ERCC1 and ZCCHC2

Data Source: HiPPIP (Novel)

		ERCC1	ZCCHC2
Name		ERCC excision repair 1, endonuclease non-catalytic subunit	zinc finger CCHC-type containing 2
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm ERCC4-ERCC1 Complex	Cytoplasm
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	Nucleic Acid Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Telomere Maintenance DNA Repair Nucleotide-excision Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Mitotic Recombination Syncytium Formation DNA Damage Response Response To Oxidative Stress Germ Cell Development Spermatogenesis Cell Population Proliferation Determination Of Adult Lifespan Male Gonad Development UV Protection Response To X-ray Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Post-embryonic Hemopoiesis Multicellular Organism Growth Interstrand Cross-link Repair Isotype Switching Insulin-like Growth Factor Receptor Signaling Pathway Cell Development Oogenesis Chromosome Organization Positive Regulation Of Transcription Initiation By RNA Polymerase II Telomeric DNA-containing Double Minutes Formation UV-damage Excision Repair Replicative Senescence T-circle Formation Positive Regulation Of T-circle Formation Negative Regulation Of Protection From Non-homologous End Joining At Telomere	None
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	None
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome	None
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x age interaction ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Simvastatin-induced myopathy ( 31220337 )	A body shape index ( 34021172 ) Asthma (age of onset) ( 31036433 ) Asthma (childhood onset) ( 31036433 ) Bipolar disorder ( 31043756 33263727 ) Breastfeeding duration ( 25475840 ) Chronotype ( 30696823 ) Cognitive function in longevity ( 33607172 ) Menopause (age at onset) ( 29773799 ) Morning person ( 30696823 ) Pulse pressure ( 30224653 ) Serum albumin levels ( 23022100 ) Waist circumference adjusted for body mass index ( 34021172 )
Novel Interactors		1 novel interactors: ZCCHC2	7 novel interactors: ERCC1 HMSD MDM4 PHLPP1 PIGN RELCH SERPINB7
Interacting Genes		19 interacting genes: APP CHRM5 DRC4 ERCC4 KIF11 MKRN3 PDE9A RAD52 RPA1 RPA2 RPA3 SLX1A TRMT2B UBL7 UHRF1 USHBP1 USP45 VPS37B XPA	2 interacting genes: RNF10 SHANK3
Entrez ID		2067	54877
HPRD ID		00533	11696
Ensembl ID		ENSG00000012061	ENSG00000141664
Uniprot IDs		P07992	Q9BRD4 Q9C0B9
PDB IDs		1Z00 2A1I 2A1J 2JNW 2JPD 2MUT 6SXA 6SXB	Not available
GO Terms Enriched among Interactors		Nucleotide-excision Repair Recombinational Repair Double-strand Break Repair Via Homologous Recombination DNA Replication Factor A Complex DNA Repair Double-strand Break Repair DNA Recombination Damaged DNA Binding DNA Metabolic Process Telomere Maintenance DNA Damage Response Base-excision Repair Single-stranded DNA Binding Telomere Organization Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Chromosome Organization Nucleotide-excision Repair Factor 1 Complex Mismatch Repair Cellular Response To Stress Nucleic Acid Metabolic Process DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nucleobase-containing Compound Metabolic Process G-rich Strand Telomeric DNA Binding UV Protection Macromolecule Metabolic Process Organelle Organization Mitotic Recombination Site Of Double-strand Break Response To Stress Positive Regulation Of Long-term Synaptic Potentiation DNA Double-strand Break Processing Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening DNA Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Telomere Maintenance Chromosome, Telomeric Region Double-strand Break Repair Via Single-strand Annealing Nucleotide-excision Repair, DNA Damage Recognition Histone H3 Ubiquitin Ligase Activity RRNA (uridine-C5-)-methyltransferase Activity Mitotic Spindle Assembly Regulation Of CAMP/PKA Signal Transduction DNA Binding Regulation Of Telomere Maintenance Via Telomere Lengthening	None