PFDN1 and ZNF235

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		PFDN1	ZNF235
Description		prefoldin subunit 1	zinc finger protein 235
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex Protein-containing Complex	Nucleus
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	DNA Binding DNA-binding Transcription Factor Activity Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	Generic Transcription Pathway
Drugs
Diseases
GWAS		Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Reaction time ( 29844566)
Interacting Genes		55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	4 interacting genes: CDC37 FAM118B MRPL44 PFDN1
Entrez ID		5201	9310
HPRD ID		05357	05299
Ensembl ID		ENSG00000113068	ENSG00000159917
Uniprot IDs		O60925	Q14590
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization	Unfolded Protein Binding Protein Folding HSP90-CDC37 Chaperone Complex Ribonuclease III Activity Mitochondrial Translational Elongation Prefoldin Complex Negative Regulation Of Amyloid Fibril Formation Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Response To Type II Interferon Positive Regulation Of Type 2 Mitophagy Protein Kinase Regulator Activity Regulation Of Amyloid Fibril Formation Positive Regulation Of Mitophagy
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