PDGFB and HNRNPC

Number of citations of the paper that reports this interaction (PubMedID 10409733)
60

Data Source:
HPRD (in vitro)

		PDGFB	HNRNPC
Description		platelet derived growth factor subunit B	heterogeneous nuclear ribonucleoprotein C
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cell Surface Membrane Basolateral Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Platelet-derived Growth Factor Complex	Chromatin Extracellular Region Nucleus Nucleoplasm Spliceosomal Complex Telomerase Holoenzyme Complex Cytosol Actin Cytoskeleton Membrane Protein-containing Complex Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Platelet-derived Growth Factor Binding	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(U) RNA Binding Nucleosomal DNA Binding Identical Protein Binding Telomerase RNA Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	Angiogenesis Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Positive Regulation Of Glomerular Filtration Protein Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Heart Development Positive Regulation Of Cell Population Proliferation Response To Wounding Gene Expression Regulation Of Gene Expression Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Smooth Muscle Adaptation Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-tyrosine Phosphorylation Hemopoiesis Positive Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Intracellular Signal Transduction Interleukin-18-mediated Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Paracrine Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Division Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Chemotaxis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of MiRNA Transcription Positive Regulation Of MiRNA Transcription Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration	MRNA Splicing, Via Spliceosome Osteoblast Differentiation Chromatin Remodeling MRNA Processing RNA Splicing Negative Regulation Of Telomere Maintenance Via Telomerase 3'-UTR-mediated MRNA Stabilization
Pathways		Platelet degranulation PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer Non-integrin membrane-ECM interactions RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
Drugs		Pegpleranib
Diseases		Glioma Malignant pleural mesothelioma
GWAS		Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000)	Bipolar disorder ( 21738484 31043756) Height ( 31562340)
Interacting Genes		23 interacting genes: A2M ART1 BCCIP COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 FBXO7 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB PIK3R1 SPARC THBS1	59 interacting genes: AP1M1 BARD1 BRCA1 BRCA2 BRIP1 CCDC85B CDKN2A CSNK1A1 CSNK2A1 CSNK2A2 DHX9 DISC1 DLG4 EPS8 ERG ESR1 FAS FXR2 GRB2 IL7R KHDRBS3 KPNA2 KPNA3 KPNA4 KPNA5 KRAS LMO2 LMO3 MAPT MEOX2 NUFIP2 OGT PALB2 PAX6 PDGFB PHKB PIN1 PJA1 PRKDC PTBP2 RAD51 RALYL RBM41 RBPMS2 SDCBP SF3B2 SMARCD1 SREK1 SRPK2 SUMO1 SUMO1P1 TRAF3 UBE2I USP7 WEE2-AS1 YWHAE YWHAQ ZFYVE26 ZNF581
Entrez ID		5155	3183
HPRD ID		01815	01243
Ensembl ID		ENSG00000100311	ENSG00000092199
Uniprot IDs		A0A384NYY3 P01127	P07910
PDB IDs		1PDG 3MJG 4HQU 4HQX 4QCI 6T9E	1TXP 1WF2 2MXY 2MZ1 3LN4
Enriched GO Terms of Interacting Partners?		Platelet-derived Growth Factor Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Collagen Trimer Extracellular Matrix Fibrillar Collagen Trimer Extracellular Matrix Structural Constituent Basement Membrane Anatomical Structure Morphogenesis Endoplasmic Reticulum Lumen Collagen Fibril Organization Developmental Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Amino Acid Stimulus Phospholipase C Activator Activity Regulation Of Locomotion Response To Amino Acid Enzyme-linked Receptor Protein Signaling Pathway Animal Organ Morphogenesis Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Motility Positive Regulation Of Locomotion Anatomical Structure Formation Involved In Morphogenesis Angiogenesis Extracellular Region Protease Binding Proteoglycan Binding Skin Development Cell Differentiation Collagen Type I Trimer Collagen V Binding Cellular Developmental Process Collagen Metabolic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Metanephric Glomerular Capillary Formation Kinase Regulator Activity Positive Regulation Of Smooth Muscle Cell Proliferation Extracellular Matrix Assembly Cell Surface Receptor Signaling Pathway Response To Wounding Vascular Endothelial Growth Factor Binding Basement Membrane Organization Blood Vessel Morphogenesis Cartilage Development Collagen Type XI Trimer Skeletal System Morphogenesis Cell Adhesion	Nuclear Ubiquitin Ligase Complex Nucleus Macromolecule Metabolic Process RNA Binding Nucleic Acid Metabolic Process Protein Localization To Organelle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of RNA Metabolic Process NLS-dependent Protein Nuclear Import Complex Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Regulation Of Cell Communication Regulation Of Signaling BRCA1-B Complex DNA Metabolic Process DNA Repair DNA Recombination Regulation Of Ubiquitin-dependent Protein Catabolic Process Identical Protein Binding Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of Cell Cycle Nuclear Body Organization Double-strand Break Repair Via Homologous Recombination Regulation Of Macromolecule Biosynthetic Process Recombinational Repair Nuclear Import Signal Receptor Activity Cytosol Regulation Of DNA Metabolic Process Nuclear Localization Sequence Binding Regulation Of Cell Cycle Process Regulation Of DNA Damage Checkpoint Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus Regulation Of Cellular Response To Stress Cellular Component Assembly PML Body Cytoplasm Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus
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