PDE9A and PHYHIPL

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		PDE9A	PHYHIPL
Description		phosphodiesterase 9A	phytanoyl-CoA 2-hydroxylase interacting protein like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Sarcolemma Cell Projection Perikaryon Perinuclear Region Of Cytoplasm	Cytoplasm
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP Metabolic Process CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		cGMP effects
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Perceived unattractiveness to mosquitoes ( 28199695)	Daytime sleep phenotypes ( 27126917) Night sleep phenotypes ( 27126917)
Interacting Genes		43 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERCC1 FXR1 FXR2 GORASP2 HERC2 HIPK1 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SNRNP70 SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5 ZMYM5	4 interacting genes: ERRFI1 HSPB1 MEI4 PDE9A
Entrez ID		5152	84457
HPRD ID		09115	15131
Ensembl ID		ENSG00000160191	ENSG00000165443
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	Q96FC7
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ 7F0I 8BPY
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytosol Identical Protein Binding Aggresome Assembly Cytosolic Ciliogenesis Protein Binding Pyrimidine Dimer Repair Positive Regulation Of Long-term Neuronal Synaptic Plasticity Inclusion Body Assembly	Regulation Of Interleukin-1 Production Negative Regulation Of Protein Kinase C Signaling Regulation Of Interleukin-1 Beta Production Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Intracellular Signal Transduction Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Regulation Of Tumor Necrosis Factor Production Protein Kinase C Inhibitor Activity Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Cellular Response To Growth Factor Stimulus Regulation Of Protein Kinase C Signaling Negative Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Chemotaxis Regulation Of Protein Phosphorylation Protein Transport Along Microtubule Response To Growth Factor Negative Regulation Of Cell Communication Anterograde Axonal Protein Transport Contractile Muscle Fiber Negative Regulation Of Signaling Cyclic Nucleotide Catabolic Process CGMP Catabolic Process Regulation Of Muscle System Process Chondrocyte Proliferation Skin Morphogenesis Negative Regulation Of Signaling Receptor Activity Lung Vasculature Development Limb Joint Morphogenesis Fat Pad Development Progesterone Receptor Signaling Pathway Regulation Of Type B Pancreatic Cell Proliferation Lung Epithelium Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Protein Tyrosine Kinase Activity Regulation Of Protein Autophosphorylation Meiotic DNA Double-strand Break Formation Lateral Element Regulation Of Phosphorylation Negative Regulation Of Collagen Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Binding Cellular Hyperosmotic Response 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP Metabolic Process Negative Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cardiac Muscle Hypertrophy In Response To Stress 3',5'-cyclic-GMP Phosphodiesterase Activity
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