AKAP10 and PRKAR2B

Number of citations of the paper that reports this interaction (PubMedID 9326583)
29

Data Source:
HPRD (in vitro)

		AKAP10	PRKAR2B
Description		A-kinase anchoring protein 10	protein kinase cAMP-dependent type II regulatory subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Protein-containing Complex	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Membrane Dendrite Neuronal Cell Body Dendritic Spine Dendritic Shaft Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Kinase A Binding	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Intracellular Protein Localization	Fatty Acid Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Learning Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Response To Antipsychotic Drug Negative Regulation Of CAMP/PKA Signal Transduction
Pathways		Factors involved in megakaryocyte development and platelet production	PKA activation PKA activation in glucagon signalling DARPP-32 events Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Cyclic adenosine monophosphate
Diseases
GWAS		Body mass index ( 29273807) Brain morphology (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Mean platelet volume ( 27863252) Neutrophil count ( 32888494) Platelet count ( 22139419 27863252 32888494) Schizophrenia ( 28991256) Strenuous sports or other exercises ( 29899525)	Adverse response to lamotrigine and phenytoin ( 22379998) Bladder cancer (smoking interaction) ( 24662972) Blood urea nitrogen levels ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 28552196) Manganese levels ( 26025379) Response to antipsychotic treatment ( 20195266) Triglyceride levels ( 32203549)
Interacting Genes		7 interacting genes: IKZF3 NHERF1 PDZK1 PRKAR1A PRKAR2A PRKAR2B SASH1	17 interacting genes: AKAP1 AKAP10 AKAP11 AKAP14 AKAP19 AKAP4 AKAP5 AKAP9 CFAP91 ECM1 GNAI3 KIF5B LASP1 NBEA OGT PAK1IP1 TAF12
Entrez ID		11216	5577
HPRD ID		05259	01486
Ensembl ID		ENSG00000108599	ENSG00000005249
Uniprot IDs		A0A0S2Z4Z7 A0A0S2Z513 E7EMD6 O43572	B3KY43 P31323
PDB IDs		3IM4 3TMH
Enriched GO Terms of Interacting Partners?		CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Ciliary Base Regulation Of CAMP/PKA Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Nucleotide-activated Protein Kinase Complex Microvillus Membrane Protein-membrane Adaptor Activity Plasma Membrane Raft Protein Domain Specific Binding Negative Regulation Of Intracellular Signal Transduction Brush Border Membrane G Protein-coupled Receptor Signaling Pathway Renal Phosphate Ion Absorption PDZ Domain Binding Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Response To Antipsychotic Drug Edg-2 Lysophosphatidic Acid Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Extracellular Exosome Regulation Of Cell Communication Regulation Of Signaling Axoneme Type 3 Metabotropic Glutamate Receptor Binding Localization Within Membrane Scavenger Receptor Binding Protein Localization To Plasma Membrane Carnitine Transmembrane Transport Carnitine Transport Negative Regulation Of Signal Transduction Centrosome Negative Regulation Of Cell Communication Regulation Of Secretion Negative Regulation Of Signaling Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Molecular Adaptor Activity	Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Negative Regulation Of Adenylate Cyclase Activity CAMP-dependent Protein Kinase Complex
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