PFDN1 and DEFA1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		PFDN1	DEFA1
Gene Name		prefoldin subunit 1	defensin, alpha 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Prefoldin Complex	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Azurophil Granule Lumen Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Unfolded Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Folding Cell Cycle Telencephalon Development Cerebellum Development Actin Cytoskeleton Organization B Cell Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding	Innate Immune Response In Mucosa Chemotaxis Immune Response Antibacterial Humoral Response Intracellular Estrogen Receptor Signaling Pathway Killing Of Cells Of Other Organism Innate Immune Response Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Alpha-defensins Defensins Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		54 interactors: ACTA1 ACTB ALB ASNA1 BRK1 CCDC85A CHGA DCTN1 DEFA1 DGCR14 EDRF1 EIF3C EIF4A2 EOMES EXT2 EZH2 FAM20C GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 KIAA1377 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 TUBA1A YEATS4 ZNF235	5 interactors: C1QB DEFA3 GSK3B PFDN1 SERPINF2
Entrez ID		5201	1667
HPRD ID		05357	00499
Ensembl ID		ENSG00000113068	ENSG00000206047
Uniprot IDs		O60925	P59665
PDB IDs			2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0
Enriched GO Terms of Interacting Partners?		Organelle Organization Cellular Localization Cellular Macromolecule Biosynthetic Process Cellular Component Assembly Macromolecule Biosynthetic Process Gene Expression Membrane Organization RNA Biosynthetic Process Cellular Protein Localization Establishment Of Protein Localization To Membrane Protein Localization Developmental Process Cerebral Cortex Regionalization Mitotic Cell Cycle Biosynthetic Process Cellular Process Cytoskeleton-dependent Intracellular Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Metabolic Process Establishment Of Localization In Cell Anatomical Structure Development RNA Metabolic Process Organelle Localization 'de Novo' Posttranslational Protein Folding Intracellular Transport Cell Cycle Process 'de Novo' Protein Folding Regulation Of Metabolic Process Telencephalon Regionalization Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Protein Localization To Organelle Positive Regulation Of Cellular Metabolic Process Protein Localization To Membrane Vesicle Localization Regulation Of Cilium Assembly Multicellular Organismal Development Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Phase Transition Anatomical Structure Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Killing Of Cells Of Other Organism Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Anatomical Structure Formation Involved In Morphogenesis	Defense Response Immune System Process Innate Immune Response Negative Regulation Of Type B Pancreatic Cell Development Superior Temporal Gyrus Development Re-entry Into Mitotic Cell Cycle Negative Regulation Of Neuron Maturation Hypermethylation Of CpG Island Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Regulation Of Blood Vessel Size By Renin-angiotensin Humoral Immune Response Cellular Response To Interleukin-3 Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Neuron Maturation Negative Regulation Of Glycogen (starch) Synthase Activity Telencephalon Development Immune Response Negative Regulation Of Plasminogen Activation Protein Localization To Microtubule Positive Regulation Of Cellular Component Biogenesis Negative Regulation Of Dendrite Morphogenesis Negative Regulation Of NFAT Protein Import Into Nucleus Negative Regulation Of Fibrinolysis Response To Stress ER Overload Response Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Cell Adhesion Regulation Of Fibrinolysis Positive Regulation Of Organelle Organization Positive Regulation Of Protein Export From Nucleus Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Dendrite Development Forebrain Development Innate Immune Response In Mucosa Intracellular Estrogen Receptor Signaling Pathway System Development Regulation Of DNA Methylation Positive Regulation Of Transforming Growth Factor Beta Production Myoblast Fusion Protein Localization To Cytoskeleton Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Killing Of Cells Of Other Organism Positive Regulation Of Collagen Biosynthetic Process Antibacterial Humoral Response Positive Regulation Of Collagen Metabolic Process Defense Response To Fungus
Tagcloud ?			a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized
Tagcloud (Difference) ?			a64 adenomas affects basic counteract defa4 deficiency doc downregulates egf egfr extraction hbd igfr immunostaining influencing oncological pleomorphic products promotes psoriasin qrt recombinant relevant s100a4 slightly transcript transformation visualized
Tagcloud (Intersection) ?