SCLY and LNX2

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid)

		SCLY	LNX2
Description		selenocysteine lyase	ligand of numb-protein X 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Catalytic Complex	Plasma Membrane
	Molecular Function	Protein Binding Selenocysteine Lyase Activity Amino Acid Binding Transferase Activity Lyase Activity Protein Homodimerization Activity Vitamin B6 Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Amino Acid Metabolic Process Selenocysteine Catabolic Process	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se
Drugs		Pyridoxal phosphate Pyridoxal phosphate
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		5 interacting genes: CREB3 LNX2 OGT SEPHS2 TERF2IP	90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581
Entrez ID		51540	222484
HPRD ID		15303	10042
Ensembl ID		ENSG00000132330	ENSG00000139517
Uniprot IDs		A0A0A0MQU4 B4DDP9 Q59FK2 Q96I15	Q8N448
PDB IDs		3GZC 3GZD	2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT
Enriched GO Terms of Interacting Partners?		Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Selenocysteine Biosynthetic Process Selenide, Water Dikinase Activity Selenium Compound Metabolic Process Negative Regulation Of DNA Recombination At Telomere Protein O-acetylglucosaminyltransferase Activity Selenocysteine Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose CCR1 Chemokine Receptor Binding Release From Viral Latency Protection From Non-homologous End Joining At Telomere Shelterin Complex Regulation Of Transcription By Glucose Nuclear Telomere Cap Complex CAMP Response Element Binding Protein Binding G-rich Strand Telomeric DNA Binding NSL Complex Protein Localization To Chromosome, Telomeric Region	Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?