PDGFB and ART1

Number of citations of the paper that reports this interaction (PMID 11498506)
3

Data Source:
HPRD (in vitro)

		PDGFB	ART1
Gene Name		platelet-derived growth factor beta polypeptide	ADP-ribosyltransferase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Cell Surface Basolateral Plasma Membrane Platelet Alpha Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Anchored Component Of Membrane Sarcoplasmic Reticulum Membrane
	Molecular Function	Platelet-derived Growth Factor Receptor Binding Protein Binding Collagen Binding Growth Factor Activity Superoxide-generating NADPH Oxidase Activator Activity Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Platelet-derived Growth Factor Binding	NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity
	Biological Process	Response To Hypoxia Embryonic Placenta Development Positive Regulation Of Endothelial Cell Proliferation Monocyte Chemotaxis Platelet Degranulation Positive Regulation Of Glomerular Filtration DNA Replication Protein Phosphorylation Substrate-dependent Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Response To Wounding Negative Regulation Of Phosphatidylinositol Biosynthetic Process Negative Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Growth Peptidyl-serine Phosphorylation Peptidyl-tyrosine Phosphorylation Cell Projection Assembly Actin Cytoskeleton Organization Hemopoiesis Platelet Activation Extracellular Matrix Organization Positive Regulation Of Cell Migration Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Response To Estradiol Response To Insulin Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Paracrine Signaling Fc-epsilon Receptor Signaling Pathway Response To Drug Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Cell Cycle, Embryonic Platelet-derived Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Blood Vessel Morphogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Chemotaxis Cell Chemotaxis Branching Involved In Salivary Gland Morphogenesis Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Mycophenolic Acid Positive Regulation Of Glomerular Mesangial Cell Proliferation Metanephric Glomerular Mesangial Cell Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Endothelium Development Reactive Oxygen Species Metabolic Process Positive Regulation Of Calcium Ion Import Positive Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of Metanephric Mesenchymal Cell Migration	Protein ADP-ribosylation Innate Immune Response
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Response to elevated platelet cytosolic Ca2+ Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Adaptive Immune System	Alpha-defensins Defensins Innate Immune System
Drugs			5-Bromonicotinamide Nicotinamide-Adenine-Dinucleotide
Diseases
GWAS
Protein-Protein Interactions		20 interactors: A2M ART1 COL1A1 COL1A2 COL2A1 COL3A1 COL4A1 COL5A1 COL6A1 HNRNPC HRAS HSPG2 LRP1 LYVE1 MDFI PDAP1 PDGFRA PDGFRB SPARC THBS1	1 interactors: PDGFB
Entrez ID		5155	417
HPRD ID		01815	03377
Ensembl ID		ENSG00000100311	ENSG00000129744
Uniprot IDs		P01127	P52961
PDB IDs		1PDG 3MJG 4HQU 4HQX
Enriched GO Terms of Interacting Partners?		Extracellular Matrix Organization Extracellular Structure Organization Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Cardiovascular System Development Multicellular Organismal Metabolic Process Response To Wounding Blood Vessel Development Vasculature Development Skeletal System Development Cellular Response To Amino Acid Stimulus Anatomical Structure Morphogenesis Wound Healing Organ Morphogenesis Response To External Stimulus Platelet Activation Movement Of Cell Or Subcellular Component Cellular Response To Growth Factor Stimulus Response To Amino Acid Developmental Process Response To Growth Factor Locomotion Blood Coagulation Hemostasis Skeletal System Morphogenesis Collagen Fibril Organization Heart Development Cellular Response To Acid Chemical Regulation Of Body Fluid Levels Regulation Of Cell Migration Chemotaxis Anatomical Structure Development Regulation Of Cell Motility Cartilage Development Involved In Endochondral Bone Morphogenesis Response To Stimulus Tissue Development System Development Endocytosis Blood Vessel Morphogenesis Connective Tissue Development Regulation Of Locomotion Regulation Of Cellular Component Movement Cellular Response To Organic Substance Organ Development Cellular Response To Organonitrogen Compound Ossification Protein Heterotrimerization Cellular Response To Stimulus	Metanephric Glomerular Mesangial Cell Development Metanephric Glomerular Endothelium Development Paracrine Signaling Cellular Response To Mycophenolic Acid Metanephric Glomerular Mesangial Cell Differentiation Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Positive Regulation Of Mitotic Cell Cycle, Embryonic Negative Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Hyaluronan Biosynthetic Process Glomerular Mesangial Cell Proliferation Positive Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Glomerular Mesangial Cell Development Negative Regulation Of Phospholipid Biosynthetic Process Glomerular Endothelium Development Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Glomerular Filtration Positive Regulation Of Glomerular Mesangial Cell Proliferation Mesangial Cell Development Platelet-derived Growth Factor Receptor-beta Signaling Pathway Renal Interstitial Fibroblast Development Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerulus Development Cell Proliferation Involved In Metanephros Development Metanephric Glomerulus Vasculature Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Differentiation Involved In Metanephros Development Regulation Of Glomerular Filtration Cell Proliferation Involved In Kidney Development Positive Regulation Of Calcium Ion Import Monocyte Chemotaxis Metanephric Glomerulus Development Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Platelet Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of DNA Biosynthetic Process Glomerulus Vasculature Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Calcium Ion Import Positive Regulation Of Smooth Muscle Cell Migration Metanephric Epithelium Development Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Chemotaxis Activation Of Protein Kinase B Activity Branching Involved In Salivary Gland Morphogenesis Regulation Of Protein Autophosphorylation Positive Regulation Of Embryonic Development Regulation Of Platelet Activation
Tagcloud ?		5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded	adaptor any1 arn1 arrestin canavanine cat1 cerevisiae confers correctively endocytosis governs homologous hypersensitivity pombe pub1 py saccharomyces schizosaccharomyces suppresses transporters tsc1 tsc2 tsc2delta tuberous ubiquitinated ubiquitinations undergoes uptake
Tagcloud (Difference) ?		5b alone angiogenesis associates aurora coexpression dataset ectopic effector glioblastomas glioma gliomas grade isoform latent mesenchymal modeled pn predominantly promoters proneural reveals shorter stat5 stat5b tcga transducer xl yielded	adaptor any1 arn1 arrestin canavanine cat1 cerevisiae confers correctively endocytosis governs homologous hypersensitivity pombe pub1 py saccharomyces schizosaccharomyces suppresses transporters tsc1 tsc2 tsc2delta tuberous ubiquitinated ubiquitinations undergoes uptake
Tagcloud (Intersection) ?