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PDGFB and COL4A1
Number of citations of the paper that reports this interaction (PubMedID
8900172
)
0
Data Source:
BioGRID
(pull down, far western blotting)
PDGFB
COL4A1
Description
platelet derived growth factor subunit B
collagen type IV alpha 1 chain
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Membrane
Basolateral Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Platelet-derived Growth Factor Complex
Extracellular Region
Collagen Trimer
Collagen Type IV Trimer
Basement Membrane
Endoplasmic Reticulum Lumen
Extracellular Matrix
Molecular Function
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Receptor Ligand Activity
Platelet-derived Growth Factor Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Platelet-derived Growth Factor Binding
Biological Process
Angiogenesis
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Gene Expression
Regulation Of Gene Expression
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell-substrate Adhesion
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Brain Development
Neuromuscular Junction Development
Epithelial Cell Differentiation
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Blood Vessel Morphogenesis
Retinal Blood Vessel Morphogenesis
Renal Tubule Morphogenesis
Cellular Response To Amino Acid Stimulus
Basement Membrane Organization
Pathways
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Scavenging by Class A Receptors
NCAM1 interactions
Collagen chain trimerization
Attachment of bacteria to epithelial cells
Drugs
Pegpleranib
Diseases
Glioma
Malignant pleural mesothelioma
Hereditary angiopathy with nephropathy, aneurysms, and muscle cramps (HANAC)
Brain small vessel disease with Axenfeld-Rieger anomaly
Porencephaly
GWAS
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Age-related nuclear cataracts (
24951543
)
Arterial stiffness (
20031579
)
Behavioral disturbance or psychiatric symptoms and prion disease (
25897833
)
Coronary artery disease (
32469254
33020668
24262325
26343387
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
Coronary heart disease (
21378990
)
Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension (
31754133
)
Estimated glomerular filtration rate after 1 year in renal transplantation (donor effect) (
30920136
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Intraocular pressure (
31959993
29785010
)
Lateral ventricle volume (
31530798
)
Liver enzyme levels (gamma-glutamyl transferase) (
33972514
)
Lymphocyte count (
32888494
)
Mean platelet volume (
32888494
)
Metabolite levels (
23823483
)
Monocyte count (
32888494
27863252
)
Myocardial infarction (
33532862
26343387
)
Night sleep phenotypes (
27126917
)
Non-lobar intracerebral hemorrhage (MTAG) (
31430377
)
Obesity-related traits (
23251661
)
Peripheral artery disease (
31285632
)
Platelet count (
32888494
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
)
Pulse pressure (
30578418
)
Stroke (
30383316
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
28552196
34021172
)
Interacting Genes
23 interacting genes:
A2M
ART1
BCCIP
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
30 interacting genes:
ACHE
APCS
APP
BGN
BMP3
CD93
COL18A1
COL4A2
COL7A1
DCN
DISC1
FBLN2
FN1
HABP2
MAG
MATN2
MMP9
NID1
NID2
OSM
PDGFA
PDGFB
SAA1
SAA2
SAA4
SERPINE2
SMAD1
TGFBI
TGM2
THBS1
Entrez ID
5155
1282
HPRD ID
01815
00359
Ensembl ID
ENSG00000100311
ENSG00000187498
Uniprot IDs
A0A384NYY3
P01127
A5PKV2
P02462
PDB IDs
1PDG
3MJG
4HQU
4HQX
4QCI
6T9E
1LI1
5NAX
5NAY
6MPX
Enriched GO Terms of Interacting Partners
?
Platelet-derived Growth Factor Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Collagen Trimer
Extracellular Matrix
Fibrillar Collagen Trimer
Extracellular Matrix Structural Constituent
Basement Membrane
Anatomical Structure Morphogenesis
Endoplasmic Reticulum Lumen
Collagen Fibril Organization
Developmental Process
Extracellular Matrix Organization
Extracellular Structure Organization
Cellular Response To Amino Acid Stimulus
Phospholipase C Activator Activity
Regulation Of Locomotion
Response To Amino Acid
Enzyme-linked Receptor Protein Signaling Pathway
Animal Organ Morphogenesis
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Cell Motility
Positive Regulation Of Locomotion
Anatomical Structure Formation Involved In Morphogenesis
Angiogenesis
Extracellular Region
Protease Binding
Proteoglycan Binding
Skin Development
Cell Differentiation
Collagen Type I Trimer
Collagen V Binding
Cellular Developmental Process
Collagen Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Metanephric Glomerular Capillary Formation
Kinase Regulator Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Extracellular Matrix Assembly
Cell Surface Receptor Signaling Pathway
Response To Wounding
Vascular Endothelial Growth Factor Binding
Basement Membrane Organization
Blood Vessel Morphogenesis
Cartilage Development
Collagen Type XI Trimer
Skeletal System Morphogenesis
Cell Adhesion
Extracellular Region
Extracellular Matrix
Basement Membrane
Collagen Binding
Extracellular Matrix Structural Constituent
Extracellular Space
Extracellular Matrix Binding
Acute-phase Response
Extracellular Exosome
Cell Adhesion
Endoplasmic Reticulum Lumen
Regulation Of Multicellular Organismal Process
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
High-density Lipoprotein Particle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Glycosaminoglycan Binding
Regulation Of Cell Adhesion
Acute Inflammatory Response
Platelet Alpha Granule Lumen
Regulation Of Developmental Process
Extracellular Matrix Organization
Extracellular Structure Organization
Developmental Process
Endodermal Cell Differentiation
Calcium Ion Binding
Golgi Lumen
Anatomical Structure Formation Involved In Morphogenesis
Regulation Of Cell Differentiation
Positive Regulation Of Developmental Process
Proteoglycan Binding
Response To Wounding
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Neurogenesis
Regulation Of Multicellular Organismal Development
Positive Regulation Of Cell-substrate Adhesion
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Multicellular Organismal Process
Inflammatory Response
Negative Regulation Of Platelet Activation
Regulation Of Wound Healing
Platelet Alpha Granule
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Laminin Binding
Negative Regulation Of Wound Healing
Bone Development
Positive Regulation Of Nervous System Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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