AKAP10 and PRKAR1A

Number of citations of the paper that reports this interaction (PubMedID 9326583)
29

Data Source:
HPRD (two hybrid, in vitro)

		AKAP10	PRKAR1A
Description		A-kinase anchoring protein 10	protein kinase cAMP-dependent type I regulatory subunit alpha
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Protein-containing Complex	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Plasma Membrane Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Synapse Ciliary Base Glutamatergic Synapse Sperm Head-tail Coupling Apparatus
	Molecular Function	Protein Binding Protein Kinase A Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Intracellular Protein Localization	Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Development Negative Regulation Of Gene Expression Positive Regulation Of Insulin Secretion Intracellular Signal Transduction Sarcomere Organization Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases			Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Mean platelet volume ( 27863252) Neutrophil count ( 32888494) Platelet count ( 22139419 27863252 32888494) Schizophrenia ( 28991256) Strenuous sports or other exercises ( 29899525)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		7 interacting genes: IKZF3 NHERF1 PDZK1 PRKAR1A PRKAR2A PRKAR2B SASH1	55 interacting genes: AKAP1 AKAP10 AKAP11 AKAP19 AKAP4 AKAP5 AKAP7 AKT1 ARFGEF2 BAHD1 BTG3 CAPN11 CBS CCNE1 CDK2 CDK4 CSTPP1 DSCR4 DSCR9 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAP1A MAP1B MAPK6 MYO7A NELL2 OGT PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PSMG1 PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SNCA SPART TAB1 WDCP WNK1 YWHAZ ZBED1
Entrez ID		11216	5573
HPRD ID		05259	01786
Ensembl ID		ENSG00000108599	ENSG00000108946
Uniprot IDs		A0A0S2Z4Z7 A0A0S2Z513 E7EMD6 O43572	B2R5T5 P10644
PDB IDs		3IM4 3TMH	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ciliary Base Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Nucleotide-activated Protein Kinase Complex Microvillus Membrane Protein-membrane Adaptor Activity Plasma Membrane Raft Protein Domain Specific Binding Negative Regulation Of Intracellular Signal Transduction Brush Border Membrane G Protein-coupled Receptor Signaling Pathway Renal Phosphate Ion Absorption PDZ Domain Binding Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Response To Antipsychotic Drug Edg-2 Lysophosphatidic Acid Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Extracellular Exosome Regulation Of Cell Communication Regulation Of Signaling Axoneme Type 3 Metabotropic Glutamate Receptor Binding Localization Within Membrane Scavenger Receptor Binding Protein Localization To Plasma Membrane Carnitine Transmembrane Transport Carnitine Transport Negative Regulation Of Signal Transduction Centrosome Negative Regulation Of Cell Communication Regulation Of Secretion Negative Regulation Of Signaling Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Molecular Adaptor Activity	Protein Kinase A Regulatory Subunit Binding CAMP-dependent Protein Kinase Complex Protein Kinase A Binding Protein Phosphorylation Cytosol Phosphorylation Protein-containing Complex Ubiquitin Protein Ligase Binding Cytoplasm Peptidyl-serine Phosphorylation Regulation Of Protein Localization To Cell Periphery Protein Serine Kinase Activity Intracellular Signal Transduction Regulation Of Biological Quality Signal Transduction Kinase Activity Protein Kinase Activity Cyclin E1-CDK2 Complex Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Protein Serine/threonine Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation TORC1 Signaling Regulation Of Lymphocyte Migration Intracellular Signaling Cassette Postsynapse Cellular Response To Oxygen-containing Compound Protein Kinase Binding Intracellular Protein Localization Protein Domain Specific Binding Cell Surface Receptor Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Localization To Cell Periphery ERBB Signaling Pathway Regulation Of Anaphase-promoting Complex-dependent Catabolic Process CAMP-dependent Protein Kinase Activity Establishment Of Protein Localization TOR Signaling Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Protein Catabolic Process Negative Regulation Of Catabolic Process Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of T Cell Migration Odontoblast Differentiation Regulation Of Protein Kinase A Signaling Organelle Organization Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Protein Localization To Membrane Enzyme Binding
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