ABCC4 and ERBIN

Number of citations of the paper that reports this interaction (PubMedID 15123239)
0

Data Source:
BioGRID (unspecified method)

		ABCC4	ERBIN
Description		ATP binding cassette subfamily C member 4 (PEL blood group)	erbb2 interacting protein
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GO Annotations	Cellular Component	Nucleolus Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Platelet Dense Granule Membrane External Side Of Apical Plasma Membrane	Basement Membrane Nucleus Cytoplasm Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Nuclear Speck Cell Junction Hemidesmosome Neuromuscular Junction Nuclear Membrane Anchoring Junction Postsynapse Glutamatergic Synapse Postsynaptic Specialization
	Molecular Function	Nucleotide Binding Guanine Nucleotide Transmembrane Transporter Activity Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Prostaglandin Transmembrane Transporter Activity Urate Transmembrane Transporter Activity Purine Nucleotide Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity Efflux Transmembrane Transporter Activity 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATP Hydrolysis Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity	Signaling Receptor Binding ErbB-2 Class Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding
	Biological Process	Platelet Degranulation Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid And Bile Salt Transport Prostaglandin Transport Urate Transport Prostaglandin Secretion Glutathione Transmembrane Transport Transmembrane Transport Cilium Assembly CAMP Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Guanine Nucleotide Transmembrane Transport	Protein Targeting Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Gene Expression Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Response To Lipopolysaccharide Intracellular Signal Transduction Intermediate Filament Cytoskeleton Organization Basal Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Tumor Necrosis Factor Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		Platelet degranulation ABC-family proteins mediated transport Azathioprine ADME Paracetamol ADME	Signaling by ERBB2 Downregulation of ERBB2 signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		ATP
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Breast cancer ( 17903305) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 20834067) Parent of origin effect on language impairment (paternal) ( 24571439) Platelet count ( 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653) Serum metabolite levels ( 33031748)	Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		6 interacting genes: ERBIN MPP1 NHERF1 NHERF2 PDZK1 SNTA1	66 interacting genes: ABCA1 ABCC4 ABR ACTN1 ACTN2 ACVR2A ACVR2B AGTR2 APC ARHGEF7 ARVCF ATP2B1 ATP2B2 ATP2B4 BANF1 CASK CDH1 CHUK COPB1 CTNNB1 CTNND1 CTNND2 CTSG DLG4 DST ERBB2 FOXO3 GRIN2B GRIN2C GUCY1A2 ITGB4 KCNA4 KCNA5 LAMB1 LMO1 LMO2 LRRC1 MAP4 MAPK12 MCC MEF2A MPP1 MPP2 MPP3 MUSK NOD2 NR2E1 PICK1 PKP4 RAF1 RBX1 RNF7 RPS6KA1 SCN4A SHOC2 SLC5A5 SLC5A6 SLC6A12 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 STAT3 VIPR2 ZFYVE9
Entrez ID		10257	55914
HPRD ID		05583	06090
Ensembl ID		ENSG00000125257	ENSG00000112851
Uniprot IDs		A8K2Q2 O15439	A0A8V8TML4 A0A8V8TPC7 Q96RT1
PDB IDs		8BJF 8BWO 8BWP 8BWQ 8BWR 8I4A 8I4B 8I4C 8IZ7 8IZ8 8IZ9 8IZA 8J3W 8J3Z 8XOK 8XOL 8XOM	1MFG 1MFL 1N7T 2H3L 2QBW 3CH8 6Q0M 6Q0N 6Q0U 6UBH 7LUL
Enriched GO Terms of Interacting Partners?		Signaling Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding PDZ Domain Binding Protein Localization To Plasma Membrane Microvillus Membrane Protein Localization To Cell Periphery Stereocilium Protein Localization To Membrane Brush Border Membrane Phosphatase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Apical Plasma Membrane Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Plasma Membrane Neuromuscular Junction Renal Phosphate Ion Absorption Localization Within Membrane Beta-catenin Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Basal Protein Localization ErbB-2 Class Receptor Binding Intracellular Protein Localization Scavenger Receptor Binding Syntrophin Complex Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Molecular Adaptor Activity Growth Factor Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Negative Regulation Of Monocyte Chemotactic Protein-1 Production Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Hemidesmosome GMP Kinase Activity Intracellular Phosphate Ion Homeostasis	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane I-SMAD Binding Enzyme-linked Receptor Protein Signaling Pathway Heteromeric SMAD Protein Complex Intracellular Signaling Cassette Regulation Of Cell Communication Regulation Of Signaling Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Basolateral Plasma Membrane Cell Junction Organization Adherens Junction Trophoblast Cell Migration SMAD Protein Complex Regulation Of Signal Transduction Regulation Of System Process Gastrulation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway SMAD Protein Signal Transduction Embryonic Foregut Morphogenesis Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Anchoring Junction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Multicellular Organismal Process Cell Junction Assembly Cell Junction Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Developmental Process Protein Kinase Binding Positive Regulation Of RNA Metabolic Process MAPK Cascade Cell-substrate Junction Assembly Response To Growth Factor Metal Ion Transport Transcription Regulator Complex Gastrulation With Mouth Forming Second Cell-substrate Junction Organization Positive Regulation Of Developmental Process Negative Regulation Of Developmental Process Negative Regulation Of Ossification Regulation Of Biological Quality Positive Regulation Of Multicellular Organismal Process Cell Projection Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Differentiation
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