DSC3

Description		desmocollin 3
Image		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Region Cytoplasm Plasma Membrane Cell-cell Junction Membrane Cell Junction Desmosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Gamma-catenin Binding Metal Ion Binding
	Biological Process	In Utero Embryonic Development Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Protein Stabilization Cell-cell Adhesion
Pathways		Keratinization Formation of the cornified envelope
Drugs
Diseases		Hypotrichosis and recurrent skin vesicles
GWAS		Bronchopulmonary dysplasia ( 23897914) Hand grip strength (Mahalanobis distance) ( 32235003) Metabolite levels ( 31628463) Obesity-related traits ( 23251661) Protein quantitative trait loci ( 18464913) Supraventricular ectopy ( 29618737) Type 2 diabetes ( 31049640)
Novel Interacting Genes		2 novel interacting genes: DDX10 DSC2
Interacting Genes		5 interacting genes: CTNNB1 JUP PKP3 PKP4 UCHL5
Entrez ID		1825
HPRD ID		02604
Ensembl ID		ENSG00000134762
Uniprot IDs		Q14574
PDB IDs
Enriched GO Terms of Interacting Partners?		Desmosome Adherens Junction Cornified Envelope Alpha-catenin Binding Cell-cell Junction Assembly Anchoring Junction Cell-cell Junction Organization Cell-cell Adhesion Catenin-TCF7L2 Complex Intercalated Disc Cell-cell Junction Cell Junction Cellular Response To Indole-3-methanol Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication Cell Junction Assembly Response To Indole-3-methanol Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication Cardiac Muscle Cell-cardiac Muscle Cell Adhesion Desmosome Assembly Cadherin Binding Cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Desmosome Organization Cell Junction Organization Epithelial Cell-cell Adhesion Catenin Complex Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Contraction Midbrain Development Heterotypic Cell-cell Adhesion Regulation Of Heart Rate By Cardiac Conduction Detection Of Mechanical Stimulus Protein-DNA Complex Nuclear Receptor Binding Regulation Of Cell Adhesion Cardiac Conduction Skin Development Regulation Of Action Potential Homotypic Cell-cell Adhesion Positive Regulation Of Telomere Maintenance Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Gamma-catenin-TCF7L2 Complex Regulation Of Cell Cycle Regulation Of Cardiac Muscle Contraction Regulation Of Embryonic Development Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex
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