CLCN3 and GOPC

Number of citations of the paper that reports this interaction (PMID 9843494)
82

Data Source:
HPRD (in vitro, in vivo)

		CLCN3	GOPC
Gene Name		chloride channel, voltage-sensitive 3	golgi-associated PDZ and coiled-coil motif containing
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Synaptic Vesicle External Side Of Plasma Membrane Cell Surface Vesicle Membrane Membrane Integral Component Of Membrane Apical Plasma Membrane Secretory Granule Transport Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Late Endosome Membrane Specific Granule Phagocytic Vesicle	Golgi Membrane Cytoplasm Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Cell Junction Trans-Golgi Network Transport Vesicle Dendrite Protein Complex Postsynaptic Membrane
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Antiporter Activity PDZ Domain Binding Protein Homodimerization Activity Protein Heterodimerization Activity Volume-sensitive Chloride Channel Activity	Small GTPase Regulator Activity Frizzled Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Ion Channel Binding
	Biological Process	Transport Regulation Of PH Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Anion Transport Negative Regulation Of Cell Volume Endosomal Lumen Acidification Transmembrane Transport Chloride Transmembrane Transport	ER To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Spermatid Nucleus Differentiation Protein Transport Cytoplasmic Sequestering Of CFTR Protein Apical Protein Localization Regulation Of Catalytic Activity Protein Homooligomerization
Pathways		Ion channel transport Stimuli-sensing channels
Drugs
Diseases
GWAS			Colorectal cancer ( 23266556)
Protein-Protein Interactions		4 interactors: CFTR GOPC PDZK1 SLC9A3R1	58 interactors: ABCA1 ADRB1 AKIRIN1 ASIC3 BATF BECN1 C17orf67 CCDC102B CD300C CDC42 CDKN2C CERCAM CFTR CLCN3 CSPG5 DPYD FAM90A1 FAM9B FOSL2 FZD5 FZD8 GOLGA3 GRID1 GRID2 HCK IGHG3 JUN KPNA1 LCLAT1 MORN4 MRPL1 MUM1 MYLK MYOCD NUP62 PARK7 PID1 RELA RHOQ RNF183 RNF220 RPL13AP17 RTKN SEMA4G SLC25A18 SPATA8 SSNA1 SSTR5 STARD3 STX6 TGFBR2 VIM VTN ZBTB49 ZNF564 ZNF581 ZNF587 ZSCAN1
Entrez ID		1182	57120
HPRD ID		02785	06024
Ensembl ID		ENSG00000109572	ENSG00000047932
Uniprot IDs		B3KXK0 B9EGJ9 P51790	Q9HD26
PDB IDs			2DC2 2LOB 4E34 4E35
Enriched GO Terms of Interacting Partners?		Regulation Of Ion Transmembrane Transport Organic Anion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Anion Transport Cytoplasmic Sequestering Of CFTR Protein Renal Phosphate Ion Absorption Positive Regulation Of Voltage-gated Chloride Channel Activity Monocarboxylic Acid Transport Spermatid Development Regulation Of Anion Transport Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Spermatid Differentiation Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Positive Regulation Of Ion Transport Regulation Of Chloride Transport Germ Cell Development Inorganic Anion Transport Regulation Of Intracellular Protein Transport Cellular Protein Localization Renal Sodium Ion Transport Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Iodide Transport Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Lipid Transport Carboxylic Acid Transport Organic Acid Transport Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Sodium Ion Transmembrane Transport Lipid Localization Transepithelial Chloride Transport Phospholipase C-activating Dopamine Receptor Signaling Pathway Regulation Of Golgi To Plasma Membrane Protein Transport Ion Transport Negative Regulation Of Transport Bile Acid Secretion Carnitine Transport Oligopeptide Transport Regulation Of Intracellular Transport Transport Protein Localization Negative Regulation Of Sodium Ion Transport Renal Absorption Regulation Of Proton Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Ion Homeostasis Transepithelial Transport	Cellular Response To Stimulus Cellular Response To Organic Substance Response To External Stimulus Myeloid Leukocyte Differentiation Leukocyte Differentiation Response To Organic Substance Cell Surface Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Regulation Of Protein Phosphorylation Response To Stimulus Cellular Process Cell Communication Positive Regulation Of Cellular Biosynthetic Process Regulation Of Binding Positive Regulation Of Transport Regulation Of Cellular Process Cell Differentiation Regulation Of Membrane Potential Myeloid Dendritic Cell Differentiation Cellular Response To Hormone Stimulus Signal Transduction Blood Vessel Morphogenesis Myeloid Dendritic Cell Activation Positive Regulation Of Cellular Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of DNA Binding Response To Extracellular Stimulus Negative Regulation Of Protein Phosphorylation Cell Death Death Positive Regulation Of Gene Expression T-helper 17 Cell Lineage Commitment Response To Lipid Regulation Of Phosphorylation Cellular Localization Membrane Hyperpolarization Negative Regulation Of Cell Proliferation Defense Response Regulation Of Signaling Response To Drug Positive Regulation Of DNA Binding Blood Vessel Development Response To Mechanical Stimulus Response To Stress Signaling Response To Cytokine T-helper 17 Cell Differentiation Dendritic Cell Differentiation Response To Other Organism
Tagcloud ?		10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage	admissions attained clinicaltrials clinics dbp empowering empowerment equation estimating estimation generalized gov hba1c hong inpatient kong nct01935349 outpatient pep programme registration sbp september service sopc specialist t2dm utilization visits
Tagcloud (Difference) ?		10mum 200mum 3mum bkca blockers cardiac channels clamp conductance currents dids diisothiocyanatostilbene disodium disulfonic fibroblasts g0 gated heterogeneously kca1 knock na patch paxilline remarkably sirnas tetrodotoxin vol voltage	admissions attained clinicaltrials clinics dbp empowering empowerment equation estimating estimation generalized gov hba1c hong inpatient kong nct01935349 outpatient pep programme registration sbp september service sopc specialist t2dm utilization visits
Tagcloud (Intersection) ?