DSC3 and PKP3

Number of citations of the paper that reports this interaction (PMID 12707304)
37

Data Source:
HPRD (two hybrid, in vivo)

		DSC3	PKP3
Gene Name		desmocollin 3	plakophilin 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Integral Component Of Membrane Desmosome	Nucleus Plasma Membrane Cell-cell Junction Desmosome
	Molecular Function	Calcium Ion Binding Gamma-catenin Binding	Cell Adhesion Molecule Binding
	Biological Process	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization	Desmosome Assembly Single Organismal Cell-cell Adhesion Establishment Of Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		5 interactors: CTNNB1 JUP PKP3 PKP4 UCHL5	9 interactors: DSC1 DSC2 DSC3 DSG1 DSG2 DSG3 DSP JUP KRT18
Entrez ID		1825	11187
HPRD ID		02604	05711
Ensembl ID		ENSG00000134762	ENSG00000184363
Uniprot IDs		Q14574	F8J390 Q9Y446
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Junction Assembly Cell-cell Junction Organization Desmosome Assembly Cellular Response To Indole-3-methanol Desmosome Organization Cell-cell Junction Assembly Single Organismal Cell-cell Adhesion Regulation Of Cell Fate Specification Regulation Of Cell Fate Commitment Adherens Junction Assembly Cell Adhesion Establishment Of Protein Localization To Plasma Membrane Adherens Junction Organization Cellular Component Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Protein Heterooligomerization Protein Localization To Plasma Membrane Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Wnt Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Cell-cell Adhesion Glial Cell Fate Determination Oviduct Development Regulation Of Centriole-centriole Cohesion Positive Regulation Of Determination Of Dorsal Identity Lung Induction Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Response To Mechanical Stimulus Skin Development Regulation Of Signal Transduction Plasma Membrane Organization Regulation Of Canonical Wnt Signaling Pathway Establishment Of Protein Localization To Membrane Central Nervous System Vasculogenesis Trachea Formation Regulation Of Centromeric Sister Chromatid Cohesion Renal Vesicle Formation Regulation Of Signaling Negative Regulation Of Protein Sumoylation Positive Regulation Of Branching Involved In Lung Morphogenesis	Bundle Of His Cell To Purkinje Myocyte Communication Ventricular Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Action Potential Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Adhesion Regulation Of Muscle Contraction Regulation Of Heart Contraction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Execution Phase Of Apoptosis Regulation Of Membrane Potential Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Regulation Of Actin Filament-based Process Single Organismal Cell-cell Adhesion Regulation Of Cellular Component Movement Desmosome Organization Apoptotic Process Programmed Cell Death Cell Death Death Cell-cell Junction Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Response To Progesterone Golgi To Plasma Membrane CFTR Protein Transport Establishment Of Protein Localization To Plasma Membrane Maternal Process Involved In Female Pregnancy Adherens Junction Organization Protein Stabilization Ventricular Compact Myocardium Morphogenesis Cell-cell Junction Assembly Signaling Cell Communication Endothelial Cell-cell Adhesion Regulation Of Protein Stability Cellular Response To Starvation Response To Stimulus Protein Localization To Plasma Membrane Desmosome Assembly Protein Localization To Adherens Junction Cellular Response To Indole-3-methanol
Tagcloud ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	ankrd33b asthma beadchip cntd2 concordant cpg detrimental dpp10 enrichment epigenome fetal goal gtf2h2c gtf2h2d humanmethylation450 illumina ius lung mapped methylation methylome nicotine origins placental smoke surrogate utero variation wheezing
Tagcloud (Difference) ?		cadherins companion continuity desmocollin desmoglein desmoplakin desmosomal desmosomes displaying dsc1 dsc2 dsg1 dsg2 dsg3 exclusive follicle hair immunopositive mutually ontogenic outer plakoglobin plakophilin practically rood root sheath subinfundibular trichocytes	ankrd33b asthma beadchip cntd2 concordant cpg detrimental dpp10 enrichment epigenome fetal goal gtf2h2c gtf2h2d humanmethylation450 illumina ius lung mapped methylation methylome nicotine origins placental smoke surrogate utero variation wheezing
Tagcloud (Intersection) ?