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PDGFB and COL1A1
Number of citations of the paper that reports this interaction (PubMedID
10446987
)
0
Data Source:
HPRD
(in vitro)
PDGFB
COL1A1
Description
platelet derived growth factor subunit B
collagen type I alpha 1 chain
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Golgi Lumen
Cell Surface
Membrane
Basolateral Plasma Membrane
Extracellular Matrix
Platelet Alpha Granule Lumen
Platelet-derived Growth Factor Complex
Extracellular Region
Collagen Trimer
Fibrillar Collagen Trimer
Collagen Type I Trimer
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Secretory Granule
Extracellular Matrix
Molecular Function
Platelet-derived Growth Factor Receptor Binding
Protein Binding
Collagen Binding
Growth Factor Activity
Superoxide-generating NADPH Oxidase Activator Activity
Chemoattractant Activity
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Receptor Ligand Activity
Platelet-derived Growth Factor Binding
Protease Binding
Extracellular Matrix Structural Constituent
Protein Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Identical Protein Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Angiogenesis
Embryonic Placenta Development
Positive Regulation Of Endothelial Cell Proliferation
Monocyte Chemotaxis
Positive Regulation Of Glomerular Filtration
Protein Phosphorylation
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Heart Development
Positive Regulation Of Cell Population Proliferation
Response To Wounding
Gene Expression
Regulation Of Gene Expression
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Negative Regulation Of Platelet Activation
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Positive Regulation Of Cell-substrate Adhesion
Smooth Muscle Adaptation
Positive Regulation Of Smooth Muscle Cell Migration
Peptidyl-tyrosine Phosphorylation
Hemopoiesis
Positive Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Cellular Response To Platelet-derived Growth Factor Stimulus
Paracrine Signaling
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Mitotic Nuclear Division
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Chemotaxis
Positive Regulation Of Chemotaxis
Regulation Of Multicellular Organismal Process
Positive Regulation Of Cell Division
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Cell Chemotaxis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Mycophenolic Acid
Positive Regulation Of Glomerular Mesangial Cell Proliferation
Metanephric Glomerular Mesangial Cell Development
Reactive Oxygen Species Metabolic Process
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Hyaluronan Biosynthetic Process
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of MiRNA Transcription
Positive Regulation Of MiRNA Transcription
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Metanephric Mesenchymal Cell Migration
Skeletal System Development
Ossification
Blood Vessel Development
Osteoblast Differentiation
Intramembranous Ossification
Endochondral Ossification
Response To Nutrient
Visual Perception
Sensory Perception Of Sound
Response To Xenobiotic Stimulus
Response To Mechanical Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Cell-substrate Adhesion
Protein Transport
Collagen Fibril Organization
Positive Regulation Of Cell Migration
Response To Nutrient Levels
Response To Estradiol
Response To Insulin
Collagen Biosynthetic Process
Protein Localization To Nucleus
Tooth Mineralization
Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Response To Hydrogen Peroxide
Response To Peptide Hormone
Skin Development
Skin Morphogenesis
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of DNA-templated Transcription
Animal Organ Development
Response To Steroid Hormone
Skeletal System Morphogenesis
Embryonic Skeletal System Development
System Development
Response To CAMP
Response To Hyperoxia
Face Morphogenesis
Bone Trabecula Formation
Cartilage Development Involved In Endochondral Bone Morphogenesis
Cellular Response To Amino Acid Stimulus
Cellular Response To Mechanical Stimulus
Cellular Response To Retinoic Acid
Cellular Response To Vitamin E
Cellular Response To Glucose Stimulus
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Response To Fluoride
Cellular Response To Fluoride
Pathways
Platelet degranulation
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
Non-integrin membrane-ECM interactions
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
GPVI-mediated activation cascade
Collagen degradation
Collagen degradation
Fibronectin matrix formation
Collagen biosynthesis and modifying enzymes
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Anchoring fibril formation
Crosslinking of collagen fibrils
Syndecan interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
Scavenging by Class A Receptors
GP1b-IX-V activation signalling
Platelet Adhesion to exposed collagen
