SCARB1 and APOA2

Number of citations of the paper that reports this interaction (PMID 10764676)
4

Data Source:
BioGRID (pull down)

		SCARB1	APOA2
Gene Name		scavenger receptor class B, member 1	apolipoprotein A-II
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Caveola Cell Surface Endocytic Vesicle Membrane Microvillus Membrane Extracellular Vesicular Exosome	Extracellular Region Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Lipopolysaccharide Binding Phosphatidylserine Binding Lipopolysaccharide Receptor Activity Transporter Activity Protein Binding 1-phosphatidylinositol Binding High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Protein Homodimerization Activity High-density Lipoprotein Particle Receptor Activity	Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding
	Biological Process	Endothelial Cell Proliferation Androgen Biosynthetic Process Cholesterol Catabolic Process Receptor-mediated Endocytosis Cell Adhesion Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Cholesterol Storage Regulation Of Phosphatidylcholine Catabolic Process Phospholipid Transport Lipopolysaccharide Transport Viral Process Lipopolysaccharide-mediated Signaling Pathway Detection Of Lipopolysaccharide Cholesterol Efflux High-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Clearance High-density Lipoprotein Particle Clearance Wound Healing Lipoprotein Metabolic Process Cholesterol Homeostasis Blood Vessel Endothelial Cell Migration Recognition Of Apoptotic Cell Reverse Cholesterol Transport Small Molecule Metabolic Process Adhesion Of Symbiont To Host Regulation Of Phagocytosis Positive Regulation Of Nitric-oxide Synthase Activity Triglyceride Homeostasis Cholesterol Import	Retinoid Metabolic Process Acute Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Protein Folding Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Phototransduction, Visible Light Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Positive Regulation Of Cholesterol Esterification Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Viral Process Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Response To Glucocorticoid Negative Regulation Of Lipase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Cholesterol Transporter Activity
Pathways			Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport
Drugs		Phosphatidylserine
Diseases
GWAS		HDL cholesterol ( 20686565) Lipoprotein-associated phospholipase A2 activity and mass ( 23118302 20442857) Renal cell carcinoma ( 21131975) Vitamin E levels ( 21729881)
Protein-Protein Interactions		7 interactors: APOA1 APOA2 APOE KRTAP10-9 KRTAP5-9 PDZK1 PEX5	11 interactors: ABCA13 APOA1 APOA1BP APOC1 APOD APOF C4A CATSPER1 PLTP SCARB1 VKORC1
Entrez ID		949	336
HPRD ID		03024	00129
Ensembl ID		ENSG00000073060	ENSG00000158874
Uniprot IDs		B3KW46 B4DZ71 B4E3I1 B7ZKQ9 F8W8N0 Q8WTV0	P02652
PDB IDs			1L6L 2OU1
Enriched GO Terms of Interacting Partners?		High-density Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Esterification High-density Lipoprotein Particle Assembly Regulation Of Cholesterol Esterification Phospholipid Efflux High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Reverse Cholesterol Transport Plasma Lipoprotein Particle Remodeling Positive Regulation Of Steroid Metabolic Process Cholesterol Efflux Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Plasma Lipoprotein Particle Levels Cholesterol Transport Sterol Transport Cholesterol Homeostasis Sterol Homeostasis Phototransduction, Visible Light Retinoid Metabolic Process Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Diterpenoid Metabolic Process Detection Of Visible Light Regulation Of Lipid Transport Phospholipid Transport Negative Regulation Of Cytokine Secretion Involved In Immune Response Phototransduction Regulation Of Steroid Metabolic Process Organic Anion Transport Detection Of Light Stimulus Peptidyl-methionine Modification Peripheral Nervous System Axon Regeneration Triglyceride-rich Lipoprotein Particle Remodeling Cholesterol Metabolic Process Lipid Homeostasis Low-density Lipoprotein Particle Remodeling Isoprenoid Metabolic Process Negative Regulation Of Cholesterol Transport Sterol Metabolic Process Cellular Lipid Catabolic Process Regulation Of Cytokine Secretion Involved In Immune Response Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Negative Regulation Of Lipase Activity Anion Transport Negative Regulation Of Lipid Transport Phosphatidylcholine Biosynthetic Process Acylglycerol Catabolic Process	Cholesterol Efflux Lipid Transport Lipid Localization Sterol Transport Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Sterol Metabolic Process Plasma Lipoprotein Particle Clearance Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Lipid Catabolic Process High-density Lipoprotein Particle Clearance Regulation Of Plasma Lipoprotein Particle Levels Steroid Metabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Lipid Metabolic Process Lipid Metabolic Process Phospholipid Transport Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux Alcohol Metabolic Process Small Molecule Metabolic Process Protein-lipid Complex Assembly Endothelial Cell Proliferation Regulation Of Lipid Biosynthetic Process Reverse Cholesterol Transport Negative Regulation Of Lipase Activity Lipoprotein Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Endocytosis Blood Vessel Endothelial Cell Migration Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Wound Healing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Axon Regeneration Response To Wounding Neuron Projection Regeneration Regulation Of Inflammatory Response Sperm Motility Transport Positive Regulation Of Lipid Biosynthetic Process Regulation Of Phagocytosis Response To Axon Injury Negative Regulation Of Phosphatidylcholine Catabolic Process
Tagcloud ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt ppara pparg rasa sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Difference) ?		abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt ppara pparg rasa sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d	atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr
Tagcloud (Intersection) ?