PDGFB and PDGFRA

Number of citations of the paper that reports this interaction (PMID 2544881)
64

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		PDGFB	PDGFRA
Gene Name		platelet-derived growth factor beta polypeptide	platelet-derived growth factor receptor, alpha polypeptide
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cell Surface Basolateral Plasma Membrane Platelet Alpha Granule Lumen	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet-derived Growth Factor Alpha-receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Vascular Endothelial Growth Factor Binding Protein Homodimerization Activity Platelet-derived Growth Factor Binding
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Platelet Degranulation Positive Regulation Of Glomerular Filtration DNA Replication Protein Phosphorylation Substrate-dependent Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Growth Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Projection Assembly Actin Cytoskeleton Organization Hemopoiesis Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Response To Estradiol Response To Insulin Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Paracrine Signaling Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle, Embryonic Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Chemotaxis Cell Chemotaxis Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Endothelium Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration	Luteinization In Utero Embryonic Development Cell Activation Hematopoietic Progenitor Cell Differentiation Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Estrogen Metabolic Process Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Platelet Activation Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Peptidyl-tyrosine Phosphorylation Signal Transduction Involved In Regulation Of Gene Expression Extracellular Matrix Organization Lung Development Adrenal Gland Development Positive Regulation Of Cell Migration Male Genitalia Development Leydig Cell Differentiation Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Wound Healing Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of DNA Replication Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Embryonic Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Embryonic Skeletal System Morphogenesis Regulation Of Chemotaxis Cardiac Myofibril Assembly Palate Development Face Morphogenesis Cell Chemotaxis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Cellular Response To Amino Acid Stimulus Metanephric Glomerular Capillary Formation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Mesenchymal Stem Cell Differentiation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Response to elevated platelet cytosolic Ca2+ Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs			Becaplermin Imatinib Sunitinib Pazopanib Regorafenib Ponatinib
Diseases
GWAS			Corneal astigmatism ( 22144915) Corneal curvature ( 23401653 21665993) Height ( 18193045) Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978) Red blood cell count ( 20139978)
Protein-Protein Interactions		20 interactors: A2M ART1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB SPARC THBS1	31 interactors: CAV1 CAV3 CBL CCDC155 CRK CRKL FBXO25 GRB14 ITGAV ITGB3 JAK1 PDGFA PDGFB PDGFC PDGFRB PIK3R1 PLCG1 PTPN11 SHB SHF SLC9A3R1 SNX2 SNX4 SNX6 SRPK1 STAT1 STAT3 STAT5A STAT5B TGFBR2 ULBP2
Entrez ID		5155	5156
HPRD ID		01815	01429
Ensembl ID		ENSG00000100311	ENSG00000134853
Uniprot IDs		P01127	P16234
PDB IDs		1PDG 3MJG 4HQU 4HQX	1GQ5
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cardiovascular System Development Multicellular Organismal Metabolic Process Response To Wounding Blood Vessel Development Vasculature Development Skeletal System Development Cellular Response To Amino Acid Stimulus Anatomical Structure Morphogenesis Wound Healing Organ Morphogenesis Response To External Stimulus Platelet Activation Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Response To Amino Acid Developmental Process Response To Growth Factor Locomotion Blood Coagulation Hemostasis Skeletal System Morphogenesis Collagen Fibril Organization Heart Development Cellular Response To Acid Chemical Regulation Of Body Fluid Levels Regulation Of Cell Migration Chemotaxis Anatomical Structure Development Regulation Of Cell Motility Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Stimulus Tissue Development System Development Endocytosis Blood Vessel Morphogenesis Connective Tissue Development Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Organic Substance Organ Development Cellular Response To Organonitrogen Compound Ossification Protein Heterotrimerization Cellular Response To Stimulus	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Wound Healing Regulation Of Signaling Regulation Of Signal Transduction Immune System Process Regulation Of Cellular Component Movement Response To Wounding Regulation Of Body Fluid Levels Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Response To Growth Factor Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Response To Stress Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Regulation Of Phosphorus Metabolic Process Blood Coagulation Positive Regulation Of Protein Metabolic Process Hemostasis Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Protein Metabolic Process Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune System Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Immune Response Positive Regulation Of Cellular Component Movement Leukocyte Migration Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Protein Phosphorylation Response To Hormone Positive Regulation Of Transferase Activity Epidermal Growth Factor Receptor Signaling Pathway Response To Organic Substance Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration
Tagcloud ?		5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded	address alteration amplifications anaplastic confirms copy devising gbm gbms glial glioblastomas gliomas heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
Tagcloud (Difference) ?		5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioma grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded	address alteration amplifications anaplastic confirms copy devising gbm gbms glial heterogeneity intratumoral inversion investigating kit measuring mutational oligodendroglioma personalized point probes rb1 regional spatially surveyed tp53 underscore
Tagcloud (Intersection) ?		glioblastomas gliomas