SCARB1 and APOA2

Number of citations of the paper that reports this interaction (PubMedID 10764676)
0

Data Source:
BioGRID (pull down)

		SCARB1	APOA2
Description		scavenger receptor class B member 1	apolipoprotein A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Plasma Membrane Caveola Cell Surface Membrane Endocytic Vesicle Membrane Extracellular Exosome	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Virus Receptor Activity Phosphatidylserine Binding Lipopolysaccharide Immune Receptor Activity Scavenger Receptor Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding High-density Lipoprotein Particle Receptor Activity	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Endothelial Cell Proliferation Cholesterol Catabolic Process Lipid Transport Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Nitric Oxide Mediated Signal Transduction Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Cholesterol Transport Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Vitamin Transmembrane Transport Wound Healing Vasodilation Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Regulation Of Phagocytosis High Density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cholesterol Import Intestinal Lipid Absorption Positive Regulation Of Sphingolipid Mediated Signaling Pathway	Negative Regulation Of Cytokine Production Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Lipid Transport Signal Transduction Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-8 Production Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways			PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs		Phosphatidyl serine	Zinc Copper Zinc acetate
Diseases			Familial amyloidosis
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 33020668 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Facial skin colour (CIELAB index b* value) ( 34648798) Gut microbiota relative abundance (Ruminococcus belonging to family Lachnospiraceae) ( 33208821) HDL cholesterol ( 20686565 30275531 24097068 25961943) HDL cholesterol levels ( 28334899 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 33339817 31217584 29403010) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) LDL cholesterol levels ( 32203549) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lipoprotein-associated phospholipase A2 activity and mass ( 20442857 23118302) Low density lipoprotein cholesterol levels ( 32154731) Lung function (FEV1) ( 30061609) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myocardial infarction ( 33532862) Renal cell carcinoma ( 21131975) Response to cyclophosphamide in systemic lupus erythematosus with lupus nephritis ( 26980576) Serum metabolite levels ( 33031748) Total bilirubin levels ( 29403010) Total cholesterol levels ( 33339817 29403010) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Vitamin E levels ( 21729881) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: APOA1 APOA2 APOE GPR35 KRTAP10-9 KRTAP5-9 LTB4R2 PDZK1 PEX5	31 interacting genes: ABCA13 APOC1 APOD APOF AQP6 C4A CATSPER1 CIAO2A CREB3 CYBC1 GET1 GJA8 HSD17B13 KIR2DL3 LMNA MUC1 NAXE NDRG1 PANX1 PDZK1IP1 PLTP PSCA SCARB1 SLC7A1 SSMEM1 STOM TAB1 TMEM45A TMEM82 TREM2 VKORC1
Entrez ID		949	336
HPRD ID		03024	00129
Ensembl ID		ENSG00000073060	ENSG00000158874
Uniprot IDs		A0A7P0Z4E3 B3KW46 B7ZKQ9 Q8WTV0	P02652
PDB IDs
Enriched GO Terms of Interacting Partners?		Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Assembly Chylomicron Phospholipid Efflux Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Protein-lipid Complex Assembly Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Positive Regulation Of Phospholipid Efflux Apolipoprotein Receptor Binding Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Lipoprotein Biosynthetic Process Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein-containing Complex Assembly Cellular Response To Amyloid-beta Regulation Of Intestinal Cholesterol Absorption Spherical High-density Lipoprotein Particle Lipoprotein Particle Binding Response To Amyloid-beta Regulation Of Cholesterol Transport Protein-containing Complex Organization Cholesterol Transport Regulation Of Intestinal Lipid Absorption Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Binding Regulation Of Cdc42 Protein Signal Transduction Sterol Transport Regulation Of Intestinal Absorption Phospholipid Transport Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Cholesterol Homeostasis Sterol Homeostasis Low-density Lipoprotein Particle Remodeling Endocytic Vesicle Lumen Negative Regulation Of Cholesterol Transport Cholesterol Metabolic Process	Regulation Of Cholesterol Transport Lipid Transport High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Regulation Of Lipid Transport High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Regulation Of Phosphatidylcholine Catabolic Process Lipid Transporter Activity Sterol Transport Respiratory Burst After Phagocytosis Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Regulation Of Phospholipid Catabolic Process Regulation Of Cholesterol Efflux Monoatomic Anion Channel Activity Positive Regulation Of Apoptotic Cell Clearance Respiratory Burst Involved In Defense Response Organophosphate Ester Transport Regulation Of Phosphatidylcholine Metabolic Process Regulation Of Apoptotic Cell Clearance Organic Hydroxy Compound Transport Cholesterol Transport Endoplasmic Reticulum Regulation Of Endocytosis Detection Of Molecule Of Bacterial Origin Phagocytosis, Recognition Kinase Activator Activity Regulation Of Lipid Metabolic Process Phosphatidylethanolamine Binding Regulation Of Transport Carbohydrate Derivative Transport Apolipoprotein Binding Ceramide Transport Positive Regulation Of Lipid Transport Membrane Phospholipid Transport Gap Junction Channel Activity Respiratory Burst Regulation Of Phagocytosis Gap Junction Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Efflux Cholesterol Metabolic Process Sterol Metabolic Process
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