PFDN1 and PDHB

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		PFDN1	PDHB
Gene Name		prefoldin subunit 1	pyruvate dehydrogenase (lipoamide) beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Prefoldin Complex	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Pyruvate Dehydrogenase Complex Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Unfolded Protein Binding	Pyruvate Dehydrogenase Activity Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Protein Folding Cell Cycle Telencephalon Development Cerebellum Development Actin Cytoskeleton Organization B Cell Activation Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Protein folding Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Chaperonin-mediated protein folding	Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			Pyruvic acid NADH
Diseases
GWAS
Protein-Protein Interactions		54 interactors: ACTA1 ACTB ALB ASNA1 BRK1 CCDC85A CHGA DCTN1 DEFA1 DGCR14 EDRF1 EIF3C EIF4A2 EOMES EXT2 EZH2 FAM20C GIT1 GPRASP1 HAP1 HIP1 HMGXB3 HOXD8 IFT140 IMMT INPP5K JADE1 KIAA0408 KIAA1377 LRIF1 MED31 NDC80 NR2F1 PDE4DIP PDHB PFDN2 PLXNB2 PRKD2 PSME1 PTN RMI1 RPLP1 RPS28 SEC31A SKP2 SNX5 SPTBN4 SUMO3 SYNDIG1 TERT TTC38 TUBA1A YEATS4 ZNF235	15 interactors: ANXA7 CDKN1A DLAT FCER1A GNB2 GRB7 ITGB1 PDHA1 PDHA2 PDHX PFDN1 RAP1B RCC1 TRIM63 TSC22D1
Entrez ID		5201	5162
HPRD ID		05357	01530
Ensembl ID		ENSG00000113068	ENSG00000168291
Uniprot IDs		O60925	P11177
PDB IDs			1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI
Enriched GO Terms of Interacting Partners?		Organelle Organization Cellular Localization Cellular Macromolecule Biosynthetic Process Cellular Component Assembly Macromolecule Biosynthetic Process Gene Expression Membrane Organization RNA Biosynthetic Process Cellular Protein Localization Establishment Of Protein Localization To Membrane Protein Localization Developmental Process Cerebral Cortex Regionalization Mitotic Cell Cycle Biosynthetic Process Cellular Process Cytoskeleton-dependent Intracellular Transport Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Cellular Metabolic Process Establishment Of Localization In Cell Anatomical Structure Development RNA Metabolic Process Organelle Localization 'de Novo' Posttranslational Protein Folding Intracellular Transport Cell Cycle Process 'de Novo' Protein Folding Regulation Of Metabolic Process Telencephalon Regionalization Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Protein Localization To Organelle Positive Regulation Of Cellular Metabolic Process Protein Localization To Membrane Vesicle Localization Regulation Of Cilium Assembly Multicellular Organismal Development Regulation Of Cellular Process Regulation Of Mitotic Cell Cycle Phase Transition Anatomical Structure Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Killing Of Cells Of Other Organism Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Cell Cycle Phase Transition Anatomical Structure Formation Involved In Morphogenesis	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Pyruvate Metabolic Process Tricarboxylic Acid Cycle Citrate Metabolic Process Tricarboxylic Acid Metabolic Process Aerobic Respiration Regulation Of Cellular Ketone Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Monocarboxylic Acid Metabolic Process Regulation Of Fatty Acid Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Glucose Metabolic Process Generation Of Precursor Metabolites And Energy G1/S Transition Of Mitotic Cell Cycle Hemostasis Response To Organic Cyclic Compound Cellular Respiration Hexose Metabolic Process Carboxylic Acid Metabolic Process Regulation Of Body Fluid Levels Monosaccharide Metabolic Process Mitotic Cell Cycle Phase Transition Cellular Response To Ionizing Radiation Organic Acid Metabolic Process Regulation Of Cellular Process Cell Cycle Phase Transition Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Interleukin-3 Biosynthetic Process Positive Regulation Of Type I Hypersensitivity Regulation Of Vesicle-mediated Transport Positive Regulation Of Phosphorylation Glycolytic Process Cellular Response To Organic Cyclic Compound Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Regulation Of Collagen Catabolic Process Positive Regulation Of Protein Modification Process Small Molecule Metabolic Process Blood Coagulation Positive Regulation Of MAPK Cascade Response To Hormone Negative Regulation Of Synaptic Vesicle Exocytosis Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Calcium-independent Cell-matrix Adhesion Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Acetyl-CoA Biosynthetic Process From Pyruvate Positive Regulation Of Protein Kinase Activity Response To Organic Substance
Tagcloud ?			actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Difference) ?			actg1 alteration birc7 chrcc chromophobe cpq distinctions ectopic enabled exome faah2 fusions met mitf mutated nccrccs nf2 oncocytoma oncocytomas papillary pdxdc1 pnkd prcc rcc slc5a3 transcriptome trcc unreported znf765
Tagcloud (Intersection) ?