PDE9A and ERCC1

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		PDE9A	ERCC1
Name		phosphodiesterase 9A	ERCC excision repair 1, endonuclease non-catalytic subunit
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Sarcolemma Cell Projection Perikaryon Perinuclear Region Of Cytoplasm	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP Metabolic Process CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neural Precursor Cell Proliferation	Pyrimidine Dimer Repair By Nucleotide-excision Repair Telomere Maintenance DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation DNA Damage Response Response To Oxidative Stress Germ Cell Development Spermatogenesis Cell Population Proliferation Determination Of Adult Lifespan Male Gonad Development UV Protection Response To X-ray Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Insulin-like Growth Factor Receptor Signaling Pathway Cell Development Oogenesis Chromosome Organization Positive Regulation Of Transcription Initiation By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Pathways		cGMP effects	HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil	None
Diseases		None	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Perceived unattractiveness to mosquitoes ( 28199695 )	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Simvastatin-induced myopathy ( 31220337 )
Novel Interactors		3 novel interactors: ERG MX1 PCNT	1 novel interactors: ZCCHC2
Interacting Genes		43 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERCC1 FXR1 FXR2 GORASP2 HERC2 HIPK1 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SNRNP70 SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5 ZMYM5	19 interacting genes: APP CHRM5 DRC4 ERCC4 KIF11 MKRN3 PDE9A RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA
Entrez ID		5152	2067
HPRD ID		09115	00533
Ensembl ID		ENSG00000160191	ENSG00000012061
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	P07992
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ 7F0I 8BPY	1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytosol Identical Protein Binding Aggresome Assembly Cytosolic Ciliogenesis Protein Binding Pyrimidine Dimer Repair Positive Regulation Of Long-term Neuronal Synaptic Plasticity Inclusion Body Assembly	Nucleotide-excision Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Replication Factor A Complex DNA Repair Double-strand Break Repair DNA Recombination Damaged DNA Binding DNA Metabolic Process Telomere Maintenance DNA Damage Response Base-excision Repair Single-stranded DNA Binding Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Chromosome Organization Nucleotide-excision Repair Factor 1 Complex Mismatch Repair Cellular Response To Stress Nucleic Acid Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleobase-containing Compound Metabolic Process G-rich Strand Telomeric DNA Binding UV Protection Macromolecule Metabolic Process Organelle Organization Mitotic Recombination Site Of Double-strand Break Response To Stress Positive Regulation Of Long-term Synaptic Potentiation DNA Double-strand Break Processing Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening DNA Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Telomere Maintenance Chromosome, Telomeric Region Double-strand Break Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Damage Recognition Histone H3 Ubiquitin Ligase Activity RRNA (uridine-C5-)-methyltransferase Activity Mitotic Spindle Assembly Regulation Of CAMP/PKA Signal Transduction DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening