FARP2 and CDK4

Number of citations of the paper that reports this interaction (PubMedID 35525274)
44

Data Source:
BioGRID (pull down)

		FARP2	CDK4
Description		FERM, ARH/RhoGEF and pleckstrin domain protein 2	cyclin dependent kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol Bicellular Tight Junction Membrane Nuclear Membrane Cyclin D1-CDK4 Complex Cyclin D2-CDK4 Complex Cyclin D3-CDK4 Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Cytoskeletal Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Transferase Activity Cyclin Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Signal Transduction Neuron Remodeling Rac Protein Signal Transduction Hair Cycle Process Actin Cytoskeleton Organization Osteoclast Differentiation Regulation Of Integrin Activation Cell Development Semaphorin-plexin Signaling Pathway Podosome Assembly	G1/S Transition Of Mitotic Cell Cycle Signal Transduction Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Proliferation Cell Division Regulation Of Cell Cycle Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4 Cellular Response To Phorbol 13-acetate 12-myristate Cellular Response To Ionomycin
Pathways		SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion RAC1 GTPase cycle	SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Meiotic recombination Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity SPOP-mediated proteasomal degradation of PD-L1(CD274)
Drugs			Purvalanol Alvocidib Palbociclib Ribociclib Abemaciclib Fostamatinib Trilaciclib
Diseases			Malignant melanoma Glioma Cervical cancer
GWAS		Body size at age 10 ( 32376654) Cerebrospinal fluid immune biomarker levels ( 32066700) Chronic lymphocytic leukemia ( 23770605 28165464) Copper levels ( 26025379) Disability (impaired activities of daily living) ( 31707593) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422) Neutrophil percentage of granulocytes ( 27863252) Prostate cancer ( 23535732) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Triglyceride levels ( 32154731 32203549) Type 1 diabetes ( 34127860) Vitiligo ( 27723757)	Brain morphology (MOSTest) ( 32665545) Celiac disease or Rheumatoid arthritis ( 21383967) Rheumatoid arthritis ( 24390342 30423114)
Interacting Genes		9 interacting genes: BGLT3 CDH1 CDK4 CDK6 PDZK1 SRC UBC UBE2G2 YWHAG	136 interacting genes: AGAP2 AKT1 ANKRD12 ANXA7 APLP1 APP ARAF ARID4A ARNT ATP5F1B BAG6 BCL11A BECN1 BIRC5 BMPR1B BRCA1 CAMK1 CAPNS1 CCND1 CCND2 CCND3 CCNE1 CD44 CDC37 CDC45 CDC6 CDC7 CDKN1A CDKN1B CDKN1C CDKN2A CDKN2B CDKN2C CDKN2D CEBPA CIB1 CNOT7 CNTN2 DAZAP2 DDAH2 DUSP9 EIF4EBP2 EPHA2 ERBB2 FARP2 FBXO8 FGFR4 FOXM1 FZR1 GLIS2 GRM1 H1-0 H1-1 H1-3 HGF HIF1A HMGXB3 HOOK1 HSP90AB1 IFI27 IGF1R IKZF3 IL15RA INCA1 KDELR2 LATS2 LNX2 LUC7L2 MAP2K3 MAP2K5 MAP3K5 MAPK14 MAPRE2 MARCKS MCM2 MDM4 MET MYOD1 MZF1 NCOA2 NF2 NOL12 OGDHL ORC3 OTX2 PDGFRA PGD PIAS1 PKM POLD1 PPP2R1B PRKAR1A PSMD10 PTMA QARS1 RAF1 RASSF1 RB1 RBL1 RBL2 RFC1 RFC4 RPL34 SENP3 SERTAD1 SETDB1 SHOX2 SKP1 SLBP SMAD2 SMAD3 SNCA SPOP STK11 STUB1 TEAD2 TERT TGFBR1 TK1 TP53 TRMT2A TSC1 TSPYL2 UBE3A UBTF UHRF2 USP17L2 USP51 VTA1 WDR33 YBX3 ZBTB16 ZNF101 ZNF219 ZNF335 ZNF655
Entrez ID		9855	1019
HPRD ID		16885	00447
Ensembl ID		ENSG00000006607	ENSG00000135446
Uniprot IDs		O94887	P11802
PDB IDs			2W96 2W99 2W9F 2W9Z 3G33 5FWK 5FWL 5FWM 5FWP 6P8E 6P8F 6P8G 6P8H 7SJ3
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Localization Regulation Of Protein Localization Cyclin Binding Cyclin-dependent Protein Serine/threonine Kinase Activity Modification-dependent Protein Catabolic Process Regulation Of Cell Adhesion Regulation Of Intracellular Transport Negative Regulation Of Cell Adhesion Positive Regulation Of Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin D2-CDK6 Complex Post-translational Protein Modification Negative Regulation Of TORC1 Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of TORC1 Signaling TORC1 Signaling Cellular Response To Oxygen-containing Compound Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Fibroblast Proliferation Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex Cyclin D1-CDK6 Complex FBXO Family Protein Binding Negative Regulation Of TOR Signaling TOR Signaling Positive Regulation Of TOR Signaling Positive Regulation Of Protein Localization To Nucleus Regulation Of TORC1 Signaling Positive Regulation Of Protein Localization Regulation Of G2/M Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Cyclin D2-CDK4 Complex Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Proteasomal Protein Catabolic Process Protein Kinase C Inhibitor Activity Regulation Of Establishment Of Protein Localization Extracellular Exosome Regulation Of Cell-cell Adhesion Negative Regulation Of Multicellular Organismal Process Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Regulation Of Cell Cycle G2/M Phase Transition Protein Kinase Activity Regulation Of Cell-matrix Adhesion Epithelial Cell Development Positive Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Scavenger Receptor Binding Cellular Response To Progesterone Stimulus	Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of Cell Population Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Catalytic Activity Negative Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Kinase Activity Negative Regulation Of Apoptotic Process Intracellular Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of Phosphorylation Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Nucleoplasm Negative Regulation Of Cell Cycle Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Population Proliferation Regulation Of Cell Cycle Process Cellular Response To Stress Protein Kinase Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process
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