PFDN5 and TRIM28

Number of citations of the paper that reports this interaction (PMID 11585818)
21

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PFDN5	TRIM28
Gene Name		prefoldin subunit 5	tripartite motif containing 28
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Prefoldin Complex	Nucleus Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Unfolded Protein Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Binding Krueppel-associated Box Domain Binding Sequence-specific DNA Binding Poly(A) RNA Binding Chromo Shadow Domain Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Folding Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated 'de Novo' Posttranslational Protein Folding Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Epithelial To Mesenchymal Transition DNA Repair Transcription Initiation From RNA Polymerase II Promoter Embryo Implantation Gene Expression Protein Ubiquitination Protein Sumoylation Positive Regulation Of Transcription Factor Import Into Nucleus DNA Methylation Involved In Embryo Development Innate Immune Response Positive Regulation Of DNA Repair Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Oligomerization Convergent Extension Involved In Axis Elongation Embryonic Placenta Morphogenesis Negative Regulation Of DNA Demethylation Negative Regulation Of Viral Release From Host Cell Regulation Of Genetic Imprinting
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Generic Transcription Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: BRMS1 CALCOCO2 GLRX3 IKBKG IKZF3 ITSN1 MYC PFDN6 PSME3 TP73 TRIM28 TUBA1B TUBA3C	62 interactors: CBX1 CBX3 CBX5 CDC34 CDCA4 CEBPB CHAF1A CHD3 ESR1 FES HDAC10 HTRA2 IRF1 IRF7 LYN MAGEA2 MAGEA2B MAGEA3 MAGEA6 MAGED1 MYB NDNL2 NR3C1 NR4A1 NR4A3 PFDN5 PPP4C RNF4 SENP7 SERTAD1 SERTAD2 SETDB1 SIN3A SKI SMARCAD1 SPG7 STAT3 TRIM24 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2H UBE2I UBE2L3 UBE2N UBE2U VHL VIM YWHAQ ZNF10 ZNF133 ZNF140 ZNF197 ZNF354A ZNF382 ZNF420 ZNF496 ZNF689 ZNF74
Entrez ID		5204	10155
HPRD ID		05359	03445
Ensembl ID		ENSG00000123349	ENSG00000130726
Uniprot IDs		Q99471	Q13263
PDB IDs			1FP0 2RO1 2YVR
Enriched GO Terms of Interacting Partners?		'de Novo' Posttranslational Protein Folding Regulation Of Apoptotic Process 'de Novo' Protein Folding Regulation Of Cell Death Positive Regulation Of Response To DNA Damage Stimulus Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Response To DNA Damage Stimulus Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Protein Complex Assembly Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Neuron Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Response To Gamma Radiation Regulation Of Neuron Death Protein Folding Cellular Response To UV Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Transcription, DNA-templated Cellular Protein Complex Assembly Cellular Response To Stress DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Catalytic Activity RNA Biosynthetic Process Positive Regulation Of Metabolic Process Gene Expression Positive Regulation Of Protein Modification Process Negative Regulation Of DNA Demethylation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Fibroblast Apoptotic Process Signal Transduction In Response To DNA Damage Cellular Response To Light Stimulus Mitotic DNA Damage Checkpoint Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Protein K48-linked Ubiquitination RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Macromolecule Biosynthetic Process Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Protein Polyubiquitination Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Protein Catabolic Process Cellular Metabolic Process Regulation Of Cellular Process Cellular Protein Catabolic Process Positive Regulation Of Metabolic Process Protein Ubiquitination Biosynthetic Process Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Macromolecule Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process
Tagcloud ?		auf1 autonomous becomes bidirectional cdc25c ddb1 deregulated deregulation grpr hspd1 hyperparathyroidism hyperplastic irreversible mandatory naca nodular oasl oligonucleotide parathyroid physiologic polb prdx2 repressed responds subtraction taldo1 tpd52 vil2 xrcc1	accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Difference) ?		auf1 autonomous becomes bidirectional cdc25c ddb1 deregulated deregulation grpr hspd1 hyperparathyroidism hyperplastic irreversible mandatory naca nodular oasl oligonucleotide parathyroid physiologic polb prdx2 repressed responds subtraction taldo1 tpd52 vil2 xrcc1	accumulates aging becoming damaged depletion genomes il6 il8 ink4a insults kap1 knocked krab limits mediating mixture ois oncogene partially pathologies prevented profound reinforcing sasp secrete secretory senescence termed undergo
Tagcloud (Intersection) ?