CRHR1

Description		corticotropin releasing hormone receptor 1
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GO Annotations	Cellular Component	Endosome Plasma Membrane Membrane Neuron Projection Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Corticotrophin-releasing Factor Receptor Activity Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding
	Biological Process	Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Female Pregnancy Parturition Hormone-mediated Signaling Pathway Adrenal Gland Development Cellular Response To Hormone Stimulus Exploration Behavior Fear Response Behavioral Response To Ethanol Regulation Of Transport Corticotropin Secretion General Adaptation Syndrome, Behavioral Process Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Corticosterone Secretion
Pathways		Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs		Corticorelin ovine triflutate
Diseases
GWAS		A body shape index ( 34021172) Accelerometer-based physical activity measurement (average acceleration) ( 29899525) Alcohol consumption (drinks per week) ( 30679032) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Brain morphology (MOSTest) ( 32665545) Cerebral white matter volume ( 31530798) Cortical surface area (global PC1) ( 32198502) Daytime nap ( 33568662) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General factor of neuroticism ( 30867560) Granulocyte count ( 27863252) Head circumference (infant) ( 22504419) Headache ( 29397368) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hip circumference adjusted for BMI ( 34021172) Household income (MTAG) ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Intake of total sugars ( 31005972) Intracranial volume ( 22504418) Joint mobility (Beighton score) ( 27182965) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Lymphocyte count ( 32888494) Male-pattern baldness ( 28196072) Maximum habitual alcohol consumption ( 31151762) Medication use (antithrombotic agents) ( 31015401) Monobrow ( 27182965) Mood instability ( 31168069) Multiple system atrophy ( 27629089) Myeloid white cell count ( 27863252) Neuroticism ( 29255261) Neutrophil count ( 27863252) Parkinson's disease ( 31660654 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cirrhosis ( 22961000) Reticulocyte count ( 32888494) Schizophrenia ( 33169155) Subcortical brain region volumes ( 25607358) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: ORMDL3
Interacting Genes		20 interacting genes: ARRB1 ARRB2 CALM1 CRH DLG1 DLG4 GNAI1 GNAO1 GNAQ GNAS GOPC MAGI1 MAGI2 MAGI3 MPDZ PDZK1 PTPN13 SRPK1 UCN UCN3
Entrez ID		1394
HPRD ID		08830
Ensembl ID		ENSG00000120088
Uniprot IDs		B3SXS2 B3TIK8 G3CIS4 K9J956 P34998
PDB IDs		2L27 3EHS 3EHT 3EHU 4K5Y 4Z9G 6P9X 6PB0 8GTG 8GTI 8GTM
Enriched GO Terms of Interacting Partners?		Corticotropin-releasing Hormone Receptor 1 Binding Regulation Of System Process Regulation Of Transport Regulation Of Muscle System Process Guanyl Nucleotide Binding Corticotropin-releasing Hormone Receptor 2 Binding Adenylate Cyclase Regulator Activity G-protein Beta/gamma-subunit Complex Binding Plasma Membrane G Protein-coupled Receptor Binding D1 Dopamine Receptor Binding Heterotrimeric G-protein Complex Varicosity Regulation Of Peptide Hormone Secretion Bicellular Tight Junction Negative Regulation Of Transport Regulation Of Protein Localization Regulation Of Hormone Secretion Signal Transduction Angiotensin Receptor Binding Negative Regulation Of Hormone Secretion Mu-type Opioid Receptor Binding G Protein Activity Regulation Of Insulin Secretion Regulation Of Muscle Contraction Regulation Of Receptor Internalization G Protein-coupled Serotonin Receptor Signaling Pathway Positive Regulation Of Transport Beta-1 Adrenergic Receptor Binding G Protein-coupled Serotonin Receptor Binding Regulation Of Cell Communication Regulation Of Signaling Response To Prostaglandin E Positive Regulation Of Receptor Internalization Response To Ketone Regulation Of Multicellular Organismal Process Regulation Of Striated Muscle Contraction Ionotropic Glutamate Receptor Binding Cell Projection Regulation Of Monoatomic Ion Transport Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization Postsynaptic Density Response To Alcohol Regulation Of Receptor-mediated Endocytosis Adenylate Cyclase Activator Activity Regulation Of Protein Secretion Dendrite Desensitization Of G Protein-coupled Receptor Signaling Pathway Modulation Of Chemical Synaptic Transmission
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