PDE9A and TRPV6

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PDE9A	TRPV6
Description		phosphodiesterase 9A	transient receptor potential cation channel subfamily V member 6
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Sarcolemma Cell Projection Perikaryon Perinuclear Region Of Cytoplasm	Plasma Membrane Membrane Calcium Channel Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Calmodulin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP Metabolic Process CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neural Precursor Cell Proliferation	Monoatomic Ion Transport Calcium Ion Transport Regulation Of Calcium Ion-dependent Exocytosis Monoatomic Ion Transmembrane Transport Parathyroid Hormone Secretion Response To Calcium Ion Calcium Ion Homeostasis Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane
Pathways		cGMP effects	TRP channels
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Perceived unattractiveness to mosquitoes ( 28199695)	Alcoholic chronic pancreatitis ( 28754779) Anxiety ( 31906708) Cancer ( 29299148) Mastocytosis ( 32752121)
Interacting Genes		43 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERCC1 FXR1 FXR2 GORASP2 HERC2 HIPK1 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SNRNP70 SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5 ZMYM5	17 interacting genes: CALB1 CALM1 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-8 MDFI MID2 NEDD4 NOTCH2NLA PDE9A PNMA1 PRKCA PTPN1 S100A10 SNCA TRAF1
Entrez ID		5152	55503
HPRD ID		09115	05982
Ensembl ID		ENSG00000160191	ENSG00000165125
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	Q9H1D0
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ 7F0I 8BPY	6BO8 6BO9 6BOA 6D7S 6D7T 6E2F 7K4A 7K4B 7K4C 7K4D 7K4E 7K4F 7S88 7S89 7S8B 7S8C 8FOA 8FOB 8SP8 9CUH 9CUI 9CUJ 9CUK
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytosol Identical Protein Binding Aggresome Assembly Cytosolic Ciliogenesis Protein Binding Pyrimidine Dimer Repair Positive Regulation Of Long-term Neuronal Synaptic Plasticity Inclusion Body Assembly	Keratin Filament Intermediate Filament Regulation Of Synaptic Plasticity Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Exocytosis Regulation Of Cell Junction Assembly Positive Regulation Of Cell Communication Positive Regulation Of Signaling Calyx Of Held Regulation Of Signal Transduction Regulation Of Synapse Organization Calcium Ion Binding Presynaptic Cytosol Postsynaptic Cytosol Transmembrane Transporter Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Transmission Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Metanephric Connecting Tubule Development Terminal Bouton Calcium Ion Binding Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Presynaptic Endocytosis Protein-containing Complex Identical Protein Binding Protein Sequestering Activity Receptor Metabolic Process Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Synapse Assembly Regulation Of Exocytosis Response To Fibroblast Growth Factor Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Phosphoprotein Binding Cytosol Modulation Of Chemical Synaptic Transmission Long-term Synaptic Potentiation Postsynapse Calcium Ion Binding Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle System Process Regulation Of System Process
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