AKAP10 and PRKAR2B

Number of citations of the paper that reports this interaction (PMID 9326583)
39

Data Source:
HPRD (in vitro)

		AKAP10	PRKAR2B
Gene Name		A kinase (PRKA) anchor protein 10	protein kinase, cAMP-dependent, regulatory, type II, beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol Plasma Membrane	Cytoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Dendritic Spine Dendritic Shaft Extracellular Vesicular Exosome Ciliary Base
	Molecular Function		CAMP-dependent Protein Kinase Inhibitor Activity CAMP-dependent Protein Kinase Regulator Activity CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Signal Transduction Blood Coagulation Protein Localization Termination Of G-protein Coupled Receptor Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Renal Water Homeostasis Energy Reserve Metabolic Process Fatty Acid Metabolic Process Water Transport Organelle Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Blood Coagulation Learning Fibroblast Growth Factor Receptor Signaling Pathway Activation Of Protein Kinase A Activity Intracellular Signal Transduction Small Molecule Metabolic Process Innate Immune Response Neurotrophin TRK Receptor Signaling Pathway Regulation Of Insulin Secretion Transmembrane Transport Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Factors involved in megakaryocyte development and platelet production	Ca-dependent events Signaling by GPCR CaM pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Hedgehog 'off' state Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by EGFRvIII in Cancer Regulation of PLK1 Activity at G2/M Transition PLCG1 events in ERBB2 signaling DAP12 signaling Recruitment of mitotic centrosome proteins and complexes Glucagon signaling in metabolic regulation Signaling by PDGF Calmodulin induced events DAP12 interactions PKA-mediated phosphorylation of CREB Opioid Signalling PKA activation Factors involved in megakaryocyte development and platelet production Aquaporin-mediated transport EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR PKA-mediated phosphorylation of CREB Calmodulin induced events Downstream signal transduction Signaling by EGFR in Cancer PKA activation Mitotic G2-G2/M phases Organelle biogenesis and maintenance G2/M Transition DAG and IP3 signaling CaM pathway Downstream signaling of activated FGFR Loss of Nlp from mitotic centrosomes DARPP-32 events Innate Immune System PKA activation in glucagon signalling Signalling by NGF PLC beta mediated events Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer Assembly of the primary cilium G-protein mediated events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Signaling by FGFR Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog PLC-gamma1 signalling Centrosome maturation
Drugs
Diseases
GWAS		Platelet counts ( 22139419)	Adverse response to lamotrigine and phenytoin ( 22379998) Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		5 interactors: PDZK1 PRKAR1A PRKAR2A PRKAR2B SLC9A3R1	14 interactors: AKAP1 AKAP10 AKAP11 AKAP14 AKAP4 AKAP5 AKAP7 AKAP9 GNAI3 KIF5B LASP1 MAATS1 NBEA TAF12
Entrez ID		11216	5577
HPRD ID		05259	01486
Ensembl ID		ENSG00000108599	ENSG00000005249
Uniprot IDs		O43572	B3KY43 P31323
PDB IDs		3IM4 3TMH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of CAMP-dependent Protein Kinase Activity Regulation Of CAMP-dependent Protein Kinase Activity Renal System Process Activation Of Protein Kinase A Activity Renal Water Homeostasis Cellular Response To Glucagon Stimulus Water Transport Fluid Transport Activation Of Phospholipase C Activity Multicellular Organismal Water Homeostasis Response To Glucagon Positive Regulation Of Phospholipase C Activity Water Homeostasis Positive Regulation Of Phospholipase Activity Negative Regulation Of Phosphorylation Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Energy Reserve Metabolic Process Regulation Of Protein Transport Regulation Of Secretion Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Regulation Of Kinase Activity Regulation Of Protein Localization Negative Regulation Of Protein Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Chemical Homeostasis Regulation Of Hormone Secretion Activation Of Protein Kinase Activity Regulation Of Cellular Localization Negative Regulation Of Transferase Activity Energy Derivation By Oxidation Of Organic Compounds Regulation Of Protein Phosphorylation Negative Regulation Of Protein Phosphorylation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Protein Secretion Regulation Of Phosphorylation Generation Of Precursor Metabolites And Energy Homeostatic Process	Regulation Of Protein Kinase A Signaling Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Membrane Repolarization Regulation Of Potassium Ion Transmembrane Transporter Activity Positive Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transport Cellular Response To CAMP Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Membrane Potential Positive Regulation Of Transporter Activity Positive Regulation Of Ion Transmembrane Transport Regulation Of CAMP Biosynthetic Process Stress Granule Disassembly Regulation Of CAMP Metabolic Process Blood Coagulation Hemostasis Response To CAMP Positive Regulation Of Delayed Rectifier Potassium Channel Activity Protein Localization Positive Regulation Of Protein Kinase A Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Organophosphorus Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Body Fluid Levels Regulation Of Signaling Synaptic Transmission Wound Healing Response To Purine-containing Compound Cytoplasm Organization Regulation Of Ion Transport Regulation Of Delayed Rectifier Potassium Channel Activity Response To Wounding Positive Regulation Of Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sexual Reproduction Positive Regulation Of Synaptic Transmission, GABAergic Transport
Tagcloud ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Difference) ?			agouti albinism asip atf1 delta25 dopachrome edn1 edn3 ednrb exoc2 exocyst kitlg ludwigshafen mc1r microphthalmia oca2 oculocutaneous pigmentation prkacg proopiomelanocortin slc24a4 slc45a2 tautomerase tpcn2 tubb3 tyrp1
Tagcloud (Intersection) ?