00000213022
Uniprot IDs		G5E9I4 Q9HCU9	Q2XQG6 Q9UKQ9
PDB IDs		2XUS 4AUV
Enriched GO Terms of Interacting Partners?		Sin3-type Complex Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Histone Deacetylase Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Stem Cell Population Maintenance Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Histone Deacetylase Activity Regulation Of Primary Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Histone Deacetylase Binding Chromatin Remodeling Protein Lysine Deacetylase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Signal Transduction Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Locomotion Negative Regulation Of Developmental Process Nucleus Nucleoplasm Positive Regulation Of Developmental Process Negative Regulation Of Cell Migration Positive Regulation Of Multicellular Organismal Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Motility Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Metabolic Process Protein-containing Complex	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Estradiol Negative Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Activity Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Enzyme Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Response To Lipid Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Anoikis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Apoptotic Process Regulation Of Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Programmed Cell Death Regulation Of MiRNA Transcription Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Locomotion Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Locomotion Estrogen Response Element Binding Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Regulation Of Biological Quality Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branch Elongation Of An Epithelium Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Cycle Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Macrophage Differentiation
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