PDE9A and UBD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PDE9A	UBD
Description		phosphodiesterase 9A	ubiquitin like modifier D
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Sarcolemma Cell Projection Perikaryon Perinuclear Region Of Cytoplasm	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Aggresome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding Proteasome Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP Metabolic Process CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neural Precursor Cell Proliferation	Proteolysis Ubiquitin-dependent Protein Catabolic Process Response To Stress Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Type II Interferon Response To Tumor Necrosis Factor Myeloid Dendritic Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Aggresome Assembly Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		cGMP effects	Neddylation
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Perceived unattractiveness to mosquitoes ( 28199695)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 25429064) Hemoglobin levels ( 32327693) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		43 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERCC1 FXR1 FXR2 GORASP2 HERC2 HIPK1 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SNRNP70 SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5 ZMYM5	29 interacting genes: MAD2L1 NUB1 OTUB1 PDE9A PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMD2 PSMD4 SAE1 SRPK1 SRPK2 TGFBR1 UBA2 UBA6 UBE2D2 UBE2Z USP16
Entrez ID		5152	10537
HPRD ID		09115	09354
Ensembl ID		ENSG00000160191	ENSG00000213886
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	A0A1U9X8S6 O15205
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ 7F0I 8BPY	2MBE 6GF1 6GF2 7PYV 9E8O
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytosol Identical Protein Binding Aggresome Assembly Cytosolic Ciliogenesis Protein Binding Pyrimidine Dimer Repair Positive Regulation Of Long-term Neuronal Synaptic Plasticity Inclusion Body Assembly	Proteasome Core Complex Proteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Proteasome Core Complex, Alpha-subunit Complex Protein Catabolic Process Protein Metabolic Process Proteasome Core Complex, Beta-subunit Complex Nucleoplasm Catabolic Process Macromolecule Metabolic Process Nucleus Cytosol Extracellular Exosome Threonine-type Endopeptidase Activity Ubiquitin-like Modifier Activating Enzyme Activity Secretory Granule Lumen Ficolin-1-rich Granule Lumen SUMO Activating Enzyme Activity SUMO Activating Enzyme Complex Cytoplasm Ubiquitin Activating Enzyme Activity Endopeptidase Activity Small Protein Activating Enzyme Binding Protein Modification Process Post-translational Protein Modification Proteasome Regulatory Particle, Base Subcomplex Positive Regulation Of Protein Sumoylation Proteasome Accessory Complex P-body Regulation Of Protein Sumoylation Regulation Of Post-translational Protein Modification Peptidase Activity Protein Modification By Small Protein Conjugation Protein Binding Positive Regulation Of Viral Genome Replication Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin Conjugating Enzyme Activity Lipopolysaccharide Binding Purine Ribonucleoside Triphosphate Binding Positive Regulation Of Ribosome Biogenesis FAT10 Activating Enzyme Activity Peptidyl-serine Phosphorylation Spliceosomal Complex Assembly Negative Regulation Of Viral Genome Replication
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