PDE9A and HERC2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PDE9A	HERC2
Description		phosphodiesterase 9A	HECT and RLD domain containing E3 ubiquitin protein ligase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Sarcolemma Cell Projection Perikaryon Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Centriole Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Ubiquitin-protein Transferase Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding SUMO Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP Metabolic Process CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neural Precursor Cell Proliferation	DNA Repair Intracellular Protein Transport DNA Damage Response Spermatogenesis Protein Ubiquitination Neuron Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Notch Signaling Pathway
Pathways		cGMP effects	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Perceived unattractiveness to mosquitoes ( 28199695)	Adiponectin levels ( 33562295) Age-related macular degeneration ( 32741009) Asthma and eczema ( 34155719) Basal cell carcinoma ( 31174203) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Bone mineral content ( 31790847) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Colorectal cancer ( 29228715) Corneal astigmatism ( 30306274) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Diisocyanate-induced asthma ( 25918132) Eye color ( 23548203 30664655 23118974) Eye color (brightness) ( 30664655) Eye color (hue) ( 30664655) Eye color (saturation) ( 30664655) Eye color traits ( 20463881 30166351) Hair color ( 26926045 29662168 23548203 30664655) Hair morphology traits ( 30166351) Intraocular pressure ( 31959993) Iris color ( 18252221) Iris color (b* coordinate) ( 30895295) Iris color (L* coordinate) ( 30895295) Iris heterochromicity ( 30895295) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Low tan response ( 29739929) Monobrow ( 27182965) Nevus count or cutaneous melanoma ( 32341527) Perceived skin darkness ( 25963972) Red vs. brown/black hair color ( 30531825) Refractive astigmatism ( 30306274) Rosacea symptom severity ( 29771307) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655 31315583) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin pigmentation traits ( 30166351) Skin sensitivity to sun ( 25963972) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 31174203 26829030) Tanning ( 23548203) Type 2 diabetes ( 32499647) Uveal melanoma ( 28781888) Vitiligo ( 22561518 27723757)
Interacting Genes		43 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERCC1 FXR1 FXR2 GORASP2 HERC2 HIPK1 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SNRNP70 SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5 ZMYM5	15 interacting genes: BDKRB2 C5AR2 CALM1 CDC42 ERG PDE9A RNF11 STK11 TTC3 UBE2D1 UBE2D2 UBE2D3 UBE2L3 UBE2N XPA
Entrez ID		5152	8924
HPRD ID		09115	06905
Ensembl ID		ENSG00000160191	ENSG00000128731
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	A8KAQ8 O95714
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ 7F0I 8BPY	2KEO 3KCI 4L1M 6WW3 6WW4 7Q40 7Q41 7Q42 7Q43 7Q44 7Q45 7Q46 7RGW
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytosol Identical Protein Binding Aggresome Assembly Cytosolic Ciliogenesis Protein Binding Pyrimidine Dimer Repair Positive Regulation Of Long-term Neuronal Synaptic Plasticity Inclusion Body Assembly	Ubiquitin Conjugating Enzyme Activity Ubiquitin-protein Transferase Activity Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Modification Process Protein K48-linked Ubiquitination Post-translational Protein Modification Catabolic Process Macromolecule Catabolic Process Negative Regulation Of TORC1 Signaling Ubiquitin-protein Transferase Activator Activity Proteolysis Protein Autoubiquitination Nucleoplasm Golgi Localization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Cytosol Positive Regulation Of Post-translational Protein Modification Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of TOR Signaling Regulation Of Protein Polyubiquitination Nucleotide Binding Transferase Activity Negative Regulation Of Intracellular Signal Transduction Protein-containing Complex Positive Regulation Of Protein Targeting To Mitochondrion Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein K11-linked Ubiquitination Regulation Of Protein Ubiquitination Substantia Nigra Development Regulation Of Protein Targeting To Mitochondrion ATP Binding Signal Transduction Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Nucleotide-excision Repair, DNA Damage Recognition
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