ABCC4 and ERBB2IP

Number of citations of the paper that reports this interaction (PMID 15123239)
9

Data Source:
BioGRID (unspecified method)

		ABCC4	ERBB2IP
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 4	erbb2 interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Platelet Dense Granule Membrane	Basement Membrane Nucleus Nucleoplasm Cytoplasm Plasma Membrane Basal Plasma Membrane Cell Junction Hemidesmosome Nuclear Membrane
	Molecular Function	ATP Binding 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	ErbB-2 Class Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Platelet Degranulation Blood Coagulation Biological_process Response To Organonitrogen Compound Response To Organic Cyclic Compound Platelet Activation Response To Drug Positive Regulation Of Smooth Muscle Cell Proliferation Transmembrane Transport Oxidation-reduction Process	Protein Targeting Cell Cycle Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Growth Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Pathways		ABC-family proteins mediated transport Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Signaling by ERBB2
Drugs
Diseases
GWAS		Breast cancer ( 17903305) Longevity ( 20834067) Platelet counts ( 22139419) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653)
Protein-Protein Interactions		5 interactors: ERBB2IP PDZK1 SLC9A3R1 SLC9A3R2 SNTA1	62 interactors: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 NOD2 NR2E1 PICK1 PKP4 RAF1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		10257	55914
HPRD ID		05583	06090
Ensembl ID		ENSG00000125257	ENSG00000112851
Uniprot IDs		B7Z3Q7 O15439	B4DIP2 Q96RT1
PDB IDs			1MFG 1MFL 1N7T 2H3L 2QBW 3CH8
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Ion Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Renal Phosphate Ion Absorption Monocarboxylic Acid Transport Basal Protein Localization Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Negative Regulation Of Peptidyl-cysteine S-nitrosylation Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Protein Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion Oligopeptide Transport Carnitine Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Phosphate Ion Homeostasis Negative Regulation Of Intracellular Signal Transduction Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Organic Anion Transport Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Ventricular Cardiac Muscle Cell Action Potential Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization Regulation Of Membrane Repolarization Regulation Of Excretion Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Positive Regulation Of Protein Targeting To Membrane Monovalent Inorganic Cation Transport	Regulation Of Signaling Response To Stimulus Response To Organic Substance Signaling Cellular Response To Growth Factor Stimulus Cell Communication Response To Growth Factor Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Response To Stress Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Junction Assembly Regulation Of Cell Proliferation SMAD Protein Complex Assembly Negative Regulation Of Cell Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Movement Signal Transduction Cellular Response To Organic Cyclic Compound Organ Development Anatomical Structure Morphogenesis Cellular Component Assembly Cell-cell Junction Organization Positive Regulation Of Transcription, DNA-templated Renal System Development Negative Regulation Of Signaling Regulation Of Cell Motility Gastrulation Cell-cell Signaling Regulation Of Cell Differentiation Negative Regulation Of Signal Transduction Regulation Of Locomotion Response To Wounding Urogenital System Development Regulation Of Cell Migration System Development Regulation Of Epithelial Cell Proliferation Adherens Junction Organization Positive Regulation Of Macromolecule Biosynthetic Process Intracellular Signal Transduction Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Kidney Development Positive Regulation Of Gene Expression Response To Organic Cyclic Compound Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Difference) ?		abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters	adoptive cd4 cholangiocarcinoma contained exists exomic experienced harnessed helper humans infiltrating interacting lymphocytes mediate metastatic mount mutated mutation polyfunctional prolonged pure recognizing regression retreated sequencing stabilization til transfer
Tagcloud (Intersection) ?