PDE9A and NFIL3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PDE9A	NFIL3
Name		phosphodiesterase 9A	nuclear factor, interleukin 3 regulated
Structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Sarcolemma Cell Projection Perikaryon Perinuclear Region Of Cytoplasm	Chromatin Nucleus RNA Polymerase II Transcription Regulator Complex
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP Metabolic Process CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neural Precursor Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Natural Killer Cell Differentiation DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Immune Response Circadian Rhythm Positive Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Cellular Response To Interleukin-4
Pathways		cGMP effects	None
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil	None
GWAS		Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Perceived unattractiveness to mosquitoes ( 28199695 )	Bipolar disorder (inflammation and infection response interaction) ( 25781172 ) Birth weight ( 31043758 ) Inflammatory bowel disease ( 23128233 ) Offspring birth weight ( 31043758 )
Novel Interactors		3 novel interactors: ERG MX1 PCNT	None recorded
Interacting Genes		43 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERCC1 FXR1 FXR2 GORASP2 HERC2 HIPK1 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SNRNP70 SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5 ZMYM5	18 interacting genes: AMOTL2 BATF CFTR CREB3 DDIT3 DELEC1 DNMT3L DR1 FHL1 GMCL1 HSF2BP MAFF MAFG PDE9A PIH1D2 RINT1 TRAF2 UBR5
Entrez ID		5152	4783
HPRD ID		09115	05619
Ensembl ID		ENSG00000160191	ENSG00000165030
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	Q16649
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ 7F0I 8BPY	8K86 8K89 8K8A
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytosol Identical Protein Binding Aggresome Assembly Cytosolic Ciliogenesis Protein Binding Pyrimidine Dimer Repair Positive Regulation Of Long-term Neuronal Synaptic Plasticity Inclusion Body Assembly	RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling CAMP Response Element Binding Protein Binding Response To Endoplasmic Reticulum Stress Cellular Response To Stress DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of RNA Metabolic Process Male Meiosis I Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Ion Transport Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress DNA Damage Response DNA-binding Transcription Factor Activity TORC2 Complex Disassembly Positive Regulation Of Deacetylase Activity Meiosis I Positive Regulation Of Gene Expression Positive Regulation Of Anion Channel Activity Positive Regulation Of Monoatomic Anion Transport Regulation Of DNA-templated Transcription Negative Regulation Of Determination Of Dorsal Identity Negative Regulation Of DNA-templated Transcription Endoplasmic Reticulum Unfolded Protein Response CHOP-C/EBP Complex Negative Regulation Of Transcription By RNA Polymerase II CHOP-ATF4 Complex Intracellular Signal Transduction CHOP-ATF3 Complex Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Diaphragm Contraction Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Vascular Associated Smooth Muscle Cell Migration Negative Cofactor 2 Complex General Transcription Initiation Factor Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Epidermis Development Sequence-specific Double-stranded DNA Binding Regulation Of Epidermal Cell Differentiation TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Meiosis I Cell Cycle Process