ANXA4 and SMPD1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		ANXA4	SMPD1
Name		annexin A4	sphingomyelin phosphodiesterase 1
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell Surface Vesicle Membrane Membrane Extracellular Matrix Cytoplasmic Vesicle Nuclear Membrane Zymogen Granule Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Endosome Lipid Droplet Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Identical Protein Binding Calcium-dependent Protein Binding NF-kappaB Binding Transcription Regulator Inhibitor Activity	Sphingomyelin Phosphodiesterase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphatidylcholine Phospholipase C Activity Metal Ion Binding Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction Notch Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Epithelial Cell Differentiation Negative Regulation Of Interleukin-8 Production Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction	Plasma Membrane Repair Lipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Xenobiotic Stimulus Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Cholesterol Efflux Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Wound Healing Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Endocytosis Glycosphingolipid Catabolic Process Ceramide Biosynthetic Process Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Pyroptotic Inflammatory Response Response To Interleukin-1 Cellular Response To Calcium Ion
Pathways		None	Glycosphingolipid catabolism
Drugs		Fluocinolone acetonide Copper	Amlodipine Chlorpromazine Desipramine Medical Cannabis
Diseases		None	Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Atrial fibrillation ( 28416818 30061737 ) Palmitoleic acid (16:1n-7) levels ( 23362303 )	Blood protein levels ( 30072576 ) Diisocyanate-induced asthma ( 25918132 ) Malaria ( 31844061 ) Neurological blood protein biomarker levels ( 31320639 )
Interacting Genes		8 interacting genes: GP2 NMT2 PADI4 POT1 RHOU SMPD1 TINF2 UCHL5	6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		307	6609
HPRD ID		00112	06353
Ensembl ID		ENSG00000196975	ENSG00000166311
Uniprot IDs		P09525 Q6P452	E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		2ZOC	5I81 5I85 5I8R 5JG8
GO Terms Enriched among Interactors		Telomere Assembly Positive Regulation Of Telomere Maintenance Shelterin Complex Nuclear Telomere Cap Complex Telomere Maintenance Positive Regulation Of Chromosome Organization Telomere Capping Regulation Of Telomere Maintenance Regulation Of DNA Strand Elongation Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Component Organization Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Antigen Transcytosis By M Cells In Mucosal-associated Lymphoid Tissue Phosphatidylcholine Phospholipase C Activity Acid Sphingomyelin Phosphodiesterase Activity Histone H3R8 Arginine Deiminase Activity Histone H3R17 Arginine Deiminase Activity Histone H3R2 Arginine Deiminase Activity Chromosome Organization Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Glycylpeptide N-tetradecanoyltransferase Activity N-terminal Peptidyl-glycine N-myristoylation Peptidyl-lysine N6-myristoyltransferase Activity Histone H3R26 Arginine Deiminase Activity Histone Arginine Deiminase Activity Positive Regulation Of Telomeric Loop Disassembly Perinucleolar Chromocenter Regulation Of DNA Metabolic Process Termination Of Signal Transduction 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Positive Regulation Of Organelle Organization Negative Regulation Of DNA Metabolic Process N-terminal Protein Myristoylation Telomeric D-loop Binding Protein-arginine Deiminase Activity Single-stranded Telomeric DNA Binding Regulation Of Cellular Component Organization	Phosphatidylserine Binding Calcium-dependent Protein Binding Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Calcium-dependent Phospholipid Binding Epithelial Cell Differentiation Vesicle Membrane Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Cytokine-mediated Signaling Pathway Fatty Acid Amide Hydrolase Activity Regulation Of Lipid Biosynthetic Process N-acylsphingosine Amidohydrolase Activity Apolipoprotein A-I Receptor Binding Negative Regulation Of Pinocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Type II Interferon-mediated Signaling Pathway Nucleus Chromaffin Granule Membrane Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Cell Differentiation Negative Regulation Of Biosynthetic Process Phospholipase Inhibitor Activity Negative Regulation Of Gene Expression Response To Phorbol 13-acetate 12-myristate Sphingoid Biosynthetic Process Sphingosine Biosynthetic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Digestive System Process Regulation Of Type II Interferon-mediated Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Response To Type II Interferon Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Regulation Of Lipid Metabolic Process Zymogen Granule Membrane Nuclear Retinoid X Receptor Binding Death Receptor Binding Sphingosine Metabolic Process Ceramide Catabolic Process Regulation Of Triglyceride Biosynthetic Process Protein Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of DNA-templated Transcription