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INPP5K and TANK
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
INPP5K
TANK
Gene Name
inositol polyphosphate-5-phosphatase K
TRAF family member-associated NFKB activator
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytoplasm
Endoplasmic Reticulum
Trans-Golgi Network
Cytosol
Plasma Membrane
Membrane
Ruffle Membrane
Neuron Projection
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
Molecular Function
Inositol-polyphosphate 5-phosphatase Activity
Vasopressin Receptor Activity
Protein Binding
Inositol Bisphosphate Phosphatase Activity
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Phosphatidylinositol Trisphosphate Phosphatase Activity
Phosphatidylinositol Phosphate 5-phosphatase Activity
Lipid Phosphatase Activity
Inositol Trisphosphate Phosphatase Activity
Inositol-1,4,5-trisphosphate 5-phosphatase Activity
Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Biological Process
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Protein Kinase Activity
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Glucose Transport
Dephosphorylation
Actin Cytoskeleton Organization
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Negative Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Dephosphorylation
Positive Regulation Of Urine Volume
Glucose Homeostasis
Negative Regulation Of MAP Kinase Activity
Negative Regulation By Host Of Viral Transcription
Small Molecule Metabolic Process
Negative Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Insulin Receptor Signaling Pathway
Inositol Phosphate Dephosphorylation
Phosphatidylinositol Dephosphorylation
Negative Regulation Of Stress Fiber Assembly
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Calcium Ion Transport
Cellular Response To CAMP
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Protein Targeting To Plasma Membrane
Negative Regulation Of Protein Targeting To Membrane
Ruffle Assembly
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Renal Water Transport
Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Signal Transduction
I-kappaB Kinase/NF-kappaB Signaling
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Innate Immune Response
Pathways
Synthesis of PIPs at the plasma membrane
Metabolism of lipids and lipoproteins
Phospholipid metabolism
PI Metabolism
Activated TLR4 signalling
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
TRIF-mediated TLR3/TLR4 signaling
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
TRAF6 mediated IRF7 activation
MyD88-independent cascade
Innate Immune System
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS
Dietary macronutrient intake (
23372041
)
Educational attainment (
23722424
)
Obesity-related traits (
23251661
)
Presence of antiphospholipid antibodies (
23509613
)
Subcutaneous adipose tissue (
22589738
)
Treatment response for severe sepsis (
22310353
)
Protein-Protein Interactions
15 interactors:
ANXA7
ARL6IP1
BDNF
CDKN1A
CPTP
FATE1
HMOX2
KRT31
MAD2L1BP
NCOR2
PFDN1
SMN1
TANK
TK1
TTR
31 interactors:
AIMP2
APBA3
APP
ATP6V1H
BIK
CEP63
CHUK
COPB1
FBLN1
HLA-C
IKBKB
IKBKE
IKBKG
INPP5K
KPNA2
LAMC1
MAP4K5
MARCH5
PLK1
RACGAP1
SDC4
SMAD3
SRSF11
TBK1
TP53BP2
TRAF1
TRAF2
TRAF3
TRIM37
USP7
ZC3H12A
Entrez ID
51763
10010
HPRD ID
08489
04870
Ensembl ID
ENSG00000132376
ENSG00000136560
Uniprot IDs
B7Z4V9
F5GXZ0
Q9BT40
B2R7S3
Q6NW12
Q92844
PDB IDs
1KZZ
1L0A
Enriched GO Terms of Interacting Partners
?
Response To Organic Cyclic Compound
Response To Hyperoxia
Epithelium Development
Response To Abiotic Stimulus
Tube Development
Response To Anesthetic
Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter
Ceramide 1-phosphate Transport
Fetal Process Involved In Parturition
Response To Fluoxetine
Response To L-glutamate
Response To Metal Ion
Response To Light Stimulus
Response To Lipid
Skeletal Muscle Cell Proliferation
Response To Hormone
Taste Bud Development
Dendrite Extension
Heme Oxidation
Cellular Response To Norepinephrine Stimulus
Regulation Of Retinal Cell Programmed Cell Death
Response To Radiation
Tissue Development
Response To Extracellular Stimulus
Ceramide Transport
Response To Inorganic Substance
Response To Steroid Hormone
Anatomical Structure Development
Thyroid Hormone Transport
Intestinal Epithelial Cell Maturation
Axon Target Recognition
Digestive Tract Development
Response To Norepinephrine
Response To Ether
Response To Cortisol
Thymidine Metabolic Process
Epithelial Cell Differentiation
Digestive System Development
Response To Glucocorticoid
Mitotic Cell Cycle Checkpoint
Cellular Response To Growth Factor Stimulus
Response To Corticosteroid
Deoxyribonucleoside Monophosphate Biosynthetic Process
Negative Regulation Of Synaptic Transmission, GABAergic
Cellular Response To UV-B
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Heme Catabolic Process
Response To Growth Factor
Response To Toxic Substance
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Type I Interferon Production
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cytokine Production
Apoptotic Process
Viral Process
Regulation Of Innate Immune Response
Programmed Cell Death
Cell Death
Death
Cellular Response To Tumor Necrosis Factor
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Regulation Of Immune System Process
Innate Immune Response
Response To Tumor Necrosis Factor
Cellular Response To Stimulus
I-kappaB Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Immune Response
Positive Regulation Of Immune Response
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of NF-kappaB Transcription Factor Activity
Signaling
Immune Response-regulating Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Cell Communication
Signal Transduction
Regulation Of Cellular Process
Positive Regulation Of Signal Transduction
Regulation Of Cellular Protein Metabolic Process
Regulation Of Signal Transduction
Immune Response
Positive Regulation Of Type I Interferon Production
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Protein Phosphorylation
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of Cytokine Production
Positive Regulation Of Metabolic Process
Tagcloud
?
benzene
cargo
census
cleaning
conditional
crew
deck
gasoline
haematopoietic
haenszel
hodgkin
leukaemia
lymphatic
malignancies
mantel
nested
operations
ors
petroleum
record
referent
referents
register
registry
seamen
swedish
tankers
unloading
vapours
Tagcloud (Difference)
?
benzene
cargo
census
cleaning
conditional
crew
deck
gasoline
haematopoietic
haenszel
hodgkin
leukaemia
lymphatic
malignancies
mantel
nested
operations
ors
petroleum
record
referent
referents
register
registry
seamen
swedish
tankers
unloading
vapours
Tagcloud (Intersection)
?