PDGFB and HRAS

Number of citations of the paper that reports this interaction (PMID 10485711)
289

Data Source:
HPRD (in vitro)

		PDGFB	HRAS
Gene Name		platelet-derived growth factor beta polypeptide	Harvey rat sarcoma viral oncogene homolog
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cell Surface Basolateral Plasma Membrane Platelet Alpha Granule Lumen	Golgi Membrane Nucleus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding	Protein Binding GTP Binding Protein C-terminus Binding
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Platelet Degranulation Positive Regulation Of Glomerular Filtration DNA Replication Protein Phosphorylation Substrate-dependent Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Growth Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Projection Assembly Actin Cytoskeleton Organization Hemopoiesis Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Response To Estradiol Response To Insulin Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Paracrine Signaling Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle, Embryonic Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Chemotaxis Cell Chemotaxis Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Endothelium Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration	MAPK Cascade Activation Of MAPKK Activity Positive Regulation Of Protein Phosphorylation Endocytosis Chemotaxis Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Signal Transduction Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Visual Learning Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Negative Regulation Of Gene Expression Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Rac GTPase Activity Negative Regulation Of Rho GTPase Activity Positive Regulation Of Rac Protein Signal Transduction Social Behavior Fc-epsilon Receptor Signaling Pathway Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Negative Regulation Of Cell Differentiation Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Epithelial Cell Proliferation Leukocyte Migration Striated Muscle Cell Differentiation Protein Heterooligomerization Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Wound Healing Cellular Senescence Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Ruffle Assembly Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of MiRNA Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Response to elevated platelet cytosolic Ca2+ Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Signaling by FGFR in disease SHC-mediated cascade MEK activation FCERI mediated MAPK activation CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Interleukin receptor SHC signaling Gastrin-CREB signalling pathway via PKC and MAPK p38MAPK events EPH-Ephrin signaling SOS-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Signalling to RAS Downstream signal transduction Signaling by FGFR mutants Signaling by EGFR in Cancer Fc epsilon receptor (FCERI) signaling Interleukin-2 signaling Interleukin-3, 5 and GM-CSF signaling Frs2-mediated activation Transmission across Chemical Synapses Ras activation uopn Ca2+ infux through NMDA receptor Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway EPHB-mediated forward signaling IRS-related events triggered by IGF1R EGFR Transactivation by Gastrin VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling Activation of NMDA receptor upon glutamate binding and postsynaptic events RAF phosphorylates MEK Downstream signaling of activated FGFR NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Post NMDA receptor activation events Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR ARMS-mediated activation SHC1 events in EGFR signaling RAF activation IRS-mediated signalling FRS2-mediated cascade Activation of RAS in B cells Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Interleukin receptor SHC signaling Constitutive Signaling by EGFRvIII
Drugs			Hexane-1,6-Diol Trifluoroethanol Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate N,N\'-DIMETHYL-N-(ACETYL)-N\'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE
