PFDN1 and ESS2

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		PFDN1	ESS2
Name		prefoldin subunit 1	ess-2 spliceosome associated protein
Structure
GO Annotations	Cellular Component	Cytoplasm Prefoldin Complex Protein-containing Complex	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Amyloid-beta Binding Protein Binding Protein Folding Chaperone Unfolded Protein Binding	Protein Binding
	Biological Process	Protein Folding Negative Regulation Of Amyloid Fibril Formation	MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC	None
GWAS		Alzheimer's disease ( 28183528 ) Alzheimer's disease in APOE e4- carriers ( 25778476 ) Bipolar disorder ( 31043756 ) Bipolar I disorder ( 31043756 ) Reaction time ( 29844566 )	No GWAS studies recorded
Interacting Genes		55 interacting genes: ACTA1 ACTB ALB BRK1 CCDC85A CEBPA CEP126 CHGA DCTN1 DEFA1 DMAP1 EDRF1 EIF3C EIF4A2 EOMES ESS2 EXT2 EZH2 FAM20C GET3 GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 YEATS4 ZNF235	33 interacting genes: ARMC7 CCDC57 CDK5RAP3 CEP55 CPSF7 CRP DGCR6 DHX16 EHMT2 EXOC8 EXOSC7 HOOK1 ITCH KRT31 LYST NEDD4 OGT OIP5 PFDN1 PRPF38B PRRC2B QARS1 RACK1 RBM22 RBM4 SMARCD1 THOC1 TRAK1 TTC14 UTP6 VIM WNK2 YAP1
Entrez ID		5201	8220
HPRD ID		05357	03452
Ensembl ID		ENSG00000113068	ENSG00000100056
Uniprot IDs		O60925	F8WEF8 Q96DF8
PDB IDs		6NR8 6NR9 6NRB 6NRC 6NRD 7WU7	8C6J 8RO2 9FMD
GO Terms Enriched among Interactors		Positive Regulation Of Microtubule Nucleation Structural Constituent Of Cytoskeleton Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Microtubule Nucleation Nuclear Matrix Positive Regulation Of DNA Recombination NuA4 Histone Acetyltransferase Complex Regulation Of Cell Cycle Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Microtubule Polymerization Positive Regulation Of Double-strand Break Repair Intracellular Protein Localization Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Glutamate Receptor Binding Regulation Of Cellular Component Organization	RNA Metabolic Process Cyclin Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing Lysosomal Transport Positive Regulation Of Stem Cell Population Maintenance Endosome To Lysosome Transport Vacuolar Transport Negative Regulation Of MAPK Cascade RNA Binding Regulation Of Stem Cell Population Maintenance Spliceosomal Complex Molecular Adaptor Activity Proline-rich Region Binding Regulation Of Macroautophagy Pre-mRNA Binding