SLC22A11 and CAV3

Number of citations of the paper that reports this interaction (PubMedID 18985008)
34

Data Source:
HPRD (in vitro)

		SLC22A11	CAV3
Description		solute carrier family 22 member 11	caveolin 3
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Caveola Focal Adhesion Cell Surface Intercalated Disc Dystrophin-associated Glycoprotein Complex Membrane Z Disc T-tubule Neuromuscular Junction Vesicle Protein-containing Complex Sarcolemma Membrane Raft
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Antiporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity	Calcium Channel Regulator Activity Protein Binding Sodium Channel Regulator Activity Potassium Channel Inhibitor Activity Enzyme Binding Alpha-tubulin Binding Transmembrane Transporter Binding Protein-containing Complex Binding Nitric-oxide Synthase Binding Molecular Adaptor Activity Connexin Binding
	Biological Process	Monoatomic Ion Transport Inorganic Anion Transport Organic Anion Transport Prostaglandin Transport Urate Metabolic Process Transmembrane Transport	MAPK Cascade Response To Hypoxia Plasma Membrane Repair Regulation Of Heart Rate Response To Ischemia Cardiac Muscle Hypertrophy Triglyceride Metabolic Process Calcium Ion Transport Endocytosis Plasma Membrane Organization Actin Filament Organization Positive Regulation Of Cytosolic Calcium Ion Concentration Muscle Organ Development Myoblast Fusion Regulation Of Heart Contraction Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Myotube Differentiation Regulation Of Skeletal Muscle Contraction Myotube Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Differentiation Positive Regulation Of Microtubule Polymerization Cytoplasmic Microtubule Organization Membrane Raft Organization T-tubule Organization Detection Of Muscle Stretch Regulation Of Signal Transduction By Receptor Internalization Regulation Of Membrane Potential Glucose Homeostasis Cholesterol Homeostasis Negative Regulation Of MAPK Cascade Negative Regulation Of Cell Size Regulation Of Nerve Growth Factor Receptor Activity Regulation Of Cytosolic Calcium Ion Concentration Nucleus Localization Establishment Of Localization In Cell Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transport Negative Regulation Of Calcium Ion Transport Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Negative Regulation Of Sarcomere Organization Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Heart Trabecula Formation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Caveola Assembly Protein Localization To Plasma Membrane Ventricular Cardiac Muscle Cell Action Potential Regulation Of Calcium Ion Import Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of P38MAPK Cascade Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Sodium Ion Transmembrane Transport Cellular Response To Ionomycin Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Caveolin-mediated Endocytosis
Pathways		Organic anion transport by SLC22 transporters	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs		Cefotaxime Probenecid Ceftriaxone Lesinurad
Diseases			Limb-girdle muscular dystrophy (LGMD) Caveolinopathies, including: Limb-girdle muscular dystrophy (LGMD) 1C; Rippling muscle disease (RMD); Idiopathic hyperCKemia; Distal myopathy with decreased caveolin 3; Hypertrophic cardiomyopathy (HCM) Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Body mass index ( 32363570) Gout ( 33832965 32238385) Gout vs asymptomatic hyperuricemia ( 33832965) Obesity-related traits ( 23251661) Renal underexcretion gout ( 32238385) Serum uric acid levels ( 26902266 30993211) Systemic lupus erythematosus ( 28714469) Urate levels ( 20884846 31578528 23263486) Urate levels in lean individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Caudate activity during reward ( 28927378) Takayasu arteritis ( 33308445)
Interacting Genes		3 interacting genes: CAV3 NHERF1 PDZK1	21 interacting genes: ADRB2 DAG1 DYSF EGFR GNAS INSR JPH2 KCNJ12 NOS1 PBX3 PCBP1 PDGFRA PDGFRB PFKM PTGES3 RBFA RYR1 SENP1 SLC22A11 SLC8A1 SNCA
Entrez ID		55867	859
HPRD ID		06161	03154
Ensembl ID		ENSG00000168065	ENSG00000182533
Uniprot IDs		Q9NSA0	P56539
PDB IDs		8WJH
Enriched GO Terms of Interacting Partners?		Protein Localization To Cell Periphery Protein Localization To Plasma Membrane Regulation Of Monoatomic Ion Transport Nucleus Localization Protein Localization To Membrane Microvillus Membrane Protein-membrane Adaptor Activity Localization Within Membrane Brush Border Membrane Regulation Of Sodium Ion Transport Regulation Of Cell Size PDZ Domain Binding Negative Regulation Of Monoatomic Ion Transport Plasma Membrane Organization Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of Sarcomere Organization Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Renal Phosphate Ion Absorption Negative Regulation Of MAPK Cascade Molecular Adaptor Activity Vesicle Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Caveolin-mediated Endocytosis Detection Of Muscle Stretch Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Localization Regulation Of Metal Ion Transport Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cellular Component Size Intracellular Protein Localization Regulation Of Transport Regulation Of Membrane Depolarization During Action Potential T-tubule Organization Cellular Response To Ionomycin Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity	Regulation Of System Process Sarcolemma T-tubule Muscle System Process Regulation Of Monoatomic Ion Transport Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Transport Regulation Of Muscle Contraction Muscle Contraction Receptor Complex Regulation Of Metal Ion Transport System Process Negative Regulation Of Serotonin Uptake Phospholipase C Activator Activity Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Regulation Of Calcium Ion Transport Regulation Of Serotonin Uptake Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Vascular Endothelial Growth Factor Binding Homeostatic Process Regulation Of Muscle System Process Sarcoplasmic Reticulum Membrane Positive Regulation Of The Force Of Heart Contraction Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Regulation Of Sequestering Of Calcium Ion Plasma Membrane Z Disc Glomerular Capillary Formation Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Response To Growth Factor Positive Regulation Of Transport Regulation Of Cellular Component Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chemical Homeostasis Calcium-mediated Signaling Cellular Response To Oxygen-containing Compound Junctional Sarcoplasmic Reticulum Membrane Cellular Response To Caffeine Apical Plasma Membrane Positive Regulation Of Monoatomic Ion Transport Regulation Of Biological Quality Sarcoplasmic Reticulum Platelet-derived Growth Factor Binding Regulation Of Heart Contraction
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