Diseases
GWAS
Protein-Protein Interactions		20 interactors: A2M ART1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB SPARC THBS1	78 interactors: AGTR1 ARAF ARHGEF1 BCL2 BRAF BRAP CAV1 CDC25A CDC25C DEAF1 DGKZ FNTA FNTB FYN GPSM2 GRB2 GRIN1 GRIN2D ICMT IKZF3 IL3 INSR IRAK1 IRAK2 ITSN1 KRT18 LGALS1 MAP2K1 MAPK8 MLLT4 NF1 PDE6D PDGFB PIK3CA PIK3CD PIK3CG PIK3R1 PLCE1 PRKCI PRKCZ RABAC1 RABGEF1 RAF1 RALA RALGDS RAP1B RAP1GDS1 RAPGEF1 RARRES3 RASA1 RASGRF1 RASGRP1 RASGRP4 RASIP1 RASSF1 RASSF2 RASSF5 RGL1 RGL2 RGL4 RGS12 RHOD RIN1 RIT2 RNF115 SHOC2 SNRPE SNX17 SOS1 SOS2 SRC TIAM1 TLR2 TLR9 TP73 TTC1 VAV1 ZBTB12
Entrez ID		5155	3265
HPRD ID		01815	01813
Ensembl ID		ENSG00000100311	ENSG00000174775
Uniprot IDs		P01127	P01112
PDB IDs		1PDG 3MJG 4HQU 4HQX	121P 1AA9 1AGP 1BKD 1CLU 1CRP 1CRQ 1CRR 1CTQ 1GNP 1GNQ 1GNR 1HE8 1IAQ 1IOZ 1JAH 1JAI 1K8R 1LF0 1LF5 1LFD 1NVU 1NVV 1NVW 1NVX 1P2S 1P2T 1P2U 1P2V 1PLJ 1PLK 1PLL 1Q21 1QRA 1RVD 1WQ1 1XCM 1XD2 1XJ0 1ZVQ 1ZW6 221P 2C5L 2CE2 2CL0 2CL6 2CL7 2CLC 2CLD 2EVW 2GDP 2LCF 2LWI 2Q21 2QUZ 2RGA 2RGB 2RGC 2RGD 2RGE 2RGG 2UZI 2VH5 2X1V 3DDC 3I3S 3K8Y 3K9L 3K9N 3KKM 3KKN 3KUD 3L8Y 3L8Z 3LBH 3LBI 3LBN 3LO5 3OIU 3OIV 3OIW 3RRY 3RRZ 3RS0 3RS2 3RS3 3RS4 3RS5 3RS7 3RSL 3RSO 3TGP 421P 4DLR 4DLS 4DLT 4DLU 4DLV 4DLW 4DLX 4DLY 4DLZ 4DST 4DSU 4EFL 4EFM 4EFN 4G0N 4G3X 4K81 4Q21 521P 5P21 621P 6Q21 721P 821P
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cardiovascular System Development Multicellular Organismal Metabolic Process Response To Wounding Blood Vessel Development Vasculature Development Skeletal System Development Cellular Response To Amino Acid Stimulus Anatomical Structure Morphogenesis Wound Healing Organ Morphogenesis Response To External Stimulus Platelet Activation Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Response To Amino Acid Developmental Process Response To Growth Factor Locomotion Blood Coagulation Hemostasis Skeletal System Morphogenesis Collagen Fibril Organization Heart Development Cellular Response To Acid Chemical Regulation Of Body Fluid Levels Regulation Of Cell Migration Chemotaxis Anatomical Structure Development Regulation Of Cell Motility Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Stimulus Tissue Development System Development Endocytosis Blood Vessel Morphogenesis Connective Tissue Development Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Organic Substance Organ Development Cellular Response To Organonitrogen Compound Ossification Protein Heterotrimerization Cellular Response To Stimulus	Intracellular Signal Transduction Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Signal Transduction Positive Regulation Of Catalytic Activity Neurotrophin TRK Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Small GTPase Mediated Signal Transduction Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Metabolic Process Cellular Response To Stimulus Ras Protein Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Ras Protein Signal Transduction Positive Regulation Of Hydrolase Activity Positive Regulation Of Signal Transduction Regulation Of Metabolic Process Cellular Response To Organic Substance Regulation Of GTPase Activity Regulation Of Cellular Process Positive Regulation Of GTPase Activity Response To Organic Substance Positive Regulation Of Ras GTPase Activity Regulation Of Ras GTPase Activity Regulation Of Phosphorylation Platelet Activation Response To Wounding Positive Regulation Of Protein Modification Process Epidermal Growth Factor Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Immune System Process Cell Activation Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus
Tagcloud ?		5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded	12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated
Tagcloud (Difference) ?		5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded	12th arising arose carcinogenic carrying clustered codon contain detectable epithelium find fraction gaa gga gland indirectly mammary measure methylurea mutants nitroso nmu organ origin preexisting sectors transition untreated
Tagcloud (Intersection) ?