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INPP5K and NCOR2
Number of citations of the paper that reports this interaction (PMID
11509665
)
27
Data Source:
BioGRID
(two hybrid)
INPP5K
NCOR2
Gene Name
inositol polyphosphate-5-phosphatase K
nuclear receptor corepressor 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Ruffle
Nucleus
Cytoplasm
Endoplasmic Reticulum
Trans-Golgi Network
Cytosol
Plasma Membrane
Membrane
Ruffle Membrane
Neuron Projection
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Membrane
Nuclear Matrix
Nuclear Body
Transcriptional Repressor Complex
Molecular Function
Inositol-polyphosphate 5-phosphatase Activity
Vasopressin Receptor Activity
Protein Binding
Inositol Bisphosphate Phosphatase Activity
Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Phosphatidylinositol Trisphosphate Phosphatase Activity
Phosphatidylinositol Phosphate 5-phosphatase Activity
Lipid Phosphatase Activity
Inositol Trisphosphate Phosphatase Activity
Inositol-1,4,5-trisphosphate 5-phosphatase Activity
Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
DNA Binding
Chromatin Binding
Transcription Corepressor Activity
Notch Binding
Protein Binding
Histone Deacetylase Binding
Protein N-terminus Binding
Biological Process
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Protein Kinase Activity
Phospholipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Glucose Transport
Dephosphorylation
Actin Cytoskeleton Organization
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Negative Regulation Of Peptidyl-serine Phosphorylation
Negative Regulation Of Dephosphorylation
Positive Regulation Of Urine Volume
Glucose Homeostasis
Negative Regulation Of MAP Kinase Activity
Negative Regulation By Host Of Viral Transcription
Small Molecule Metabolic Process
Negative Regulation Of Glycogen Biosynthetic Process
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Insulin Receptor Signaling Pathway
Inositol Phosphate Dephosphorylation
Phosphatidylinositol Dephosphorylation
Negative Regulation Of Stress Fiber Assembly
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Calcium Ion Transport
Cellular Response To CAMP
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Protein Targeting To Plasma Membrane
Negative Regulation Of Protein Targeting To Membrane
Ruffle Assembly
Negative Regulation Of Glycogen (starch) Synthase Activity
Positive Regulation Of Renal Water Transport
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Chromatin Organization
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Transforming Growth Factor Beta Receptor Signaling Pathway
Notch Signaling Pathway
Gene Expression
Cellular Lipid Metabolic Process
Small Molecule Metabolic Process
Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Synthesis of PIPs at the plasma membrane
Metabolism of lipids and lipoproteins
Phospholipid metabolism
PI Metabolism
Loss of Function of TGFBR2 in Cancer
Signaling by NOTCH1 HD Domain Mutants in Cancer
Metabolism of lipids and lipoproteins
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Generic Transcription Pathway
Signaling by NOTCH1
Transcriptional regulation of white adipocyte differentiation
Signaling by NOTCH1 in Cancer
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
FBXW7 Mutants and NOTCH1 in Cancer
TGFBR2 MSI Frameshift Mutants in Cancer
Fatty acid, triacylglycerol, and ketone body metabolism
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Chromatin organization
HDACs deacetylate histones
Loss of Function of SMAD2/3 in Cancer
Signaling by NOTCH
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
NOTCH1 Intracellular Domain Regulates Transcription
Chromatin modifying enzymes
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Constitutive Signaling by NOTCH1 PEST Domain Mutants
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs) (
23648065
)
Cognitive performance (
19734545
)
Protein-Protein Interactions
