CLCN3 and PDZK1

Number of citations of the paper that reports this interaction (PMID 12471024)
25

Data Source:
HPRD (in vivo, in vitro)

		CLCN3	PDZK1
Gene Name		chloride channel, voltage-sensitive 3	PDZ domain containing 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Vesicle Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Specific Granule Phagocytic Vesicle	Cytoplasm Plasma Membrane Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity PDZ Domain Binding Protein Homodimerization Activity Protein Heterodimerization Activity Volume-sensitive Chloride Channel Activity	Scavenger Receptor Binding Transporter Activity Protein Binding PDZ Domain Binding Protein Complex Binding
	Biological Process	Transport Regulation Of PH Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Negative Regulation Of Cell Volume Endosomal Lumen Acidification Transmembrane Transport Chloride Transmembrane Transport	Transport Cell Proliferation Carnitine Transport Drug Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane
Pathways		Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS			Urate levels ( 20884846 23263486) Uric acid levels ( 19503597)
Protein-Protein Interactions		4 interactors: CFTR GOPC PDZK1 SLC9A3R1	27 interactors: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 FARP2 GFAP PDZK1IP1 PEX5 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A3 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I
Entrez ID		1182	5174
HPRD ID		02785	04829
Ensembl ID		ENSG00000109572	ENSG00000174827
Uniprot IDs		B3KXK0 B9EGJ9 P51790	Q5T2W1
PDB IDs			2EEI 2EEJ 2VSP 3TMH
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Transmembrane Transport Organic Anion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Anion Transport Cytoplasmic Sequestering Of CFTR Protein Renal Phosphate Ion Absorption Positive Regulation Of Voltage-gated Chloride Channel Activity Monocarboxylic Acid Transport Spermatid Development Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Spermatid Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Positive Regulation Of Ion Transport Regulation Of Chloride Transport Germ Cell Development Inorganic Anion Transport Regulation Of Intracellular Protein Transport Cellular Protein Localization Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Iodide Transport Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Lipid Transport Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Sodium Ion Transmembrane Transport Lipid Localization Transepithelial Chloride Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Golgi To Plasma Membrane Protein Transport Ion Transport Negative Regulation Of Transport Bile Acid Secretion Carnitine Transport Oligopeptide Transport Regulation Of Intracellular Transport Transport Protein Localization Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Ion Homeostasis Transepithelial Transport	Anion Transport Transmembrane Transport Anion Transmembrane Transport Organic Anion Transport Ion Transport Ion Transmembrane Transport Homeostatic Process Chemical Homeostasis Ion Homeostasis Monocarboxylic Acid Transport Inorganic Anion Transport Transport Organic Acid Transport Anion Homeostasis Urate Metabolic Process Sodium Ion Transport Cellular Ion Homeostasis Cellular Homeostasis Lipid Transport Regulation Of PH Carboxylic Acid Transport Response To Drug Cellular Chemical Homeostasis Lipid Localization Monovalent Inorganic Cation Transport Antibiotic Transport Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Intracellular PH Regulation Of Cellular PH Sterol Metabolic Process Drug Transport Cellular Phosphate Ion Homeostasis Intracellular PH Elevation Cell Maturation Sodium-dependent Phosphate Transport Transepithelial Chloride Transport Neuron Remodeling Secretion Cholesterol Transport Sterol Transport Oligopeptide Transport Carnitine Transmembrane Transport Carnitine Transport Small Molecule Metabolic Process Transepithelial Transport Phosphate Ion Homeostasis Phosphate Ion Transmembrane Transport Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Peptide Transport
Tagcloud ?		10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Difference) ?		10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage	across agr2 assigned differently effector endocrine ergs estradiol exploitable greb1 interpretation menstrual mirroring pgr premenopausal progesterone rankl responsiveness rhythm runx1 serpina3 serpina5 tff1 tumours varies w1 w2 w3 windows
Tagcloud (Intersection) ?