CRHR1 and UCN

Number of citations of the paper that reports this interaction (PMID 8612563)
27

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		CRHR1	UCN
Gene Name		corticotropin releasing hormone receptor 1	urocortin
Image
Gene Ontology Annotations	Cellular Component	Multivesicular Body Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Dendrite Intrinsic Component Of Plasma Membrane Vesicle Neuronal Cell Body Apical Part Of Cell	Extracellular Region Dendrite Varicosity Perikaryon Axon Terminus
	Molecular Function	G-protein Alpha-subunit Binding Protein Binding Corticotrophin-releasing Factor Receptor Activity Protein Complex Binding Corticotropin-releasing Hormone Receptor Activity Corticotropin-releasing Hormone Binding	Neuropeptide Hormone Activity Protein Binding Histone Deacetylase Inhibitor Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Response To Hypoxia Immune Response Activation Of Adenylate Cyclase Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Female Pregnancy Parturition Memory Visual Learning Hormone-mediated Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Hypothalamus Development Adrenal Gland Development Epithelial Cell Differentiation Negative Regulation Of Epinephrine Secretion Locomotory Exploration Behavior Response To Immobilization Stress Fear Response Positive Regulation Of Mast Cell Degranulation Behavioral Response To Cocaine Behavioral Response To Ethanol Behavioral Response To Pain Corticotropin Secretion Response To Electrical Stimulus General Adaptation Syndrome, Behavioral Process Long-term Synaptic Potentiation Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Neuron Death Negative Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Feeding Behavior Regulation Of Corticosterone Secretion	Inflammatory Response Response To Oxidative Stress G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Sensory Perception Of Sound Associative Learning Aerobic Respiration Negative Regulation Of Gene Expression Pancreatic Juice Secretion Positive Regulation Of Cell Growth Positive Regulation Of CAMP Biosynthetic Process Negative Regulation Of Histone Deacetylation Neuron Projection Development Negative Regulation Of Appetite Response To Estradiol Positive Regulation Of Interleukin-6 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Activation Of Protein Kinase A Activity Social Behavior Gastric Emptying Drinking Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Positive Regulation Of Translation Positive Regulation Of DNA Replication Negative Regulation Of Blood Pressure Negative Regulation Of Cell Size Positive Regulation Of Vasodilation Negative Regulation Of Hormone Secretion Response To Pain Response To Glucocorticoid Positive Regulation Of Corticotropin Secretion Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of Gastric Acid Secretion Negative Regulation Of Necrotic Cell Death Positive Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Negative Regulation Of Feeding Behavior Positive Regulation Of Behavioral Fear Response
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Head circumference (infant) ( 22504419) Intracranial volume ( 22504418)	Crohn's disease ( 23128233)
Protein-Protein Interactions		9 interactors: CALM1 CRH GNAI1 GNAO1 GNAQ GNAS SRPK1 UCN UCN3	4 interactors: CRHBP CRHR1 CRHR2 LEP
Entrez ID		1394	7349
HPRD ID		08830	02970
Ensembl ID		ENSG00000120088
Uniprot IDs		B3TIK8 G3CIS4 P34998	P55089
PDB IDs		2L27 3EHS 3EHT 3EHU 4K5Y	2RMF 3N96
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Biosynthetic Process Response To Stress Regulation Of CAMP Metabolic Process Response To Corticosterone Dopamine Receptor Signaling Pathway Response To Organic Cyclic Compound Response To Glucocorticoid Response To Corticosteroid Response To Mineralocorticoid Response To Hormone Regulation Of Calcium Ion Transport Platelet Activation Regulation Of Cellular Localization Positive Regulation Of Corticotropin Secretion Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Regulation Of Body Fluid Levels Regulation Of Corticotropin Secretion Signal Transduction Regulation Of Hormone Secretion Signaling Positive Regulation Of Ion Transmembrane Transport Positive Regulation Of Behavioral Fear Response Positive Regulation Of Peptide Hormone Secretion Cell Communication Positive Regulation Of Peptide Secretion Response To Organic Substance Positive Regulation Of Calcium Ion Transport Response To Organonitrogen Compound Response To Lipid Positive Regulation Of Hormone Secretion Negative Regulation Of Transport Cellular Response To Stimulus Blood Coagulation Positive Regulation Of Calcium Ion Import Hemostasis Response To Steroid Hormone Cell Surface Receptor Signaling Pathway Regulation Of Heart Contraction Regulation Of Calcium Ion Import Response To Immobilization Stress Behavior Wound Healing Activation Of Adenylate Cyclase Activity	Cellular Response To Corticotropin-releasing Hormone Stimulus Negative Regulation Of Hormone Secretion Response To Peptide Hormone Response To Peptide Cellular Response To Hormone Stimulus Negative Regulation Of Secretion By Cell Adult Behavior Behavioral Response To Ethanol Response To Organonitrogen Compound Negative Regulation Of Secretion Response To Hormone Female Pregnancy Regulation Of Hormone Secretion Regulation Of Hormone Levels Negative Regulation Of Signaling Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Negative Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Cocaine Single-organism Behavior Cellular Response To Organonitrogen Compound Secretion By Cell Cellular Response To Organic Substance Peptide Hormone Secretion Peptide Secretion Behavior Regulation Of Ion Transport Secretion Hormone Secretion Regulation Of Secretion Hormone Transport Response To Ammonium Ion Regulation Of Lipid Transport Peptide Transport Negative Regulation Of Ion Transport Response To Organic Substance Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Corticotropin Secretion Cellular Response To L-ascorbic Acid Negative Regulation Of Corticotropin-releasing Hormone Receptor Activity Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport General Adaptation Syndrome, Behavioral Process Amide Transport Hormone-mediated Signaling Pathway Response To Organic Cyclic Compound Response To Ethanol Regulation Of Ion Transmembrane Transporter Activity Cell-cell Signaling
Tagcloud ?		allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 urocortins vasodilation
Tagcloud (Difference) ?		allele alleles applicable asthmatics choice discriminate discriminating entered epidemiological era extensively feasible genotyping indian mutagenic north optimized perform pivotal primer primers restriction rflp rs1876828 snp throughput today undertook variant	agonists belonging cardioprotection cardiovascular congestive corticotropin crh exert gastrointestinal gpcr hormones inotropic lusitropic nervous r1 r2 releasing renin reperfusion reproductive restoration summarizes suppress sympathetic ucn1 ucn2 ucn3 urocortins vasodilation
Tagcloud (Intersection) ?