Platelet Adhesion to exposed collagen
Platelet Aggregation (Plug Formation)
MET activates PTK2 signaling
RUNX2 regulates osteoblast differentiation
Collagen chain trimerization
Enhanced cleavage of VWF variant by ADAMTS13
Enhanced binding of GP1BA variant to VWF multimer:collagen
Defective VWF cleavage by ADAMTS13 variant
Defective VWF binding to collagen type I
Defective binding of VWF variant to GPIb:IX:V
Developmental Lineage of Pancreatic Ductal Cells
Drugs
Pegpleranib
Collagenase clostridium histolyticum
Halofuginone
Clove oil
Vonicog alfa
Von Willebrand factor human
Diseases
Glioma
Malignant pleural mesothelioma
Osteogenesis imperfecta
Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS)
Infantile cortical hyperostosis; Caffey disease
GWAS
Primary biliary cholangitis (
26394269
)
Primary biliary cirrhosis (
22961000
)
Blood cell traits (multivariate analysis) (
31080455
)
Breast cancer (
17903305
)
Heel bone mineral density (
30598549
)
Keratoconus (
33649486
)
Response to taxane treatment (docetaxel) (
23006423
)
Interacting Genes
23 interacting genes:
A2M
ART1
BCCIP
COL1A1
COL1A2
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
FBXO7
HNRNPC
HRAS
HSPG2
LRP1
LYVE1
MDFI
PDAP1
PDGFRA
PDGFRB
PIK3R1
SPARC
THBS1
44 interacting genes:
ATP13A2
BARD1
BGN
BMP1
BRCA1
CAPN1
CD36
CD44
CD93
CDC42
COL18A1
COL7A1
DCN
DDR2
FGF7
FN1
HTRA1
IGFBP3
ITGA2
ITGA5
KEAP1
LAIR1
MAG
MATN2
MCPH1
MMP2
MMP9
NID1
NID2
P4HB
PAK1
PDGFA
PDGFB
PKD1
PRELP
SPARC
TGFBI
TGM2
THBS1
TMPRSS6
TNFAIP3
TXN
UBC
VWF
Entrez ID
5155
1277
HPRD ID
01815
00362
Ensembl ID
ENSG00000100311
ENSG00000108821
Uniprot IDs
A0A384NYY3
P01127
P02452
PDB IDs
1PDG
3MJG
4HQU
4HQX
4QCI
6T9E
1Q7D
2LLP
3EJH
3GXE
5CTD
5CTI
5CVA
5CVB
5K31
5OU8
5OU9
7E7B
7E7D
Enriched GO Terms of Interacting Partners
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Platelet-derived Growth Factor Binding
Extracellular Matrix Structural Constituent Conferring Tensile Strength
Collagen Trimer
Extracellular Matrix
Fibrillar Collagen Trimer
Extracellular Matrix Structural Constituent
Basement Membrane
Anatomical Structure Morphogenesis
Endoplasmic Reticulum Lumen
Collagen Fibril Organization
Developmental Process
Extracellular Matrix Organization
Extracellular Structure Organization
Cellular Response To Amino Acid Stimulus
Phospholipase C Activator Activity
Regulation Of Locomotion
Response To Amino Acid
Enzyme-linked Receptor Protein Signaling Pathway
Animal Organ Morphogenesis
Regulation Of Cell Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Regulation Of Cell Motility
Positive Regulation Of Locomotion
Anatomical Structure Formation Involved In Morphogenesis
Angiogenesis
Extracellular Region
Protease Binding
Proteoglycan Binding
Skin Development
Cell Differentiation
Collagen Type I Trimer
Collagen V Binding
Cellular Developmental Process
Collagen Metabolic Process
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Metanephric Glomerular Capillary Formation
Kinase Regulator Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Extracellular Matrix Assembly
Cell Surface Receptor Signaling Pathway
Response To Wounding
Vascular Endothelial Growth Factor Binding
Basement Membrane Organization
Blood Vessel Morphogenesis
Cartilage Development
Collagen Type XI Trimer
Skeletal System Morphogenesis
Cell Adhesion
Collagen Binding
Extracellular Matrix
Extracellular Region
Extracellular Matrix Structural Constituent
Extracellular Space
Positive Regulation Of Cell Migration
Basement Membrane
Positive Regulation Of Cell Motility
Extracellular Matrix Binding
Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Locomotion
Cell Adhesion
Positive Regulation Of Cell Communication
Positive Regulation Of Signal Transduction
Extracellular Structure Organization
Extracellular Matrix Organization
Regulation Of Cell Migration
Regulation Of Cell Motility
Response To Wounding
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signaling
Regulation Of Locomotion
Developmental Process
Cell-substrate Adhesion
Regulation Of Signal Transduction
Regulation Of Cell Adhesion
Positive Regulation Of Intracellular Signal Transduction
Cell-matrix Adhesion
Platelet Alpha Granule Lumen
Regulation Of Cell Communication
Regulation Of Anatomical Structure Morphogenesis
Regulation Of Cellular Component Organization
Endodermal Cell Differentiation
Regulation Of Smooth Muscle Cell Migration
Positive Regulation Of Cell-substrate Adhesion
Extracellular Exosome
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Regulation Of Cell-substrate Adhesion
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Regulation Of Signaling
Integrin Binding
Regulation Of Developmental Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Adhesion
Cell Surface
Regulation Of MAPK Cascade
Endoplasmic Reticulum Lumen
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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