WBP11 and GIGYF2

Number of citations of the paper that reports this interaction (PubMedID 16120600)
0

Data Source:
HPRD (two hybrid)

		WBP11	GIGYF2
Description		WW domain binding protein 11	GRB10 interacting GYF protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Vesicle Protein-containing Complex Perikaryon Proximal Dendrite
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding	RNA Binding Protein Binding Cadherin Binding Molecular Adaptor Activity Proline-rich Region Binding
	Biological Process	RRNA Processing RNA Processing MRNA Processing RNA Splicing	Feeding Behavior Adult Locomotory Behavior Post-embryonic Development Post-transcriptional Gene Silencing Negative Regulation Of Translation Spinal Cord Motor Neuron Differentiation Mitotic G1 DNA Damage Checkpoint Signaling Multicellular Organism Growth Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuromuscular Process Controlling Balance Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Rescue Of Stalled Ribosome
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases			Parkinson's disease (PD)
GWAS		Hip circumference adjusted for BMI ( 34021172)	Anxiety and stress-related disorders ( 31116379) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Schizophrenia ( 23974872 25056061 29483656)
Interacting Genes		37 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CEBPA CTNNBL1 DDX17 DDX5 FOXP1 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PCBP4 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRMT2 PRPF40A RBM5 RSPH1 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4	12 interacting genes: APC CNOT9 CRYAA GRB10 GRB14 GRB7 RBM12 RNF10 SNRPB UBC USP7 WBP11
Entrez ID		51729	26058
HPRD ID		18293	11639
Ensembl ID		ENSG00000084463	ENSG00000204120
Uniprot IDs		Q9Y2W2	Q6Y7W6
PDB IDs		7ABF 7ABG	5NVL 5NVM 7RUP
Enriched GO Terms of Interacting Partners?		Nuclear Speck Proline-rich Region Binding Cytosol RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome PTW/PP1 Phosphatase Complex Nucleus RNA Splicing Ribonucleoprotein Complex Binding Cytoplasm Regulation Of RNA Splicing Nucleoplasm MRNA Processing Protein Domain Specific Binding Regulation Of Defense Response Protein-containing Complex Binding Regulation Of Gene Expression Scaffold Protein Binding Entrainment Of Circadian Clock By Photoperiod Alternative MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Nuclear Androgen Receptor Binding Regulation Of Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ephrin Receptor Binding Photoperiodism Entrainment Of Circadian Clock Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process MRNA Metabolic Process Regulation Of Innate Immune Response Regulation Of Programmed Cell Death Positive Regulation Of Immune System Process Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Regulation Of Macromolecule Metabolic Process Neurotrophin TRKA Receptor Binding Regulation Of MRNA Metabolic Process Regulation Of Caveolin-mediated Endocytosis Osteoclast Development Regulation Of Nucleobase-containing Compound Metabolic Process Protein Binding Regulation Of Developmental Process Regulation Of Immune System Process Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Signal Complex Assembly T Cell Costimulation	Insulin Receptor Signaling Pathway Lens Fiber Cell Morphogenesis Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Leading Edge Membrane Cytosol Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Protein Methylation
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