PFDN1 and INPP5K

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PFDN1	INPP5K
Description		prefoldin subunit 1	inositol polyphosphate-5-phosphatase K
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex Protein-containing Complex	Ruffle Nucleus Cytoplasm Endoplasmic Reticulum Trans-Golgi Network Cytosol Plasma Membrane Membrane Ruffle Membrane Neuron Projection Perinuclear Region Of Cytoplasm
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Vasopressin Receptor Activity Protein Binding Inositol Bisphosphate Phosphatase Activity Hydrolase Activity Phosphatase Activity Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Trisphosphate Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Lipid Phosphatase Activity Inositol Trisphosphate Phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	In Utero Embryonic Development Regulation Of Glycogen Biosynthetic Process Lipid Metabolic Process Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of D-glucose Transmembrane Transport Actin Cytoskeleton Organization Response To Insulin Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Negative Regulation Of Dephosphorylation Positive Regulation Of Urine Volume Glucose Homeostasis Host-mediated Suppression Of Viral Transcription Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Glycerolipid Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Dephosphorylation Regulation Of Transport Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Calcium Ion Transport Cellular Response To CAMP Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Protein Targeting To Membrane Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Renal Water Transport
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)	Mean platelet volume ( 27863252)
Interacting Genes		55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	23 interacting genes: ANXA7 ARL6IP1 ATP5PF BDNF CDKN1A CPTP FADS6 FATE1 FBXO7 GOLT1B HMOX2 HSPB1 KRT31 NCOR2 PBX3 PFDN1 SFT2D2 SMN1 TANK TK1 TNFRSF10D TNKS TTR
Entrez ID		5201	51763
HPRD ID		05357	08489
Ensembl ID		ENSG00000113068	ENSG00000132376
Uniprot IDs		O60925	B7Z4V9 Q9BT40
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization
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