ABCC4 and SLC9A3R1

Number of citations of the paper that reports this interaction (PMID 18559527)
9

Data Source:
BioGRID (pull down)

		ABCC4	SLC9A3R1
Gene Name		ATP-binding cassette, sub-family C (CFTR/MRP), member 4	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Platelet Dense Granule Membrane	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece
	Molecular Function	ATP Binding 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding
	Biological Process	Platelet Degranulation Blood Coagulation Biological_process Response To Organonitrogen Compound Response To Organic Cyclic Compound Platelet Activation Response To Drug Positive Regulation Of Smooth Muscle Cell Proliferation Transmembrane Transport Oxidation-reduction Process	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		ABC-family proteins mediated transport Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Breast cancer ( 17903305) Longevity ( 20834067) Platelet counts ( 22139419) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653)	Fibrinogen ( 20031577)
Protein-Protein Interactions		5 interactors: ERBB2IP PDZK1 SLC9A3R1 SLC9A3R2 SNTA1	52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468
Entrez ID		10257	9368
HPRD ID		05583	05406
Ensembl ID		ENSG00000125257	ENSG00000109062
Uniprot IDs		B7Z3Q7 O15439	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Regulation Of Sodium Ion Transport Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Ion Transport Regulation Of Vasoconstriction By Circulating Norepinephrine Renal Phosphate Ion Absorption Monocarboxylic Acid Transport Basal Protein Localization Glutathione Transport Negative Regulation Of Sodium:proton Antiporter Activity Renal Sodium Ion Transport Negative Regulation Of Peptidyl-cysteine S-nitrosylation Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Protein Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Bile Acid Secretion Oligopeptide Transport Carnitine Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Phosphate Ion Homeostasis Negative Regulation Of Intracellular Signal Transduction Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Organic Anion Transport Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Quaternary Ammonium Group Transport Ventricular Cardiac Muscle Cell Action Potential Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization Regulation Of Membrane Repolarization Regulation Of Excretion Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Bile Acid And Bile Salt Transport Positive Regulation Of Protein Targeting To Membrane Monovalent Inorganic Cation Transport	Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process
Tagcloud ?		abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters	adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Difference) ?		abcb1 antagonize antioxidants caco cassette chemoresistance cnts concurrently devices dimethylthiourea extrusion forced hold integral mdr mecaptoethanol mrp4 multiwalled mwcnt mwcnts nanotubes overcome pgp promise proto shed transporter transporters	adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Intersection) ?