15 interactors:
ANXA7
ARL6IP1
BDNF
CDKN1A
CPTP
FATE1
HMOX2
KRT31
MAD2L1BP
NCOR2
PFDN1
SMN1
TANK
TK1
TTR
84 interactors:
AHR
AKT1
AP2M1
AR
ARNT
ATXN1
ATXN1L
BCL6
C1D
CBFA2T2
CEBPB
CEP63
CHUK
CIR1
CNOT2
DDX20
E2F1
ESR1
ESR2
FOS
FOXP1
HDAC1
HDAC10
HDAC3
HDAC4
HDAC5
HDAC7
HIST1H4A
HNF4A
INPP5K
IRF5
JUN
MYBL2
MYOD1
NCOA3
NCOA6
NCOR1
NFE2L2
NFKB1
NFKBIA
NFKBIB
NFKBIE
NR1D1
NR1H2
NR1H4
NR1I2
NR2F1
NR2F2
NR3C1
NR4A1
PML
POU2F1
PPARA
PPARD
PPARG
RANBP9
RARA
RARB
RARG
RBPJ
RELA
RUNX1
RUNX1T1
RXRA
RXRG
SAP30
SIN3A
SKIL
SNW1
SP1
SPEN
SRF
STAT5A
STAT5B
SUMO1
TBL1X
THRA
THRB
TNIK
TNIP2
UBE2I
VDR
YWHAE
ZBTB16
Entrez ID
51763
9612
HPRD ID
08489
02910
Ensembl ID
ENSG00000132376
ENSG00000196498
Uniprot IDs
B7Z4V9
F5GXZ0
Q9BT40
C9J0Q5
C9JE98
C9JFD3
Q9Y618
PDB IDs
1KKQ
1R2B
1XC5
2GPV
2L5G
2LTP
2ODD
3R29
3R2A
4A69
Enriched GO Terms of Interacting Partners
?
Response To Organic Cyclic Compound
Response To Hyperoxia
Epithelium Development
Response To Abiotic Stimulus
Tube Development
Response To Anesthetic
Regulation Of Cellular Ketone Metabolic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter
Ceramide 1-phosphate Transport
Fetal Process Involved In Parturition
Response To Fluoxetine
Response To L-glutamate
Response To Metal Ion
Response To Light Stimulus
Response To Lipid
Skeletal Muscle Cell Proliferation
Response To Hormone
Taste Bud Development
Dendrite Extension
Heme Oxidation
Cellular Response To Norepinephrine Stimulus
Regulation Of Retinal Cell Programmed Cell Death
Response To Radiation
Tissue Development
Response To Extracellular Stimulus
Ceramide Transport
Response To Inorganic Substance
Response To Steroid Hormone
Anatomical Structure Development
Thyroid Hormone Transport
Intestinal Epithelial Cell Maturation
Axon Target Recognition
Digestive Tract Development
Response To Norepinephrine
Response To Ether
Response To Cortisol
Thymidine Metabolic Process
Epithelial Cell Differentiation
Digestive System Development
Response To Glucocorticoid
Mitotic Cell Cycle Checkpoint
Cellular Response To Growth Factor Stimulus
Response To Corticosteroid
Deoxyribonucleoside Monophosphate Biosynthetic Process
Negative Regulation Of Synaptic Transmission, GABAergic
Cellular Response To UV-B
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Heme Catabolic Process
Response To Growth Factor
Response To Toxic Substance
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Transcription, DNA-templated
Transcription, DNA-templated
RNA Biosynthetic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Biosynthetic Process
Negative Regulation Of Nucleic Acid-templated Transcription
Regulation Of Transcription, DNA-templated
Negative Regulation Of RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of Gene Expression
Negative Regulation Of Biosynthetic Process
Gene Expression
Intracellular Receptor Signaling Pathway
RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Cellular Response To Organic Substance
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Response To Organic Substance
Hormone-mediated Signaling Pathway
Steroid Hormone Mediated Signaling Pathway
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
DNA-templated Transcription, Initiation
Biosynthetic Process
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Response To Lipid
Cellular Response To Hormone Stimulus
Cellular Response To Steroid Hormone Stimulus
Response To Lipid
Cellular Response To Organic Cyclic Compound
Anatomical Structure Development
Response To Hormone
System Development
Tagcloud
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
map2k5
maximise
mek5
men1
nbpf10
needle
ngs
opening
pik3cb
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Difference)
?
amico
atm
dissect
entered
erg
formalin
fusions
hiseq
illumina
map2k5
maximise
mek5
men1
nbpf10
needle
ngs
opening
pik3cb
qiagen
read
routinely
screen
sections
spop
technologies
templates
tmprrs2
unstained
yielded
Tagcloud (Intersection)
?