WBP11 and WBP4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid, two hybrid, pull down)

		WBP11	WBP4
Description		WW domain binding protein 11	WW domain binding protein 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Proline-rich Region Binding
	Biological Process	RRNA Processing RNA Processing MRNA Processing RNA Splicing	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing MRNA Cis Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)
Interacting Genes		37 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CEBPA CTNNBL1 DDX17 DDX5 FOXP1 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PCBP4 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRMT2 PRPF40A RBM5 RSPH1 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4	66 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 CSDE1 DDX23 DDX3X DHX15 DHX38 DIAPH1 DMRTB1 DNM2 EFTUD2 EIF4ENIF1 EIF5B EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 LARP4 NONO OGT PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 RARS1 RBM22 RBM42 RBPMS SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP27 SNRNP70 SNRPA SNRPB SNW1 SQSTM1 TCERG1 TFIP11 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207
Entrez ID		51729	11193
HPRD ID		18293	16086
Ensembl ID		ENSG00000084463	ENSG00000120688
Uniprot IDs		Q9Y2W2	O75554
PDB IDs		7ABF 7ABG	2DK1 2JXW 5O9Z 6AHD 7OS1 8H6K 8H6L 8Q7N 8QO9 8QPE 8QZS
Enriched GO Terms of Interacting Partners?		Nuclear Speck Proline-rich Region Binding Cytosol RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome PTW/PP1 Phosphatase Complex Nucleus RNA Splicing Ribonucleoprotein Complex Binding Cytoplasm Regulation Of RNA Splicing Nucleoplasm MRNA Processing Protein Domain Specific Binding Regulation Of Defense Response Protein-containing Complex Binding Regulation Of Gene Expression Scaffold Protein Binding Entrainment Of Circadian Clock By Photoperiod Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Nuclear Androgen Receptor Binding Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ephrin Receptor Binding Photoperiodism Entrainment Of Circadian Clock Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process MRNA Metabolic Process Regulation Of Innate Immune Response Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Neurotrophin TRKA Receptor Binding Regulation Of MRNA Metabolic Process Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Developmental Process Regulation Of Immune System Process Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Signal Complex Assembly T Cell Costimulation	MRNA Processing MRNA Metabolic Process RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Binding Spliceosomal Complex RNA Processing RNA Metabolic Process Nucleic Acid Binding Catalytic Step 2 Spliceosome Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleoplasm Nucleus Nuclear Speck U2-type Precatalytic Spliceosome Macromolecule Metabolic Process U4/U6 X U5 Tri-snRNP Complex MRNA Binding U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Poly(A) Binding Protein-containing Complex Assembly Cellular Component Assembly Protein-containing Complex Organization Regulation Of MRNA Splicing, Via Spliceosome U12-type Spliceosomal Complex Regulation Of MRNA Processing Cytoplasmic Stress Granule MRNA 3'-splice Site Recognition MRNA Cis Splicing, Via Spliceosome U2-type Prespliceosome Membraneless Organelle Assembly Paraspeckles Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Translation Pre-mRNA Binding Nuclear Matrix U1 SnRNP U1 SnRNP Binding Positive Regulation Of Translation Protein Binding
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