SCLY and SEPHS2

Number of citations of the paper that reports this interaction (PubMedID 39547224)
0

Data Source:
BioGRID (pull down)

		SCLY	SEPHS2
Description		selenocysteine lyase	selenophosphate synthetase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Catalytic Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Selenocysteine Lyase Activity Amino Acid Binding Transferase Activity Lyase Activity Protein Homodimerization Activity Vitamin B6 Binding	Nucleotide Binding Selenide, Water Dikinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Amino Acid Metabolic Process Selenocysteine Catabolic Process	Selenium Compound Metabolic Process Selenocysteine Metabolic Process Selenocysteine Biosynthetic Process
Pathways		Metabolism of ingested SeMet, Sec, MeSec into H2Se	Selenocysteine synthesis
Drugs		Pyridoxal phosphate Pyridoxal phosphate
Diseases
GWAS			Eosinophil count ( 32888494)
Interacting Genes		5 interacting genes: CREB3 LNX2 OGT SEPHS2 TERF2IP	3 interacting genes: ARHGEF5 PRDX6 SCLY
Entrez ID		51540	22928
HPRD ID		15303	12096
Ensembl ID		ENSG00000132330	ENSG00000179918
Uniprot IDs		A0A0A0MQU4 B4DDP9 Q59FK2 Q96I15	Q99611
PDB IDs		3GZC 3GZD
Enriched GO Terms of Interacting Partners?		Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Deacetylase Activity Selenocysteine Biosynthetic Process Selenide, Water Dikinase Activity Selenium Compound Metabolic Process Negative Regulation Of DNA Recombination At Telomere Protein O-acetylglucosaminyltransferase Activity Selenocysteine Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose CCR1 Chemokine Receptor Binding Release From Viral Latency Protection From Non-homologous End Joining At Telomere Shelterin Complex Regulation Of Transcription By Glucose Nuclear Telomere Cap Complex CAMP Response Element Binding Protein Binding G-rich Strand Telomeric DNA Binding NSL Complex Protein Localization To Chromosome, Telomeric Region	Selenocysteine Lyase Activity Vitamin B6 Binding Selenocysteine Catabolic Process Positive Regulation Of Protein Import Myeloid Dendritic Cell Chemotaxis Regulation Of Protein Import Selenocysteine Metabolic Process 1-acylglycerophosphocholine O-acyltransferase Activity Peroxiredoxin Activity Calcium-independent Phospholipase A2 Activity Positive Regulation Of Podosome Assembly Regulation Of Podosome Assembly Positive Regulation Of JUN Kinase Activity Amino Acid Binding Dendritic Cell Migration Hematopoietic Stem Cell Homeostasis Dendritic Cell Chemotaxis Glutathione Peroxidase Activity Phospholipase A2 Activity Hydrogen Peroxide Catabolic Process Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Glycerophospholipid Catabolic Process Serine Family Amino Acid Metabolic Process Catalytic Complex Positive Regulation Of MAP Kinase Activity Podosome Phospholipid Catabolic Process Positive Regulation Of RNA Splicing Cell Redox Homeostasis
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